Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$350K - $398K *

Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$74K - $85K *

Grow your career with a supportive nursing team dedicated to quality care, offering flexible scheduling and competitive wages. Join us in enhancing residents’ lives through expert nursing practices an...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K - $260K *

Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$167K - $229K *

Lead the charge in transforming clinical decision-making strategies within health insurance, ensuring compliance and quality in medical reviews while advancing innovation in medical management and cro...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Join a team that's dedicated to providing advanced nursing care for patients with neurological conditions. Collaborate with specialists to assess, diagnose, and manage treatment plans while supporting...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $222K *

Innovate your career with a Senior Epic Analyst role focused on designing and optimizing Epic solutions for population health and care coordination, while mentoring junior analysts and collaborating w...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $91K *

Join a dedicated team of Registered Nurses providing compassionate, patient-centered care in a fast-paced environment. Utilize your clinical skills to enhance patient outcomes and collaborate with int...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join us to lead payer contracting strategies, negotiate complex agreements, and enhance reimbursement performance across diverse healthcare models while managing a high-performing team in a dynamic, r...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $265K *

Elevate quality standards by architecting a rigorous Quality Management System for medical device launches, ensuring compliance with ISO 13485 and ISO 9001 while driving product excellence across a fa...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$120K - $145K *

Shape the future of healthcare by providing expert medical insights and support for our product portfolio. Collaborate with healthcare professionals and key opinion leaders to enhance understanding an...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Bring your expertise to the forefront of healthcare by leading innovative audit concepts and collaborating cross-functionally to uncover billing errors and optimize claims accuracy in payment processe...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$67K - $100K *

Join a team that's dedicated to delivering exceptional nursing care, developing personalized care plans, and providing holistic support to patients and families while ensuring a safe and healthy envir...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Join our dynamic healthcare team as a Biomedical Equipment Technician, ensuring the reliability and safety of networked medical devices through maintenance, inspections, and cybersecurity measures, wh...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $99K *

Play a key role in delivering exceptional service by performing preventative maintenance and troubleshooting on medical equipment. Collaborate with experienced engineers to enhance customer satisfacti...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$108K - $162K *

Join a team that's dedicated to enhancing biomedical service operations. Lead a skilled team of technicians, ensuring high-quality support and customer satisfaction across the Pacific Northwest while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$140K - $150K *

Elevate your career by providing expert dermatology consultations to veterinary professionals across North America. Leverage your skills to improve patient outcomes and support veterinarians in making...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as you manage clinical research sites, ensuring compliance and quality throughout all study phases. Build strong relationships, oversee monitoring activities, and contribute to tea...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$300K - $309K *

Transform patient care by leading medical strategy and clinical innovation. As a vital member of the team, you'll guide product development and trial execution while engaging with key stakeholders to...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Manage patient interactions and eye care procedures while fostering lasting relationships and promoting professional development. Ensure comprehensive eye health through education, diagnosis, and trea...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Unlock potential by joining a dynamic anesthesia team at a Level II Trauma Center, where you'll practice diverse techniques and collaborate closely with anesthesiologists to ensure safe, effective pat...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.