Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$185K - $235K *

Join a team that's redefining access in healthcare by leading reimbursement strategies and supporting families in navigating complex pathways for Skeletal Dysplasia therapies. Drive impactful change t...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $172K *

Transform healthcare delivery by managing CDI operations, liaising with vendors, ensuring quality, and fostering staff development. Join a collaborative team to enhance patient care through innovative...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$83K - $113K *

Drive regional clinical study delivery by supporting management and execution of trials, ensuring quality standards and timelines are met. Collaborate with stakeholders and contribute to operational e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Unlock health equity and quality improvement by leading strategic initiatives that enhance outcomes and reduce disparities across diverse populations in value-based care settings. Collaborate with sta...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$106K - $167K *

Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Join a team that's dedicated to transforming patient care through a Whole Health System, managing inpatient medical cases, and collaborating with healthcare professionals to enhance the well-being of...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a team that's dedicated to delivering exceptional patient care while supervising pharmacy staff and championing operational excellence in a compliant environment. Contribute to cultural initiativ...

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$69K - $101K *

Grow your career with a dynamic team providing holistic clinical care management services. Collaborate with diverse populations to enhance health outcomes through assessment, care planning, and coordi...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$54K - $155K *

Join a team that's transforming mental health delivery through innovative, tech-enabled solutions. Provide 24/7 support via video, chat, or phone, ensuring timely access to high-quality mental health...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Partner with us to deliver compassionate, whole-person care for patients with substance use disorders through our innovative telehealth platform, ensuring effective treatment and support in a fully re...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$254K - $382K *

Transform clinical research by leading strategic medical initiatives, ensuring operational excellence, and fostering collaboration across teams. Drive innovation and mentor future leaders while delive...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Staffing

$100K - $140K *

Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Lead the delivery of comprehensive medical care by assessing, diagnosing, and treating patients. Collaborate with healthcare teams to enhance patient education and ensure quality care while adhering t...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Take ownership of after-hours telephonic care for aging residents, providing critical support and clinical direction across multiple states. Deliver high-quality, compassionate care while managing hig...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Elevate patient care by preparing individuals for surgery through thorough assessments, education, and collaboration with surgical teams, ensuring a seamless and compassionate preoperative experience...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K *

Partner with us to enhance product knowledge through comprehensive training programs, ensuring effective customer support and the growth of clinical expertise in the field sales organization. Be a cli...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $190K *

Champion a national team of Medical Science Liaisons focused on obesity, driving strategy and KOL engagement. Lead cross-functional collaboration and ensure compliance while developing high-performing...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.