Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
$144K - $170K *
Lead the charge in delivering complex federal programs for the U.S. Air Force and Space Force. Drive mission-critical IT, cybersecurity, and telecommunications initiatives while ensuring stakeholder s...
1 week ago
$120K - $150K *
Join us to enhance backend systems for critical missions, leveraging your expertise in software development, cloud environments, and API integration to drive innovation and efficiency in our projects...
Yesterday
$80K - $95K *
Drive operational excellence by supporting managed services infrastructure, ensuring seamless incident response, systems administration, and network troubleshooting while collaborating with internal t...
2 days ago
$90K - $110K *
Manage day-to-day infrastructure and customer support, ensuring optimal server performance, security, and incident response. Collaborate on initiatives to enhance operational security and maintain doc...
2 weeks ago
Business System Analyst - Pharmaceutical
$80K - $95K *
Collaborate with sales and IT teams to transform operational data into actionable insights, ensuring effective system configuration and user adoption across Salesforce, CRM, and laboratory platforms t...
Yesterday
Business System Analyst - Pharmaceutical
$80K - $95K *
Transform sales operations by connecting teams and systems. Leverage data from Salesforce, LIMS, and CRM to create impactful reports and dashboards, driving performance improvements and supporting end...
2 days ago
$130K - $135K *
Drive project success by managing all phases from initiation to completion, ensuring timely delivery and budget adherence. Lead cross-functional teams, maintain client communication, and uphold qualit...
2 weeks ago
Sr. Principal Medical Writer - Regulatory Submission Docs (ISE/ISS/Clinical Overview - Must Have)
$114K - $210K *
Join a team that's dedicated to developing high-quality regulatory documents for global submissions. Lead cross-functional projects, mentor junior writers, and ensure compliance with industry standard...
1 week ago
Senior ServiceNow Developer (ITSM SME)
$170K - $175K *
Accelerate progress at the forefront of ITSM modernization, leading the technical implementation of ServiceNow capabilities while collaborating with diverse teams to enhance service management across...
4 weeks ago
$85K - $95K *
Engage with cross-functional teams to create and refine technical documentation for VA Health Technology Management, ensuring clarity and quality for senior leadership and stakeholders...
3 weeks ago
$110K - $130K *
Lead FedRAMP compliance initiatives, coordinating cross-functional teams to ensure project success. Manage execution of strategies, schedules, budgets, and stakeholder engagements while driving accoun...
Reposted 2 weeks ago
Information Assurance Engineer - Intern Conversion
$90K - $92K *
Help us enhance security protocols by developing essential documentation and supporting assessments. Collaborate with a dedicated cyber security team to ensure compliance and effective implementation...
3 days ago
$151K - $241K *
Develop and optimize AI solutions for enhanced member experiences, integrating cutting-edge technologies and engineering practices. Collaborate with cross-functional teams to ensure reliable, scalable...
1 week ago
Junior SAP Integration Developer
$63K - $105K *
Unlock your potential by contributing to SAP Integration Development, where you'll design, test, and support software solutions in a collaborative remote environment, ensuring seamless system communic...
Reposted 2 weeks ago
Cybersecurity Senior Incident Response Analyst - Remote based in the US
$103K - $140K *
Engage in advanced cybersecurity incident response, leading investigations and recovery efforts. Collaborate with cross-functional teams to enhance security posture and document findings, ensuring org...
2 weeks ago
Data Quality and Governance Training Analyst
$94K - $157K *
Champion data quality and governance by developing training programs that empower stakeholders. Collaborate across departments to create impactful materials, conduct demos, and facilitate organization...
3 weeks ago
Strategic Solution Sales Executive, Public Sector - Cybersecurity
$140K - $185K *
Champion strategic growth by driving solution sales within key enterprise accounts. Collaborate with cross-functional teams to identify opportunities, articulate value, and influence client transforma...
6 days ago
$110K - $130K *
Join us to design and oversee the quality assurance framework for our AI platform. You'll implement automated testing, ensure compliance, and collaborate with cross-functional teams to maintain high-q...
2 weeks ago
Cloud Software Engineer - SOCEUR
$114K - $252K *
Engineer scalable cloud-native software solutions for mission-critical operations. Collaborate with cross-functional teams to design, implement, and maintain secure tools on Google Cloud Platform, enh...
Yesterday
Human-Centered Design Specialist IV - Research & Healthcare
$93K - $120K *
Develop actionable insights and narratives from complex healthcare programs, leading HCD research and stakeholder engagement to enhance the Veteran services experience through expert interviews and cl...
1 month ago
Identity and Access Management Engineer - 991307 **Hybrid work in the State of Florida**
$90K - $110K *
Drive the design and operation of robust identity and access management systems, ensuring secure, compliant access across diverse environments while supporting pivotal cybersecurity and operational go...
4 weeks ago
Business Office Integration Tower Director
$150K - $225K *
Grow your career with a pivotal leadership role overseeing IT service delivery, project management, and customer engagement. Drive collaboration across teams to enhance infrastructure operations and e...
1 week ago
Automation & AIOps Lead (TX DIR)
$104K - $166K *
Join a team that's redefining automation and AIOps for state infrastructure. Lead initiatives in AI-enabled operations and drive the evolution of enterprise automation while supporting the Texas Priva...
3 weeks ago
Configuration Management Specialist
$85K - $90K *
Elevate the future of U.S. Coast Guard acquisitions by managing configuration processes for the Waterways Commerce Cutter. Collaborate with teams to ensure compliance and accuracy in documentation and...
Today
$80K - $95K *
Transform your career by managing critical systems operations, enhancing infrastructure, and driving automation in a dynamic environment. Collaborate with a skilled team to ensure high availability an...
2 weeks ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.