Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$135K - $171K *

Drive strategic initiatives to enhance renewals performance, boost recurring revenue, and improve customer retention. Collaborate with cross-functional teams to translate business strategies into acti...

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1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$86K - $124K *

Champion the future of project management by leading SAP initiatives, driving agile practices, and delivering innovative solutions that meet client needs while fostering team collaboration and continu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Lead the design and development of robust security architecture for cloud infrastructure and CI/CD pipelines. Partner cross-functionally to embed security in the development lifecycle and evaluate eme...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Media

$85K - $100K *

Join a dedicated team as you empower Oncology patients by providing holistic care, navigating healthcare systems, and ensuring access to life-changing therapies while collaborating with healthcare pro...

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1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by crafting compelling content that guides security teams through their buying journey. Collaborate with experts, leverage AI, and drive engagement through innovative writing and s...

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3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$125K - $150K *

Pioneer the success of large-scale construction projects, ensuring timely delivery and quality standards. Lead diverse teams, manage client relationships, and drive strategic planning while overseeing...

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Today

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $90K *

Join a team that's dedicated to patient safety in the operating room. As an IOM Technologist, you'll monitor critical neurological functions during surgery, collaborating closely with surgeons to ensu...

Ohio, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Drive safety excellence by ensuring compliance with health and safety regulations across construction projects. Collaborate with multidisciplinary teams to implement safety policies, conduct inspectio...

New York, NYRemote

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $135K *

Accelerate demand generation and revenue growth in cybersecurity services by collaborating with sales teams and partners, leading customer engagements, and developing tailored service solutions to dri...

Dallas, TXRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

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3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $145K *

Join a team that's revolutionizing cloud infrastructure by designing tools for automation and efficiency. Contribute to impactful AI systems and play a key role in optimizing costs and ensuring robust...

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Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $186K *

Accelerate data-driven transformations by leading D&A sales cycles, engaging with executives, and driving adoption of innovative AI solutions to enhance customer business outcomes and strategies...

Chicago, ILRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to optimizing Epic systems through installation, configuration, and maintenance, ensuring seamless operation and support for both physical and virtual environments across...

New Hampshire, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$214K - $292K *

Transform late-stage gene therapy programs by leading cross-functional teams, ensuring strategic execution from pivotal trials to commercial launch, while fostering a culture of operational excellence...

San Diego, CARemote

Reposted today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive application reliability by improving codebase performance and support systems integration. Collaborate across teams to ensure robust observability, facilitate incident response, and automate ope...

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Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$127K - $243K *

Lead a high-performing team to define and execute technology strategies for Property & Casualty, driving modernization and operational efficiencies while ensuring agile delivery and stakeholder collab...

Plano, TXRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Join a team that's dedicated to delivering seamless technical solutions for clients. You'll scope, implement, and maintain risk screening and data integration workflows, ensuring optimal performance a...

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Today

  •   Less than 5 years exp.  •   Information Technology

$115K - $130K *

Drive seamless post-merger integrations by coordinating cross-functional teams, unifying processes, and fostering alignment. Lead initiatives that enhance operational efficiency and support future acq...

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4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$91K - $146K *

Join a team that's dedicated to optimizing HR processes through effective management of the Workday HRIS. Collaborate with HR and IT to enhance system functionality, ensure data integrity, and support...

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Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$75K - $158K *

Empower the future of government software as an Oracle EBS UMX Functional Analyst. Collaborate cross-functionally to enhance user management solutions and deliver efficient implementations in a vibran...

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Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$167K - $200K *

Empower strategic innovation in cybersecurity by leading research initiatives, fostering industry collaborations, and guiding decision-making to enhance organizational impact and reputation in the fie...

Santa Clara, CARemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$172K - $202K *

Lead innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients in navigating complex market challenges and achieving their business objectives...

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1 week ago

  •   11 - 15 years exp.  •   Business Services

$92K - $154K *

Unlock potential by leading complex, cross-functional projects in a fast-paced infrastructure environment, driving execution among diverse technical and business teams, while adapting to evolving prio...

Colorado, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $130K *

Deliver innovative security solutions by engineering, implementing, and maintaining Privileged Access Management systems to protect identities and systems. Collaborate across engineering and architect...

Illinois, USRemote

1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join our team to enhance operational systems for our go-to-market efforts. You’ll collaborate with multiple departments to optimize workflows, automate processes, troubleshoot issues, and improve data...

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Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.