Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$210K - $250K *

Deliver comprehensive case reviews and clinical guidance, ensuring regulatory compliance and optimal patient outcomes. Collaborate with healthcare teams across multiple states to enhance service quali...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join us to independently manage field service activities, ensuring the reliability and performance of life-saving medical devices. This role requires significant travel and offers the opportunity to m...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Drive innovative palliative care solutions for members with complex needs, providing compassionate, evidence-based support through telehealth. Collaborate with interdisciplinary teams to enhance patie...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $130K *

Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$206K - $268K *

Lead the charge in advancing nephrology clinical programs through strategic design, execution, and analysis of clinical trials, ensuring compliance with Good Clinical Practices while collaborating wit...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$172K - $232K *

Lead the charge in advancing global quality initiatives, ensuring product excellence, and fostering expertise in quality risk management while collaborating across teams to enhance compliance and oper...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Lead comprehensive medical evaluations for military applicants, ensuring compliance with health standards and regulations. Collaborate with multidisciplinary teams to assess eligibility and maintain a...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$80K - $96K *

Join a team that's dedicated to advancing anesthesiology practices, promoting CRNA autonomy in a supportive environment. Engage in diverse cases at a Level II trauma center while enjoying a flexible d...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Lead a dynamic anesthesiology team in a Level II trauma center, ensuring high-quality patient care and promoting CRNA autonomy. Collaborate effectively with anesthesiologists while managing diverse ca...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$300K *

Oversee wound management practices, providing expert care in post-acute settings. Enjoy a flexible schedule with no nights or weekends, while delivering modern treatment to patients across multiple fa...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $117K *

Drive impactful digital health solutions across multiple countries, enhancing health systems and capacity building. Collaborate with diverse teams to implement strategies that ensure sustainable healt...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$66K - $99K *

Empower patient care by delivering individualized nursing services through assessment, planning, and evaluation. Collaborate with a dedicated team to enhance skills and provide high-quality support in...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion the installation, maintenance, and repair of life-saving medical devices. Manage service activities independently within a designated region, ensuring compliance and customer satisfaction thr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $117K *

Champion integrated health initiatives across multiple countries, providing strategic oversight and leadership for malaria, maternal health, and infectious disease programs. Ensure quality interventio...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$262K - $284K *

Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$91K - $100K *

Join a team that's dedicated to excellence in clinical lab operations, overseeing staff performance and ensuring compliance with quality standards. Lead daily activities, foster team development, and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$300K *

Unlock potential by delivering expert wound management in a flexible, supportive environment. Enjoy autonomy with no nights, weekends, or call responsibilities while providing care across diverse faci...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$102K - $120K *

Join a team that's transforming healthcare analytics by bridging complex data with strategic insights. Leverage your SQL expertise and analytics engineering skills to empower stakeholders and drive va...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Elevate the patient admission process by leading a dynamic team, ensuring high-quality service, meeting quotas, and implementing best practices. This role is essential in connecting clients with criti...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Shape the future of emergency care by providing critical healthcare services in a dynamic environment. Collaborate with a multidisciplinary team to treat diverse patient needs, ensuring high-quality c...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$236K - $259K *

Join a team that advances medical knowledge and relationships in lung cancer. As a key liaison, engage with healthcare professionals, support scientific initiatives, and collaborate cross-functionally...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$378K - $420K *

Transform pharmacovigilance by leading a dedicated team, enhancing systems, and ensuring compliance across clinical and commercial products while driving safety strategy and governance...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.