Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Associate Director, Medical Strategic Operations (Field)
$175K - $219K *
Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...
Today
$80K - $95K *
Deliver comprehensive psychological assessments and evidence-based interventions, guiding treatment plans for complex cases. Collaborate with interdisciplinary teams and supervise trainees while enhan...
Today
Associate Director, Medical Strategic Operations (Sponsorships)
$175K - $219K *
Optimize medical sponsorship strategies and operations by collaborating with stakeholders, managing budgets, and ensuring timely execution of congress activities while enhancing process efficiency and...
Today
Global Value and Access Senior Manager - Rare Disease
$120K - $150K *
Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...
Today
Senior Clinical Research Associate - Early Development - Central/NE Region - FSP
$95K - $115K *
Join a team that's dedicated to ensuring compliance and excellence in clinical trials. Collaborate with cross-functional teams and site personnel to manage monitoring activities, uphold regulatory sta...
Today
Licensed Practical Nurse (LPN)
$83K - $87K *
Unlock your potential as a Licensed Practical Nurse, providing essential care in diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact on patients' lives acr...
Today
Medical Science Liaison, CNS - AR, LA, OK
$150K - $224K *
Advance patient outcomes by leveraging your expertise in CNS as a Medical Science Liaison. Collaborate with healthcare providers and stakeholders to deliver evidence-based insights and drive strategic...
Today
$130K - $150K *
Help us transform care delivery by advising providers on outcomes-based models, implementing frameworks, and leveraging data insights to enhance clinical practices and payer relationships in a collabo...
Today
$125K - $150K *
Unlock potential by leading Health and VA claims operations, driving strategic initiatives, enhancing recovery outcomes, and ensuring operational excellence across multiple teams and client portfolios...
Today
$100K - $120K *
Join us to empower community coalitions in preventing youth substance use. As a Project Officer, you'll manage grants, provide technical assistance, and enhance local capacities, all while collaborati...
Today
$101K - $126K *
Drive the development and execution of clinical programs, ensuring effective support, education, and coordination across departments while managing health outcomes and utilization data for continuous...
Reposted today
Client Engagement Manager - Post-Pay, Specialist
$125K - $187K *
Elevate client engagement by leading post-payment integrity implementations, ensuring seamless communication and alignment across teams. Drive successful outcomes through expert knowledge and strategi...
Yesterday
$70K - $99K *
Empower patient care by utilizing the nursing process to deliver individualized support. Collaborate with a dedicated team in a fast-paced environment, ensuring excellence in all phases of care from a...
Reposted yesterday
Clinical Care Manager -RN - Cambridge, MA
$90K - $120K *
Lead the charge in providing comprehensive care management for dually-eligible enrollees, integrating health services and community resources to enhance health outcomes and quality of life through eff...
Yesterday
$198K - $297K *
Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...
Yesterday
Hazard Communication Analyst (Solventum)
$85K - $117K *
Empower healthcare innovation by authoring and maintaining critical hazard communication documents. Collaborate with diverse teams to ensure compliance and support global regulatory needs, enhancing s...
Yesterday
Licensed Practical Nurse (LPN)
$83K - $87K *
Innovate patient care by providing essential nursing support in diverse settings. Engage with a dynamic team to enhance the quality of life for residents while enjoying flexible scheduling and competi...
Yesterday
$135K - $160K *
Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...
Yesterday
Director, Global Medical Affairs, Omnichannel Transformation & Customer Experience
$192K - $252K *
Lead the transformation of omnichannel engagement in Global Medical Affairs to enhance scientific communications. Collaborate across teams to create customer-centered experiences using insights and em...
Reposted yesterday
Director - Population Health & Well Being
$150K - $160K *
Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...
Yesterday
$85K - $100K *
Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...
Yesterday
Behavioral Health Medical Director
$223K - $313K *
Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...
Reposted yesterday
$74K - $145K *
Lead the Claims operations team, ensuring timely processing and quality outcomes. Oversee staff performance, workflow management, and process improvements while collaborating with executive leadership...
Yesterday
Senior Director, Global Study Management
$236K - $354K *
Elevate clinical operations by leading global study management, driving strategic vision, and ensuring high-quality trial execution. Collaborate across teams to optimize resources and foster a culture...
Yesterday
Mental Health Therapist - Full-Time Telehealth
$70K - $92K *
Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.