Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Field Reimbursement Specialist
$94K - $148K *
Lead the charge in enhancing patient access to specialty medications by educating healthcare providers on reimbursement processes and resolving access barriers. Your expertise will bridge the gap betw...
2 weeks ago
$198K - $297K *
Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...
Reposted 2 weeks ago
Field Clinical Applications Specialist
$90K - $110K *
Elevate your career by providing expert support in molecular diagnostics, driving product implementation, and fostering strong relationships with clinical laboratories to ensure successful adoption an...
2 weeks ago
St. Louis, MO based Clinical Specialist - Remote, USA
$100K - $140K *
Transform your career by providing clinical support and training in surgical procedures. Collaborate with surgical teams to ensure optimal patient outcomes while managing inventory and compliance in a...
2 weeks ago
Lead Director Digital Product - Quality & Stars
$144K - $288K *
Pioneer innovative digital product strategies to enhance quality measures and performance in healthcare. Collaborate with multidisciplinary teams to optimize technology pathways, ensuring exceptional...
2 weeks ago
Supervisor Pharmacy | Cancer Care Institute
$85K - $100K *
Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...
Reposted 2 weeks ago
$100K - $120K *
Manage medication therapies and collaborate with healthcare teams to ensure safe, effective, and economical pharmaceutical care for patients of all ages. Lead pharmacy operations while providing mento...
Reposted 2 weeks ago
Revenue Cycle Management Transformation Manager
$78K - $113K *
Join us in transforming Revenue Cycle Management by leveraging analytical skills to enhance operational excellence across various RCM functions, driving process improvements and supporting financial p...
2 weeks ago
$110K - $130K *
Drive the development of high-quality regulatory and clinical documents, leading medical writing efforts and collaborating with cross-functional teams to ensure accuracy, clarity, and compliance with...
2 weeks ago
Manager, Market Access & Reimbursement
$145K - $218K *
Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...
2 weeks ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
Director, Neurology - Thought Leader Liaison (NORTHEAST)
$245K - $265K *
Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...
2 weeks ago
Medical Monitor (US Board-Certified Gastroenterologist)
$210K - $250K *
Innovate with us to enhance patient safety in global clinical studies. As a key medical expert, you'll provide critical input, oversee trial safety, and collaborate with teams to ensure compliance and...
2 weeks ago
$68K - $113K *
Join a team that's dedicated to transforming disability claims through expert clinical assessments. Collaborate with healthcare providers and utilize your clinical expertise to improve patient outcome...
Reposted 2 weeks ago
Field Service Engineer - Rapid City, SD
$64K - $100K *
Join a team that's dedicated to delivering exceptional service and support. As a Field Service Engineer, you'll maintain and repair innovative medical imaging products, ensuring optimal performance wh...
2 weeks ago
Field Service Engineer - Rapid City, SD
$64K - $100K *
Engage with customers as a Field Service Engineer, providing expert maintenance and repair of innovative medical imaging products. Build strong relationships while ensuring optimal performance and cus...
2 weeks ago
Field Service Engineer - Rapid City, SD
$64K - $100K *
Empower customer satisfaction by expertly maintaining and servicing innovative medical imaging products. As a Field Service Engineer, you'll travel to client sites, ensuring optimal performance and bu...
2 weeks ago
Lead Director, Risk Adjustment Performance Reporting and Insights
$100K - $231K *
Advance your career by leading healthcare analytics initiatives that transform data into impactful insights, drive performance, and enhance decision-making across departments while fostering innovatio...
Reposted 2 weeks ago
$66K - $102K *
Join a dedicated team to operate mammography equipment, ensuring quality imaging and patient care. Contribute to women's health by performing examinations, educating clients, and maintaining safety st...
2 weeks ago
Pharmacist - Avera Family Health Center - Mitchell | Ambulatory Care
$100K - $120K *
Drive optimal patient care by collaborating with healthcare teams to enhance medication therapy and improve clinical outcomes for patients with chronic conditions. Ensure safe medication management an...
2 weeks ago
$110K - $130K *
Lead the quality assurance efforts for commissioning, qualification, and validation across multiple manufacturing sites, ensuring compliance with cGMP standards while collaborating with cross-function...
2 weeks ago
Medical Science Liaison, South (Multiple Territories)
$155K - $175K *
Drive impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and ensuring successful product adoption in a dynamic prelaun...
2 weeks ago
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$80K - $175K *
Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...
Reposted 2 weeks ago
$69K - $101K *
Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...
2 weeks ago
Director, Neurology - Thought Leader Liaison (SOUTHEAST)
$245K - $265K *
Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.