Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Transitions of Care Advanced Practice Provider (NP or PA)
$120K - $150K *
Join a team that's dedicated to enhancing patient care through comprehensive post-discharge support. As an Advanced Practice Provider, you'll manage complex cases, collaborate with interdisciplinary t...
3 weeks ago
Associate Director, Field Medical Affairs-Hematology (TN, AL, MS, AR)
$176K - $287K *
Engage with KOLs and HCPs to share scientific data on B-Cell Malignancies. Collaborate with researchers and decision-makers to drive medical strategy and support clinical trials, contributing to impac...
3 weeks ago
RN - Full Time Days - SF Village
$70K - $99K *
Provide individualized nursing care by utilizing the nursing process to assess, plan, implement, and evaluate care for residents. Collaborate with interdisciplinary teams to ensure comprehensive healt...
3 weeks ago
RN - Registered Nurse - RCC - Days
$70K - $99K *
Collaborate with healthcare teams to deliver exceptional patient care through assessment, planning, and evaluation. Utilize nursing expertise to support patients across all care phases, ensuring adher...
3 weeks ago
Director, Chronic Practice Liaison - Remote
$126K - $210K *
Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...
3 weeks ago
Onsite Care Coordination Nurse
$71K - $97K *
Pioneer the integration of comprehensive assessments and discharge planning to ensure coordinated, quality care for admitted members, enhancing health outcomes and optimizing member wellness through c...
Reposted 3 weeks ago
Senior Consultant, Fidelity Workplace Consulting - Health & Welfare
$110K - $222K *
Contribute to innovative health and welfare consulting by leading client relationships, mentoring associates, and delivering strategic solutions. Collaborate with a team of experts to enhance client e...
3 weeks ago
Clinical Trials Scientific Affairs Supervisor
$85K - $115K *
Transform clinical trial operations by leading a high-performing team, ensuring efficient RFP reviews and testing requirements. Collaborate cross-functionally to drive business objectives and enhance...
3 weeks ago
$76K - $90K *
Join a team that's enhancing healthcare through expert support of EHR systems. Lead optimization initiatives, mentor junior analysts, and collaborate with diverse teams to improve clinical and operati...
Reposted 3 weeks ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in advancing scientific operations within a dynamic team, driving global lab relationships and supporting complex clinical studies. Collaborate across functions to ensure strategic, op...
3 weeks ago
Payment Integrity Program Manager
$73K - $120K *
Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...
3 weeks ago
$100K - $120K *
Inspire healthcare excellence by providing expert pharmacy consulting, educating patients on medication use, and ensuring safety through compliance. Collaborate with a dedicated team to deliver clinic...
3 weeks ago
$100K - $120K *
Drive patient-centered pharmacy services by providing expert consultations, educating on medication use, and ensuring safety through compliance. Mentor team members while delivering clinical healthcar...
3 weeks ago
Professional Services Veterinarian Canine
$100K - $120K *
Partner with us to enhance veterinary medical support through education, training, and product expertise. Engage with veterinarians and sales teams to ensure compliance and promote American Regent Ani...
3 weeks ago
Senior Quality Operations Specialist, CAP & Monitoring
$74K - $98K *
Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...
3 weeks ago
$140K - $190K *
Champion healthcare transformation by leading client success initiatives across revenue cycle operations. Drive strategic improvements, foster innovation, and collaborate with executive leaders to enh...
3 weeks ago
$140K - $190K *
Shape the future of healthcare revenue cycle performance by leading transformative initiatives, optimizing client success, and fostering innovation across multiple healthcare partnerships. Drive measu...
3 weeks ago
Medical Review Analyst - Medicare
$66K - $106K *
Lead the charge in conducting medical record reviews and applying clinical judgment to ensure accurate claim payment decisions while supporting fraud investigations and compliance efforts...
3 weeks ago
$252K - $315K *
Champion psychiatric practice excellence by developing standards and frameworks, enhancing clinician support, and driving quality improvement initiatives to elevate patient outcomes and operational ef...
3 weeks ago
$108K - $169K *
Champion pediatric development by delivering impactful therapy in children's natural environments. Collaborate with families and interdisciplinary teams to foster independence and confidence in every...
3 weeks ago
Occupational Health Nurse - Box Elder Plant
$85K - $122K *
Transform employee health and wellness by delivering comprehensive occupational health services, ensuring compliance with safety standards, and collaborating with HR and emergency response teams to op...
3 weeks ago
$160K - $200K *
Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...
3 weeks ago
Speech Language Pathologist, Clinical Fellow - CFY
$62K - $100K *
Unlock potential by providing expert speech therapy to pediatric patients. Collaborate with a multidisciplinary team to create tailored treatment plans, ensuring optimal care and support for children...
3 weeks ago
Dental Policy & Quality Manager
$93K - $132K *
Lead the charge in developing and maintaining dental coverage policies, ensuring clinical integrity and compliance. Collaborate across teams to enhance program infrastructure and support regulatory au...
3 weeks ago
Head of Specialty Therapeutics
$252K - $315K *
Drive innovation in interventional psychiatry by developing evidence-based programs and protocols. Collaborate with clinical teams to enhance patient outcomes and ensure compliance with regulatory sta...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.