Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$67K - $108K *

Support outside plant projects by analyzing records, statistics, and reports. Collaborate with engineering and construction teams to ensure timely and budget-compliant project completion while managin...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$89K - $131K *

Transform healthcare delivery by optimizing Epic Willow applications. Collaborate with pharmacy and IT teams to enhance workflows, ensure compliance, and support safe medication management. Drive syst...

Norfolk, VARemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $230K *

Lead a team that operationalizes advanced AI security solutions for enterprises, ensuring integration and compliance across environments. Collaborate with stakeholders to translate requirements into e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $188K *

Advance global cybersecurity initiatives as an operational partner to the CISO. Lead strategic planning, guide execution, and ensure alignment with organizational goals while fostering collaboration a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$150K - $215K *

Innovate by driving real-time communications strategies and partner engagement. Shape impactful narratives during breaking news while building scalable programs that connect communications outcomes to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Oversee the management of Epic Certified Application Analysts, ensuring effective design, build, and support of the Epic system. Lead teams in optimizing workflows and resolving issues while maintaini...

Bozeman, MTRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $110K *

Advance your career by crafting high-level communications for federal oversight entities. Collaborate with a team to ensure clarity and consistency in executive correspondence, while managing tight de...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$180K - $370K *

Unlock potential by leading a dynamic team of technical sales professionals to deliver innovative solutions. Engage with clients to drive results, enhance collaboration, and optimize sales strategies...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$108K - $130K *

Unlock potential by leading vulnerability management to enhance security posture. Collaborate with technical teams to identify and remediate vulnerabilities, ensuring a resilient infrastructure and co...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$90K - $110K *

Transform customer engagement by delivering tailored product demonstrations, guiding technical discussions, and architecting solutions that meet unique educational needs across diverse sectors...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to innovation and excellence, driving projects from concept to completion. Collaborate with cross-functional teams to enhance product development and ensure quality standa...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $164K *

Unlock potential by leading research and analysis to identify system impacts, dependencies, and business needs. Collaborate with stakeholders to enhance processes and deliver clear requirements in a d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $200K *

Unlock potential by driving enterprise agent solutions with Microsoft technologies. Collaborate on agent governance, lifecycle management, and secure operations, while translating designs into product...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$95K - $115K *

Lead the charge in delivering exceptional medical information services to clients. Provide oversight, manage client relationships, and ensure compliance with performance metrics while mentoring staff...

Chicago, ILRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$114K - $152K *

Join a team that's driving growth in federal sales by developing relationships with key clients in the Department of War. Leverage your expertise to manage a sales pipeline, achieve targets, and provi...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$92K - $115K *

Transform client data integration processes by designing, building, and testing seamless connections between systems. Collaborate with teams to ensure optimal performance and security while delivering...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$145K - $175K *

Elevate your career by leading the development of our cutting-edge Cloud Threat Detection Platform. Drive innovative high-throughput microservices, engineer robust APIs, and shape user-facing applicat...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$166K *

Engage with the Canadian Federal Government to sell Identity Security Solutions, fostering relationships, managing virtual teams and exceeding sales targets through collaboration, strategic planning...

Ottawa, ONRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $180K *

Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Champion middleware and web-services platforms, ensuring stability, security, and performance. Collaborate with cross-functional teams to support enterprise applications in complex environments while...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$85K - $115K *

Drive the design and deployment of innovative cloud-based software for large-scale energy efficiency programs, collaborating with cross-functional teams to translate business goals into actionable pro...

Newark, NJRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $190K *

Join a team that's dedicated to providing comprehensive cybersecurity solutions. Collaborate with sales, educate customers, and drive meetings to address security challenges while showcasing innovativ...

New York, NYRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$207K - $310K *

Champion the Solutions Engineering team by driving technical sales strategies, managing performance, and fostering collaboration to meet organizational goals while ensuring customer success and team d...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$96K - $154K *

Champion the implementation of AI solutions using Red Hat OpenShift, driving client success through hands-on deployments and reusable assets. Collaborate with diverse teams to optimize AI models and e...

Texas, USRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $145K *

Join a dynamic team to ensure seamless network connectivity for dock deployments. Collaborate with IT teams, troubleshoot connectivity issues, and enhance customer confidence through effective communi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.