Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$95K - $110K *

Partner with us to transform healthcare delivery by providing telephonic clinical triage and support. You'll advocate for members, ensuring they receive timely care while collaborating with a dedicate...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$85K - $110K *

Unlock better healthcare experiences by providing telephonic triage and support. As a key advocate for members, you'll connect them with essential resources, ensuring timely and appropriate care while...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform inpatient coding operations by leading a dedicated team to ensure accurate coding, compliance, and timely billing. Collaborate with clinical and administrative staff to enhance financial per...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$174K - $374K *

Strategize clinical oversight and drive innovative medical management programs. Collaborate with a multidisciplinary team to enhance member care outcomes while representing the organization to externa...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$254K - $382K *

Pioneer innovative clinical strategies as a senior medical leader, driving excellence in study execution and client engagement. Collaborate with cross-functional teams to enhance patient care and oper...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$201K - $251K *

Champion Quality governance by leading the development and management of Quality Agreements across global operations, ensuring compliance and effective partnerships with internal and external stakehol...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$54K - $155K *

Lead the charge in telephonic case management, collaborating with patients and care teams to support quality healthcare delivery. Use clinical expertise to assess needs, implement strategies, and ensu...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $120K *

Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...

RemoteRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$105K - $130K *

Elevate patient care by managing clinical support for monitoring systems. Lead diverse teams to enhance customer relationships and ensure effective product utilization post-implementation, driving cli...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$78K - $103K *

Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Elevate clinical research by monitoring trials, ensuring compliance with protocols and regulations. Collaborate with investigators to achieve study goals in dermatology and rheumatology, while working...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K *

Elevate your career by providing clinical support and training for patient monitoring systems. Lead implementation teams, ensure customer satisfaction, and maintain clinical expertise while managing t...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Shape the future of healthcare integration by leading and executing complex HL7 projects. Utilize your expertise in medical informatics and enhancing customer satisfaction while managing dynamic, mult...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive clinical operations excellence by managing protocol compliance, delivering budget oversight, and ensuring successful study start-up in alignment with regulatory standards and internal policies w...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive your career with a leadership role focused on Revenue Integrity, overseeing strategic direction, performance metrics, and team development to enhance operational efficiency and client satisfacti...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Take ownership of medication therapy management services, conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient ca...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$225K - $250K *

Take ownership of strategic access and reimbursement initiatives, leading a team to navigate complex payer environments. Collaborate cross-functionally to enhance provider education and ensure complia...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $290K *

Contribute to the advancement of cancer therapies by managing analytical development and quality control operations, ensuring compliance with regulatory standards, and collaborating across teams to en...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$185K - $235K *

Optimize family access and reimbursement strategies in a hybrid role, collaborating with healthcare providers and families. Leverage your expertise to navigate complex pathways, ensuring compliance an...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.