Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$100K - $120K *

Champion enterprise communications and change initiatives, enhancing employee engagement and understanding. Collaborate across departments to ensure clear, consistent messaging and drive organizationa...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $190K *

Shape innovative IT solutions by leading technical strategies for federal proposals. Collaborate with teams to design enterprise architectures, ensuring alignment with business goals while serving as...

Virginia, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $120K *

Engage in complex contract administration, ensuring compliance and strategic alignment. Collaborate with stakeholders to navigate contractual obligations and develop innovative solutions that support...

Virginia, USRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Transform the Oregon Health Insurance Marketplace by leveraging your expertise in health insurance platforms, ensuring compliance with CMS and IRS standards. Guide the transition with in-depth technic...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$62K - $139K *

Champion data integrity by designing and executing comprehensive test plans for ETL processes and large-scale data platforms, ensuring quality and accuracy across systems while collaborating in an Agi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$174K - $197K *

Champion strategic client relationships and lead virtual teams to drive growth in our Health Life Sciences vertical, ensuring exceptional customer experiences and achieving financial targets through i...

New York, NYRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Join a team that's driving growth in enterprise services by developing strategies and leading engagements with Global Service Providers. Collaborate with top-tier clients to enhance service delivery a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $153K *

Empower engineering teams by driving enterprise-scale Infrastructure as Code (IaC) initiatives. Design and build reusable automation solutions, establish standards, and collaborate across teams to tra...

Arizona, USRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$69K - $105K *

Champion application and cloud security by conducting assessments, integrating security into CI/CD pipelines, and collaborating with development teams to enhance secure coding practices and vulnerabil...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$116K - $207K *

Contribute to the successful delivery of large-scale IT programs, leading high-performing teams, driving operational excellence, and fostering strong client relationships to align with strategic objec...

Dallas, TXRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $190K *

Lead and innovate in cybersecurity by enhancing security delivery through automation and AI. Collaborate across teams to identify gaps, improve compliance, and strengthen processes, ensuring consisten...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$87K - $157K *

Transform healthcare data processing by designing and developing robust backend services. Collaborate with cross-functional teams to integrate AI and machine learning, ensuring reliable, standards-bas...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$120K - $165K *

Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$80K - $100K *

Collaborate with cross-functional teams to implement and configure innovative solutions on a risk and compliance platform, ensuring customer success through expertise and effective communication in a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Innovate data engineering solutions in mission-critical environments, collaborating closely with users and engineers to deploy and operate data capabilities. Tackle complex integrations and enhance da...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$116K - $151K *

Take ownership of the Knowledge & Enablement function, driving strategy and execution to enhance self-service effectiveness and agent performance. Collaborate with cross-functional teams to ensure imp...

CanadaRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining HR technology! Lead the design and management of our Workday system, collaborating across departments to enhance HR and Payroll processes through innovative solutions and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $158K *

Join our team as an SAP EHS Dangerous Goods Specialist, where you'll lead the configuration and support of critical processes, ensuring compliance with global regulations while collaborating across fu...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Champion security excellence by designing and implementing robust security controls across hybrid environments, collaborating with cross-functional teams to enhance overall protection and response cap...

CanadaRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$95K - $115K *

Explore innovative solutions as an Epic Application Analyst Senior, enhancing Radiant workflows and optimizing imaging operations to improve patient care. Collaborate with stakeholders to define techn...

Wisconsin, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Optimize real-time automation solutions across manufacturing and enterprise levels. Collaborate with engineering teams to design, implement, and enhance systems using diverse programming and design to...

Richmond, VARemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Transform your career by engineering innovative automation solutions across industries. Collaborate with a dynamic team to enhance operational efficiency and drive real-time information systems from t...

Raleigh, NCRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$92K - $110K *

Elevate your career by engineering real-time automation solutions across industries. Collaborate with a dynamic team to design, implement, and optimize systems that enhance operational efficiency and...

Philadelphia, PARemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Elevate partner engagement by driving strategic initiatives with System Integrators. Collaborate cross-functionally to enhance delivery capabilities and execute joint go-to-market strategies, ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team as a Senior Costpoint System Administrator, overseeing Deltek Costpoint ERP management, ensuring system security, compliance, and seamless integrations while supporting finance and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.