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Explore $100K+ Jobs in South Dakota
Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota career opportunities
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Where to find jobs
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Find the right role on Ladders
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Healthcare Jobs in South Dakota
Average Salary: $119,100
Associate Vice President - Early Development Clinical Research Physician - Neuroscience
$268K - $466K *
Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...
1 month ago
Associate Medical Director, Clinical Research
$225K - $281K *
Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...
1 month ago
$210K - $225K *
Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...
1 month ago
Integrated Solution Strategy Director - Oncology
$135K - $160K *
Join us to lead Oncology integrated solutions, collaborating across teams to design and implement strategic, client-focused approaches. Shape impactful proposals that drive growth and enhance patient...
1 month ago
$110K - $182K *
Transform laboratory services by providing expert clinical consultation, enhancing service delivery, and fostering collaboration with healthcare professionals to meet strategic healthcare goals...
1 month ago
Associate Medical Director, Clinical Research
$225K - $281K *
Explore your career in clinical development as you design and lead innovative oncology studies, ensuring data integrity and compliance while collaborating with cross-functional teams and cultivating r...
1 month ago
$250K - $300K *
Champion innovative radiology practices to enhance patient care and operational efficiency alongside a dynamic team. Drive clinical excellence and leverage technology to elevate standards across healt...
1 month ago
$69K - $104K *
Unlock your potential as a coding auditor, ensuring accurate documentation and coding while promoting compliance and reimbursement optimization. Collaborate with coders and specialists to enhance proc...
1 month ago
$85K - $100K *
Drive comprehensive audits, mentor junior staff, and ensure compliance with clinical and financial standards. Enhance revenue cycle performance by identifying issues and recommending improvements, whi...
1 month ago
Managing Consultant - Coding and Middle Revenue Cycle - Healthcare
$120K - $165K *
Lead transformative consulting engagements to enhance healthcare coding and middle revenue cycle processes, driving operational efficiency, compliance, and financial performance across diverse project...
1 month ago
Frequently Asked Questions (FAQ)
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.