Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
$114K - $252K *
Elevate national security through innovative cloud automation in a dynamic role. Architect and automate the infrastructure for AI and data analytics platforms to enhance oversight and efficiency withi...
4 weeks ago
$90K - $160K *
Join a team that's dedicated to protecting information systems from threats and ensuring compliance. In this mid-level role, you'll manage security tools, monitor incidents, and collaborate across dep...
4 weeks ago
$110K - $130K *
Join a team that's dedicated to enhancing cybersecurity through proactive threat detection and response. Collaborate with cross-functional teams to develop and refine intelligence processes, ensuring...
2 days ago
IB Temporary - Medical Information Specialist
$160K - $176K *
Elevate medical information operations by managing inquiries, developing responses, and ensuring compliance. Collaborate with healthcare professionals to deliver high-quality communication and support...
1 week ago
Forward Deployed Engineer (SPECTR) - Clearance Required
$110K - $130K *
Join a team that's transforming mission-critical operations by deploying and integrating advanced asset visibility solutions. Collaborate with DoD users to deliver tailored technical solutions that en...
3 weeks ago
$100K - $140K *
Transform your career by leading cyber risk management initiatives, ensuring compliance, and enhancing security posture for critical data center and cloud services. Collaborate with teams to implement...
2 days ago
$84K - $113K *
Transform your career by managing and optimizing diverse database systems, ensuring high availability and performance for mission-critical applications. Collaborate with a dynamic team to tackle compl...
2 weeks ago
IT Security Analyst - Journey (Lacey)
$85K - $115K *
Unlock your potential as a key player in cybersecurity operations, focusing on vulnerability management and incident response. Collaborate with IT teams to enhance security posture and ensure complian...
1 week ago
Sr. Program Analyst - Transformation
$125K - $160K *
Lead the charge in driving operational excellence and transformation by translating business needs into actionable requirements, managing delivery workflows, and enhancing the Revenue Intelligence por...
Reposted 2 weeks ago
Messaging Specialist-Intermediate
$100K - $115K *
Contribute to the operational support of enterprise messaging systems, ensuring effective email administration, user issue resolution, and mobile device management while enhancing project-based messag...
Today
$110K - $130K *
Join a dynamic team as a Cybersecurity Consultant to evaluate and enhance clients' security postures across diverse environments. Drive proactive assessments, collaborate with experts, and deliver act...
Reposted 2 weeks ago
$95K - $115K *
Lead the technical health of a claims platform by enhancing applications, ensuring system stability, and bridging engineering with business needs. This hybrid role combines hands-on development with s...
Today
Sr. ServiceNow Business Analyst
$92K - $153K *
Transform client experiences by leading ServiceNow implementations, translating business needs into technical solutions, and collaborating with teams to optimize application performance and drive inno...
4 weeks ago
$80K - $95K *
Join a team that's dedicated to advanced support for industrial control systems. As a key escalation point, you'll tackle complex issues, drive system stability, and mentor junior staff in a dynamic 2...
Yesterday
$144K - $170K *
Lead the charge in delivering complex federal programs for the U.S. Air Force and Space Force. Drive mission-critical IT, cybersecurity, and telecommunications initiatives while ensuring stakeholder s...
1 week ago
$120K - $150K *
Join us to enhance backend systems for critical missions, leveraging your expertise in software development, cloud environments, and API integration to drive innovation and efficiency in our projects...
Today
$80K - $95K *
Drive operational excellence by supporting managed services infrastructure, ensuring seamless incident response, systems administration, and network troubleshooting while collaborating with internal t...
Yesterday
$90K - $110K *
Manage day-to-day infrastructure and customer support, ensuring optimal server performance, security, and incident response. Collaborate on initiatives to enhance operational security and maintain doc...
2 weeks ago
Business System Analyst - Pharmaceutical
$80K - $95K *
Collaborate with sales and IT teams to transform operational data into actionable insights, ensuring effective system configuration and user adoption across Salesforce, CRM, and laboratory platforms t...
Today
Business System Analyst - Pharmaceutical
$80K - $95K *
Transform sales operations by connecting teams and systems. Leverage data from Salesforce, LIMS, and CRM to create impactful reports and dashboards, driving performance improvements and supporting end...
Yesterday
$130K - $135K *
Drive project success by managing all phases from initiation to completion, ensuring timely delivery and budget adherence. Lead cross-functional teams, maintain client communication, and uphold qualit...
2 weeks ago
Sr. Principal Medical Writer - Regulatory Submission Docs (ISE/ISS/Clinical Overview - Must Have)
$114K - $210K *
Join a team that's dedicated to developing high-quality regulatory documents for global submissions. Lead cross-functional projects, mentor junior writers, and ensure compliance with industry standard...
1 week ago
Senior ServiceNow Developer (ITSM SME)
$170K - $175K *
Accelerate progress at the forefront of ITSM modernization, leading the technical implementation of ServiceNow capabilities while collaborating with diverse teams to enhance service management across...
4 weeks ago
$85K - $95K *
Engage with cross-functional teams to create and refine technical documentation for VA Health Technology Management, ensuring clarity and quality for senior leadership and stakeholders...
3 weeks ago
$110K - $130K *
Lead FedRAMP compliance initiatives, coordinating cross-functional teams to ensure project success. Manage execution of strategies, schedules, budgets, and stakeholder engagements while driving accoun...
Reposted 2 weeks ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.