Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$110K - $130K *

Join a team that's dedicated to enhancing medical device workflows and validation. Leverage your expertise to translate reviewer needs into actionable requirements, ensuring valuable insights while mi...

Arlington, VARemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$98K - $167K *

Drive impactful ServiceNow solutions by designing, implementing, and customizing applications. Collaborate with teams, mentor developers, and ensure client satisfaction through technical excellence an...

Reston, VARemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$86K - $138K *

Take ownership of the Windows and VMware server environment, providing operational support and maintenance. Collaborate on projects, ensure system stability, and implement technology changes to meet o...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$261K - $356K *

Join a team that's driving enterprise growth by modernizing networking and security for cloud-native environments. Build executive relationships and engage technical stakeholders to exceed sales targe...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$154K - $161K *

Champion security excellence by optimizing network infrastructure, driving API security, and troubleshooting complex issues. Collaborate globally to enhance security protocols and ensure robust defens...

Houston, TXRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$57K - $117K *

Pioneer innovative training solutions as a UPK Developer, enhancing the Marine Corps ERP logistics system by creating engaging training materials and simulations. Collaborate with a dedicated team to...

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Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$148K - $263K *

Lead the charge in architecting complex OneStream solutions, translating functional requirements into technical designs, and guiding a team to deliver high-performance financial applications for gover...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$69K - $118K *

Transform your sales career by driving growth and building relationships with reseller partners in the Public Sector. Leverage your expertise to develop strategic account plans and deliver innovative...

Chandler, AZRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Contribute to impactful SaaS implementations, guiding clients through setup, data migration, and training while leading complex projects to success across municipal government sectors...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$195K - $225K *

Innovate within a dynamic team to design, develop, and deploy advanced applications for a transformational initiative. Lead technical solutions and mentor engineers while ensuring optimal application...

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Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$66K - $106K *

Champion the integration of marine and anadromous species data by leading the production of federal species range maps, ensuring compliance with established standards and facilitating collaboration wi...

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3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $130K *

Manage the design and implementation of integrated physical security systems, driving innovative solutions in complex environments while fostering collaboration with clients and stakeholders for enhan...

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Reposted 3 days ago

  •   5 - 7 years exp.  •   Technical Services

$133K - $156K *

Unlock potential by leading the design and delivery of enterprise ServiceNow solutions, collaborating with stakeholders to drive innovation and enhance critical business operations through effective g...

San Francisco, CARemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$201K - $352K *

Join a team that's redefining enterprise AI by building scalable, LLM-enabled applications. Collaborate with customers to deliver impactful solutions, codify reusable assets, and shape the future of A...

Santa Clara, CARemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$73K - $132K *

Drive comprehensive environmental compliance audits nationwide, leading projects from planning to reporting. Collaborate with clients to identify deficiencies and deliver actionable recommendations, w...

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1 week ago

  •   Less than 5 years exp.  •   Technical Services

$150K - $180K *

Unlock potential by leading the development of data-driven cybersecurity solutions. Collaborate with experts to tackle complex security challenges, transforming analytical insights into actionable str...

New York, NYRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's defining and driving enterprise data governance for a federal agency. Collaborate with stakeholders to establish data quality frameworks and compliance protocols, ensuring best prac...

Washington, DCRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $160K *

Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$53K - $110K *

Unlock potential by leveraging data analysis to support public health initiatives. Collaborate on quantitative and qualitative evaluations, ensuring data integrity and contributing to impactful progra...

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6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Lead the planning and execution of Public Safety projects, ensuring timely delivery and effective collaboration across teams. Drive process improvements and maintain client relationships to enhance pr...

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Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $120K *

Join us to lead field operations on government and infrastructure projects nationwide. Oversee construction activities, manage subcontractors, ensure safety compliance, and drive quality control for s...

United StatesRemote

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  •   5 - 7 years exp.  •   Real Estate & Construction

$114K - $218K *

Lead the analysis and design of complex business rules, ensuring effective governance and integration across systems. Collaborate with cross-functional teams to enhance process controls and drive auto...

San Antonio, TXRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $200K *

Champion innovation by developing scalable backend solutions and troubleshooting complex issues within our Cyber-Physical Systems platform. Collaborate with global teams to enhance performance and ens...

New York, NYRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...

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3 days ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $167K *

Transform customer experiences by delivering expert security solutions. Collaborate with cross-functional teams to enhance web security for government agencies, ensuring seamless integration and optim...

Ottawa, ONRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.