Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Nurse Educator - Maternal Health
$71K - $107K *
Elevate healthcare education by designing and implementing training programs that enhance maternal and infant health outcomes. Collaborate with clinical and community partners to translate evidence-ba...
Yesterday
RN - Oncology Clinical Research Coordinator
$64K - $96K *
Join a dynamic team to coordinate clinical research studies, ensuring compliance and quality patient care throughout all phases of cancer treatment. Collaborate with diverse stakeholders to enhance tr...
Yesterday
Registered Nurse (RN - III)|Flandreau Med Surg Unit
$67K - $100K *
Join a dedicated team to deliver compassionate nursing care, develop patient care plans, and support families. Collaborate with healthcare professionals to ensure optimal patient outcomes in a dynamic...
Yesterday
Nurse Practitioner or Physician Assistant | Hematology and Transplant | Inpatient
$90K - $110K *
Transform patient care by guiding Oncology patients through complex treatment plans, ensuring a smooth experience and providing essential medical services. Collaborate with healthcare teams to deliver...
Yesterday
Registered Nurse (RN) | Infection Prevention & Control
$64K - $96K *
Lead the Infection Prevention program, ensuring compliance with standards and regulations. Collaborate with healthcare teams to implement policies, analyze data, and enhance patient safety through eff...
Yesterday
Interventional Radiology Technologist
$73K - $111K *
Empower patient care by performing specialized interventional radiology procedures. Collaborate with medical teams to ensure optimal outcomes while maintaining high standards of safety and quality in...
Yesterday
$250K - $300K *
Join a dedicated team to assess, diagnose, and treat patients, ensuring quality care and health education. Collaborate with healthcare professionals to enhance patient outcomes and maintain accurate m...
Yesterday
Registered Nurse (RN) | Med Surg | December 2026 and May 2027 New Grad
$67K - $100K *
Drive exceptional patient care by developing nursing diagnoses, coordinating care plans, and providing holistic support to patients and families. Collaborate with healthcare teams to ensure optimal he...
Yesterday
Registered Nurse (RN) - New Grad - August 2027
$67K - $100K *
Grow your career with a dynamic nursing role focused on patient care, collaboration, and support. Engage in a multidisciplinary team to deliver compassionate healthcare while developing your skills ac...
Yesterday
Auditing & Education Consultant - IP facility or IP/OP
$80K - $95K *
Partner with us to evaluate coding accuracy and compliance in healthcare settings. Utilize your expertise in ICD-10, CPT, and HCPCS coding to conduct audits, deliver educational content, and support c...
Yesterday
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
RN - Surgery Supervisor: OBGYN Service Line
$87K - $131K *
Join a team that's dedicated to delivering exceptional patient care while overseeing nursing staff and collaborating with healthcare professionals to enhance service quality and operational efficiency...
Yesterday
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
Yesterday
Southwest Team Bright Start Home Visiting Program (NIII)
$76K - $89K *
Lead the charge in enhancing community health through effective nurse home visiting. Oversee a dedicated team, ensuring quality implementation of evidence-based practices while fostering strong partne...
Yesterday
Research Data Analysis Supervisor 2 - Remote - 141980
$111K - $211K *
Advance your career by leading impactful research in public health and family planning. Drive data analysis and quality assurance efforts across low- and middle-income countries, collaborating with di...
Yesterday
Executive Director, HEOR Modeling
$175K - $210K *
Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...
Yesterday
Staff Physician, 24/7 Care (Full-Time / 100% Remote)
$143K *
Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...
Yesterday
Case Review Manager - Independent Reviews (IRO/UR)
$85K - $95K *
Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...
Yesterday
FSP Sr. Clinical Research Associate II - Northeast - Ophthalmology
$125K - $142K *
Unlock potential by leading clinical trial monitoring efforts, ensuring compliance and data integrity while collaborating with study teams. Your expertise will enhance patient safety and contribute to...
Yesterday
Senior EHR Data Integration Consultant - Remote, US
$123K - $169K *
Elevate healthcare data integration by leading client engagements, optimizing EHR extracts, and providing strategic guidance. Utilize your SQL expertise to ensure data accuracy and foster strong clien...
Yesterday
Clinical Expert Advisor - Remote, US
$162K - $224K *
Transform healthcare operations by leveraging your expertise to drive efficiency and improve outcomes. Engage with clients to analyze needs, manage projects, and lead teams in delivering sustainable p...
Yesterday
Care Manager, Telephonic Nurse
$71K - $97K *
Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...
Yesterday
Director - Performance Transformation
$206K - $343K *
Lead the charge in transforming healthcare operations by delivering innovative performance solutions. Drive profitable growth through strategic program management and client engagement, ensuring measu...
Yesterday
Managing Consultant - Clinical and Operational Improvement
$102K - $170K *
Elevate your career by driving operational improvements in healthcare. Collaborate with clients to enhance performance through data analysis and strategic workflow redesign, ensuring impactful outcome...
Yesterday
$113K - $188K *
Empower healthcare systems by leading advisory projects, managing teams, and delivering data-driven solutions. Collaborate with clients to enhance performance and build strong relationships while ensu...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.