Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$88K - $108K *

Transform payer billing implementations by managing complex projects, collaborating across teams, and driving process improvements. Leverage strong problem-solving skills to enhance operational effici...

South San Francisco, CARemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Innovate commercial systems to enhance revenue operations, integrating tools like Salesforce and AI for streamlined workflows. Collaborate across teams to ensure data integrity and optimize processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Analyze technical sales opportunities from discovery to close, leveraging AI tools and client data to drive business cases. Collaborate with cross-functional teams to ensure seamless implementation an...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$92K - $154K *

Oversee the coordination of network infrastructure deployment for new Data Center builds, ensuring alignment across teams and tracking milestones from cable start to Production Ready. Drive accountabi...

Colorado, USRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$224K - $308K *

Transform the MSSP partner landscape by driving adoption, building relationships, and integrating cutting-edge solutions. Collaborate with partners to enhance technical offerings and ensure success ac...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $140K *

Join our dynamic team to drive business development across Federal Agencies, leveraging relationships and strategic insights to secure new contracts and enhance growth. Collaborate with diverse teams...

Rockville, MDRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $179K *

Join a dynamic team as you lead efforts in reliability and disaster recovery for critical cloud-based platforms. Utilize your automation skills and collaborate with cross-functional teams to enhance s...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$130K - $215K *

Unlock potential by leading AI architecture solutions that empower clients through innovative design, hands-on implementation, and strategic guidance, ensuring successful adoption of cutting-edge tech...

Virginia, USRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $190K *

Shape the future of our technology landscape by architecting scalable, secure systems that empower a high-growth environment through innovative SaaS and AI strategies. Lead the implementation of best...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Take ownership of designing, building, and maintaining critical IT system integrations, ensuring data flow and operational efficiency while troubleshooting complex issues and optimizing performance in...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $141K *

Champion quality assurance processes and validate software capabilities through manual and automated testing to ensure reliability, security, and compliance for a large-scale agile software developmen...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$140K - $150K *

Lead the charge in nationwide Cybersecurity Disaster Recovery and Contingency Planning initiatives, providing strategic oversight and technical expertise to enhance organizational resilience and ensur...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Staffing

$95K - $115K *

Champion security excellence by leading initiatives to enhance IT solutions, ensuring the confidentiality, availability, and integrity of information assets while driving secure business growth throug...

Pennsylvania, USRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$59K - $106K *

Lead the charge in optimizing CAD workflows and standards, supporting engineering teams to enhance project delivery efficiency through effective management of CAD systems, templates, and technical doc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$175K - $210K *

Drive the vision and strategy for a diverse product portfolio, enhancing market leadership and customer value. Lead cross-functional teams to ensure successful product lifecycle management and alignme...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$132K - $251K *

Shape the future of international defense programs by leading cross-functional teams, managing global projects, and building strong customer relationships to ensure successful outcomes and compliance...

Kentucky, USRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $145K *

Advance your career by managing complex cybersecurity incidents, leading response efforts, and developing comprehensive incident reports. Collaborate with teams to enhance security protocols and condu...

Montreal, QCRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in incident management and response, driving effective remediation strategies and assessments. Collaborate with teams to formulate incident response plans, conduct training exercises...

Atlanta, GARemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's dedicated to enhancing cybersecurity through expert incident management, response, and analysis. Lead global efforts, develop training scenarios, and create comprehensive reports to...

Vancouver, BCRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$109K - $159K *

Lead the charge in administering cutting-edge cloud technologies, focusing on AWS and Linux systems. Collaborate with development teams to enhance CI/CD pipelines while ensuring system security and re...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$160K - $200K *

Join a team that's redefining the Software Development Lifecycle and Developer Experience. Lead global strategies, build innovative offerings, and drive transformation for clients, leveraging expertis...

CanadaRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$161K - $299K *

Drive impactful change by managing 1LMX product solutions across the enterprise. Collaborate with stakeholders to align transformation capabilities with business needs, ensuring successful deployment...

Connecticut, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$77K - $129K *

Lead technology audits and risk assessments to enhance control environments. Drive integrated audits emphasizing IT risk and SOX compliance while collaborating with cross-functional teams to deliver a...

Dallas, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $165K *

Unlock potential by driving supplier performance through hands-on diagnostics, assessments, and corrective actions. This role requires collaboration with international suppliers to enhance manufacturi...

New Hampshire, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$70K - $110K *

Lead the charge in ensuring an exceptional client experience by bridging communication between internal teams and clients, fostering strong relationships, and proactively addressing client needs while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.