Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$110K - $130K *

Shape the future of client IT strategies by providing expert consultation, enhancing technology solutions, and fostering strong stakeholder relationships to drive operational efficiency and business g...

Ontario, CARemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $138K *

Lead client provisioning operations in Revenue Cycle Management, ensuring secure and efficient access throughout the user lifecycle. Collaborate with cross-functional teams to enhance service delivery...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Advance public safety software solutions by driving the product vision and roadmap for Records Management Software, optimizing features and ensuring alignment with customer needs, market trends, and t...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$191K - $293K *

Explore the future of security by leading vulnerability research efforts, enhancing software defenses, and streamlining remediation processes to protect critical networks from emerging threats...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Unlock your potential by developing innovative control systems for diverse industries. Collaborate with clients to solve complex manufacturing challenges through automation and controls, ensuring effi...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$73K - $102K *

Architect and deliver LLM-powered applications, overseeing the entire development lifecycle from design to deployment. Collaborate with cross-functional teams to integrate AI systems and ensure high-q...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$67K - $111K *

Join us to drive software solutions by collaborating on design, coding, and testing. Contribute to quality assurance and user training while enhancing system reliability through proactive problem-solv...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$60K - $152K *

Engage with clients to deliver exceptional software support for MQ on mainframe systems. Collaborate across teams to ensure timely installations, upgrades, and migrations while adhering to best practi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive analytics innovation by transforming data into actionable insights using Microsoft technologies. Collaborate with cross-functional teams to modernize cloud solutions and optimize reporting throu...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Transform financial operations by supporting ERP implementation, analyzing business processes, and ensuring seamless integration across multiple workstreams. Collaborate with teams to enhance system f...

Washington, DCRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Transform healthcare integration by leading onboarding for facilities and vendors into a major enterprise environment, ensuring secure connectivity and seamless data exchange throughout the modernizat...

Tampa, FLRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$99K - $164K *

Drive impactful data-driven projects by leading a diverse team in fraud detection and prevention. Manage contract delivery, timelines, and client relationships while ensuring effective communication a...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Analyze and enhance corporate technology infrastructure, ensuring optimal performance and security. Collaborate with cross-functional teams to troubleshoot complex issues and improve employee experien...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$159K - $257K *

Transform security posture by leading enterprise vulnerability management, prioritizing risks, and driving remediation efforts across diverse technology environments. Collaborate with teams to enhance...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Shape the future of enterprise solutions by bridging technical expertise and strategic vision. Collaborate with cross-functional teams to design impactful architectures that drive customer success and...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $200K *

Champion large-scale enterprise application initiatives, leading Agile teams to drive digital transformation, manage program execution, and ensure alignment with strategic objectives while fostering c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in managing complex IT projects for Federal Government, driving performance and organizational change. Leverage your experience in training and communications to support multiple proje...

Washington, DCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in managing a dynamic team of finance and business ops professionals, ensuring efficient program and travel management, financial operations, and superior executive support for the Dep...

Washington, DCRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Engage with sales teams to identify prospects and demonstrate solutions that enhance organizational security. Educate clients on challenges and drive meetings to provide tailored solutions, ensuring e...

St. Louis, MORemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $231K *

Optimize enterprise analytics solutions to provide real-time insights and reporting for federal HR stakeholders, driving strategic decision-making and compliance in a fast-paced modernization initiati...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$82K - $172K *

Transform complex data ecosystems by leveraging your Elasticsearch expertise to design, optimize, and lead advanced analytics initiatives. Collaborate with cross-functional teams to enhance mission-cr...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $130K *

Lead the charge in managing a dynamic OS Administrator team, ensuring seamless RHEL and Windows OS patching in a 24/7 environment while leveraging automation tools and collaborating with cross-functio...

Reston, VARemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$154K - $180K *

Unlock your potential as a strategic leader driving customer support excellence. Own high-impact programs, optimize processes, and collaborate with cross-functional teams to enhance customer experienc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Unlock AI-driven engineering transformation by collaborating with clients to enhance SDLC processes. Drive measurable improvements in delivery speed and quality through innovative solutions and hands...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in managing complex client relationships while guiding a team through the full post-sales lifecycle. Drive product design, implementation, and client success in a hands-on, player-coac...

Chicago, ILRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.