Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$80K - $95K *
Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...
2 weeks ago
$190K - $300K *
Engage with scientific leaders to exchange medical insights and support research initiatives. Drive scientific discussions, enhance understanding of therapeutic areas, and foster collaboration within...
2 weeks ago
RN Operations Manager, One Medical Operations , Virtual Care Operations
$74K - $129K *
Elevate healthcare delivery by managing operations for a nationwide virtual medical team. Collaborate with leaders to optimize patient care, drive performance improvements, and implement innovative wo...
2 weeks ago
Speech Language Pathologist - Skilled Nursing - Full Time
$71K - $108K *
Unlock potential by providing expert speech and language services to clients, assessing needs, developing tailored treatment plans, and collaborating with interdisciplinary teams to enhance patient ou...
2 weeks ago
Senior Manager, Drug Safety & Pharmacovigilance
$132K - $172K *
Lead pharmacovigilance operations and safety science initiatives, ensuring compliance and quality in drug safety reporting. Oversee vendor performance, manage safety data, and contribute to regulatory...
2 weeks ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
2 weeks ago
Occupational Therapist Home Health
$80K - $95K *
Unlock potential by providing in-home occupational therapy services, evaluating safety, assessing functional needs, and implementing personalized treatment plans to enhance patient independence and qu...
2 weeks ago
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
Physical Therapist Home Health
$80K - $95K *
Elevate patient care by developing tailored rehabilitation plans, performing evaluations, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcomes and ensure...
2 weeks ago
$78K - $106K *
Transform client payment policies by ensuring accuracy and compliance. Engage with internal and external teams to manage medical policy updates, conduct analyses, and enhance client relationships whil...
2 weeks ago
$96K - $108K *
Transform patient care by joining our dynamic hospice team as a Travel RN. Provide compassionate support across multiple locations, ensuring quality and continuity of care while collaborating with loc...
2 weeks ago
Medical Review Nurse - CMS/RAC Auditor, Government Audits
$80K - $95K *
Join a team that's dedicated to enhancing healthcare quality through thorough medical claims audits. Leverage your nursing expertise in a dynamic remote environment, collaborating with experienced aud...
2 weeks ago
Clinical Supervisor (BCBA) Remote
$65K - $115K *
Transform patient care by leading clinical teams, developing treatment plans, and ensuring quality supervision to enhance skills and behaviors for individuals with autism in diverse settings. Empower...
Reposted 2 weeks ago
Associate Director, Patient Services and Distribution Case Management - Great Lakes/Northeast Region
$145K - $195K *
Engage with patients and healthcare providers to streamline access to therapy. Collaborate with internal teams and specialty pharmacies to resolve reimbursement issues and enhance patient support. Dri...
2 weeks ago
$110K - $120K *
Support a national patient community by providing critical therapy coverage across multiple states, ensuring continuity of care during clinician absences. Collaborate with multidisciplinary teams to d...
2 weeks ago
Provider Relations Supervisor - Dental
$55K - $109K *
Engage in leading the dental Provider Relations team, enhancing provider relationships and operational effectiveness. Drive network management activities to ensure member access to care and improve pr...
Reposted 2 weeks ago
$210K - $240K *
Lead strategic relationships with influential optometrists and ophthalmologists, shaping the Presbyopia ecosystem through education and engagement. Drive insights and collaboration across medical, mar...
2 weeks ago
$150K - $180K *
Contribute to the design and execution of clinical studies, ensuring data integrity and quality. Collaborate cross-functionally to drive study activities and support regulatory efforts, while enhancin...
2 weeks ago
$80K - $95K *
Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...
2 weeks ago
Head of Analytical Development, Pulmovant
$160K - $200K *
Lead the charge in analytical development, overseeing drug substance and product strategies. Collaborate across teams to ensure compliance and performance, while mentoring a high-performing analytical...
2 weeks ago
Associate Director, Drug Product, Pulmovant
$130K - $160K *
Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...
2 weeks ago
Senior Advisor, Vaccine & Clinical Case Management
$91K - $151K *
Shape the future of public health by leading the development of a statewide vaccine management and clinical case management system, ensuring seamless integration and support for local health departmen...
2 weeks ago
$110K - $130K *
Join a team that's dedicated to enhancing healthcare reporting through Epic tools. Collaborate with stakeholders to gather requirements, design reports, and provide support, ensuring successful projec...
2 weeks ago
Senior Manager, Care Management - Transitions of Care
$110K - $173K *
Champion a transformative clinical team, leading 60-70 RNs in delivering exceptional post-discharge care. Drive innovative strategies to enhance patient outcomes and foster a culture of collaboration...
2 weeks ago
Integrated Care Clinical Manager - RN - Lynn, MA
$80K - $120K *
Champion integrated care management by coordinating health services for dually-eligible enrollees with complex needs. Engage with members in community settings to enhance health outcomes and quality o...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.