Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$110K - $130K *

Engage with sales teams to identify prospects and demonstrate solutions that enhance organizational security. Educate clients on challenges and drive meetings to provide tailored solutions, ensuring e...

St. Louis, MORemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $231K *

Optimize enterprise analytics solutions to provide real-time insights and reporting for federal HR stakeholders, driving strategic decision-making and compliance in a fast-paced modernization initiati...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $172K *

Transform complex data ecosystems by leveraging your Elasticsearch expertise to design, optimize, and lead advanced analytics initiatives. Collaborate with cross-functional teams to enhance mission-cr...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $130K *

Lead the charge in managing a dynamic OS Administrator team, ensuring seamless RHEL and Windows OS patching in a 24/7 environment while leveraging automation tools and collaborating with cross-functio...

Reston, VARemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$154K - $180K *

Unlock your potential as a strategic leader driving customer support excellence. Own high-impact programs, optimize processes, and collaborate with cross-functional teams to enhance customer experienc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Unlock AI-driven engineering transformation by collaborating with clients to enhance SDLC processes. Drive measurable improvements in delivery speed and quality through innovative solutions and hands...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in managing complex client relationships while guiding a team through the full post-sales lifecycle. Drive product design, implementation, and client success in a hands-on, player-coac...

Chicago, ILRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $125K *

Join us to lead audit engagements for governmental and nonprofit clients, mentor emerging auditors, and solve complex accounting challenges while delivering exceptional client service in a fully remot...

Florida, USRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $180K *

Unlock the potential of IT compliance by leading SOX activities, ensuring effective controls, and fostering collaboration across teams to enhance financial reporting integrity and operational excellen...

Bentonville, ARRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$86K - $138K *

Join us to lead the installation and support of next-gen Voice Communication Switch systems. This role demands technical expertise and customer interaction to ensure seamless transitions and operation...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$110K - $130K *

Lead the development and execution of technical training programs, ensuring alignment with enterprise modernization and operational priorities. Collaborate with stakeholders to enhance workforce profi...

Chicago, ILRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$196K - $270K *

Join a team that's driving innovation in the MSSP ecosystem. Lead technical strategy, engage with partners, and shape the future of security solutions across North America while fostering deep relatio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Drive the success of a 24/7 NOC team by mentoring agents, overseeing infrastructure monitoring, and ensuring effective incident management while fostering a collaborative environment focused on contin...

Plano, TXRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $250K *

Lead the charge in our cybersecurity operations, overseeing teams and strategies to enhance effective security monitoring and incident response while ensuring top-notch service delivery across diverse...

Virginia, USRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Join a team that's shaping the future of secure web applications. Leverage your full-stack development skills to build scalable solutions in a collaborative Agile environment, tackling complex challen...

San Antonio, TXRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$46K - $122K *

Lead the charge in implementing health insurance projects by collaborating with teams, analyzing client needs, and ensuring successful onboarding. Foster relationships and provide mentorship to drive...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion operational excellence by managing client accounts, translating performance data into actionable insights, and fostering strong relationships to align expectations with capabilities. Drive co...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $201K *

Join us to lead the charge in cybersecurity as a Network Engineer Expert, ensuring robust enterprise network security solutions. Collaborate with teams to tackle complex challenges and drive innovatio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $150K *

Unlock potential by shaping the future of Azure DevSecOps. Engage in platform engineering, operational support, and compliance management while collaborating across teams to enhance systems and delive...

North Charleston, SCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Elevate your career by leading complex enterprise projects, driving change, and optimizing client relationships. Collaborate across teams to identify opportunities and enhance project management proce...

Pennsylvania, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $190K *

Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$168K - $238K *

Optimize security governance and policy management by leveraging automation and AI. Collaborate with cross-functional teams to ensure compliance with emerging regulations and enhance policy effectiven...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $163K *

Join a team that provides expert technical support for F-16 electrical systems, coordinates repair activities, and delivers innovative solutions to meet customer needs through collaboration and analys...

Three Rivers, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$130K - $150K *

Contribute to the optimization of our NetSuite ERP platform by leveraging your expertise in system integrations and customizations. Collaborate with cross-functional teams to enhance processes and dri...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$161K - $299K *

Transform the future of C4I systems as a Systems Engineering Manager, leading design initiatives and managing a team to ensure alignment with customer requirements. Drive modernization efforts through...

Colorado, USRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.