Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$92K - $138K *
Lead client provisioning operations in Revenue Cycle Management, ensuring secure and efficient access throughout the user lifecycle. Collaborate with cross-functional teams to enhance service delivery...
2 weeks ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Lead the charge in enhancing clinical documentation integrity by supervising staff, conducting quality reviews, and fostering professional development. Collaborate with teams to implement effective st...
2 weeks ago
Associate Director Precision Medicine - Clinical Diagnostics
$176K - $287K *
Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...
2 weeks ago
$90K - $120K *
Transform patient care by delivering precise teleradiology interpretations across various shifts, utilizing AI tools to enhance workflow and maintain high-quality standards while collaborating with he...
2 weeks ago
Clinical Research Associate- Wound Care Experience Required
$95K - $120K *
Elevate clinical trial success by providing expert oversight and guidance. Collaborate with cross-functional teams to ensure compliance, quality, and timely execution of monitoring activities while fo...
2 weeks ago
Quality Analyst IV - Clinical Validation Auditor (CVA), Healthcare
$85K - $110K *
Empower quality assurance by overseeing clinical audits, ensuring accuracy and consistency. Collaborate with auditors to enhance performance, mentor teams, and drive process improvements in a remote e...
2 weeks ago
Sr. Manager, Industry Relations (RPh)
$132K - $166K *
Drive impactful relationships with pharmaceutical manufacturers, leading contract negotiations and strategic initiatives to enhance specialty pharmacy access and compliance. Oversee team performance a...
2 weeks ago
$116K - $145K *
Unlock potential by leading payer negotiations and expanding access across commercial, Medicare, and Medicaid sectors. Drive strategic partnerships and ensure compliance while maximizing patient acces...
2 weeks ago
Behavioral Health Virtual Preceptor - Nurse Practitioner or Physician Assistant
$100K - $120K *
Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...
2 weeks ago
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...
2 weeks ago
Clinical Application Specialist - General Imaging (NYC)
$110K - $165K *
Elevate your career by driving clinical education and training for GI Ultrasound. Collaborate with sales and customers to enhance technical competencies, optimize workflows, and improve patient care t...
2 weeks ago
Contrast Media Clinical Sales Specialist
$97K - $146K *
Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...
2 weeks ago
Director, Nursing Inpatient Trauma
$100K - $120K *
Unlock potential by providing clinical and administrative leadership to enhance patient care standards. Collaborate with medical staff and departments to ensure compliance and drive strategic initiati...
2 weeks ago
Registered Nurse (RN) | Endoscopy
$67K - $100K *
Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing emotional support, and collaborating with healthcare professionals to enhance patie...
2 weeks ago
$67K - $100K *
Reimagine patient care by operating MRI equipment to produce diagnostic images. Collaborate with healthcare professionals to ensure efficient procedures and maintain high standards in a dynamic enviro...
2 weeks ago
$67K - $100K *
Lead the charge in delivering exceptional nursing care, developing tailored care plans, and providing holistic support to patients and families. Collaborate with healthcare teams to ensure optimal pat...
2 weeks ago
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
2 weeks ago
FSP - Clinical Team Lead - Ophthalmology - US
$135K - $147K *
Drive clinical project performance by leading teams in the execution of research trials. Collaborate with stakeholders to ensure operational excellence, manage budgets, and mitigate risks while foster...
2 weeks ago
Sr. Medical Director, Rheumatology - US Remote
$173K - $320K *
Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...
Reposted 2 weeks ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
California Collaborating Psychiatrist (Clinical & Supervisory Role)
$210K - $250K *
Join a dynamic mental health team as a Collaborating Psychiatrist, providing clinical oversight and direct patient care. Engage in meaningful collaboration with PMHNPs while ensuring compliance and de...
2 weeks ago
Managed Care Pharmacist - Managed Care/PBM
$110K - $130K *
Transform pharmacy outcomes by leading managed care initiatives that optimize clinical programs, enhance stakeholder collaboration, and drive cost efficiencies in pharmacy benefit management...
Reposted 2 weeks ago
Senior Director, Reimbursement (Oncology)
$227K - $313K *
Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...
2 weeks ago
Associate Director, Quality Assurance - Technical
$150K - $195K *
Empower quality assurance excellence by leading GMP oversight for contract manufacturing and validation projects, ensuring compliance and collaboration across technical operations to support drug deve...
2 weeks ago
$80K - $95K *
Empower our rehabilitation team by leading operations, ensuring compliance, and enhancing patient care. Drive financial success and foster strong relationships with staff and clients while maintaining...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.