Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
Capture & Business Development Manager
$85K - $110K *
Drive business growth by identifying and qualifying federal procurement opportunities, focusing on healthcare contracts. Collaborate on capture strategies and build partnerships to enhance win probabi...
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Senior Professional Services Specialist
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Manager - Cloud Foundation Services
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3 weeks ago
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Lead the design and implementation of Manufacturing Execution Systems (MES) in the biotech and pharmaceutical sectors, ensuring effective integration and documentation while fostering strong client re...
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Director, Global MSP Ecosystem Sales
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Transform the global MSP ecosystem by leading a dynamic Partner Development team, driving revenue growth and enhancing partner relationships across a strategic security product portfolio for SMBs worl...
3 weeks ago
Engineer II, Data Analytics (Remote)
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Empower customer success by leading strategic service delivery for major accounts. Drive adoption of security solutions, collaborate with C-suite leaders, and manage the entire services lifecycle to m...
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Drive the strategic IT vision and execution for a mid-sized organization, leading a team to enhance operational efficiency, manage vendor relationships, and ensure secure, compliant systems that impro...
1 week ago
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Shape client strategies by managing complex engagements, driving team performance, and enhancing customer experiences. Leverage industry expertise to solve challenges and mentor junior staff while ens...
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Drive operational excellence by leading client success, operations, and implementation efforts. Cultivate teams, streamline processes, and ensure high-quality delivery for enterprise clients, all whil...
Reposted today
Advisor II, Health Supply Chain, Continuity of Integrated Health Services (CIHS) Project
$80K - $95K *
Empower global health initiatives by enhancing supply chain systems across multiple countries. Collaborate with teams to ensure compliance, efficiency, and capacity building in logistics and procureme...
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$74K - $124K *
Drive risk management and IT auditing excellence by assessing controls, evaluating risks, and delivering actionable insights. Collaborate effectively across teams to enhance the internal control envir...
Reposted 3 weeks ago
$100K - $120K *
Accelerate progress at our facilities by leading operations and buildouts. Manage day-to-day activities, enhance employee experiences, and develop scalable processes to support a growing organization...
2 days ago
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3 weeks ago
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4 days ago
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Join a team that's shaping the future of program management by leveraging your software systems engineering expertise and product ownership skills to drive innovative solutions in a cloud-native envir...
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Software Systems Engineer Principal
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Join a team that's shaping the future of program management solutions. Leverage your software systems engineering expertise and product ownership skills to drive innovation and deliver high-quality, c...
2 days ago
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Empower higher education institutions by optimizing Ellucian solutions. In this customer-facing role, leverage your expertise to enhance student information systems, streamline processes, and drive op...
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Financial Systems Training Specialist
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Advance your career by designing and delivering engaging eLearning experiences that enhance organizational training and employee performance using cutting-edge development tools and collaboration with...
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Clinical Documentation Integrity Supervisor
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1 week ago
Clinical Documentation Integrity Supervisor
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Lead the charge in enhancing clinical documentation integrity by supervising staff, conducting quality reviews, and fostering professional development. Collaborate with teams to implement effective st...
1 week ago
$98K - $206K *
Unlock the potential of data engineering by automating cloud data ingestion and transformation processes. Utilize cutting-edge AWS services to ensure reliability and performance in a mission-driven en...
Reposted 1 week ago
$160K - $195K *
Empower enterprise clients by managing strategic relationships, driving revenue growth, and aligning solutions with business objectives. Lead cross-functional teams to deliver exceptional outcomes and...
Yesterday
$110K - $145K *
Empower security and compliance within Microsoft cloud environments by engineering and managing robust security controls while fostering a proactive approach to risk assessment and improvement for org...
3 weeks ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.