Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$100K - $120K *
Transform community health by providing comprehensive dental care in a supportive environment. Collaborate with a dedicated team to enhance patient relationships and deliver high-quality services, all...
Today
$92K - $110K *
Transform community health by leading our Mobile Medical Clinic, delivering exceptional patient-centered care while supporting primary care services and public health outreach in diverse settings...
Today
Assistant Director of Nursing (ADON) - RN - Full-Time
$81K - $81K *
Elevate the quality of care by guiding nursing teams, ensuring compliance, and enhancing clinical practices. Collaborate with leadership to develop policies and provide training, fostering a culture o...
Today
Professional Services Manager (HEDIS & Risk)
$95K - $115K *
Lead the charge in managing client engagements within healthcare, translating complex data and workflows into actionable solutions. Drive customer success by fostering relationships and guiding client...
Today
FSP Clinical Research Associate II - U.S. Northeast Region - Multiple Therapies
$80K - $95K *
Champion clinical monitoring and site management processes, ensuring compliance with protocols and regulations. Develop strong relationships with investigational sites while conducting thorough assess...
Today
$92K - $110K *
Transform community health by leading our Mobile Medical Clinic, delivering exceptional patient-centered care while supporting primary care services and public health outreach in diverse settings...
Today
Clinical Consultant (Vue PACS)
$90K - $143K *
Unlock potential by serving as a clinical consultative partner, guiding healthcare customers through PACS solutions, ensuring successful implementation, and fostering strong relationships to drive cus...
Reposted today
Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Transform clinical research by leading operational oversight of studies, ensuring compliance with protocols and regulations. Collaborate with teams to drive site feasibility, manage budgets, and enhan...
Today
Licensed Practical Nurse (LPN)
$83K - $87K *
Join a dynamic team providing essential nursing care across various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives. Your expertise will support lo...
Today
Senior Clinical/Operations Internal Monitoring Manager
$129K - $168K *
Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...
Today
Medical Strategy Associate Director
$191K - $238K *
Shape the future of oncology by leading medical strategy for prostate cancer projects. Collaborate with cross-functional teams to drive scientific communication and strategic initiatives, ensuring ali...
Today
Bluespine-Savings Realization Manager
$110K - $130K *
Lead the transformation of insights into actionable savings for clients. Collaborate with employers and vendors to optimize health benefits, drive execution, and enhance product offerings while shapin...
Today
$72K - $104K *
Lead nursing operations within a correctional facility, ensuring compliance with policies and delivering high-quality patient care while supervising staff and promoting professional development in a d...
Today
Clinical Director, Clinical Development
$221K - $335K *
Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...
Today
Associate Director, Principal Medical Writer II
$120K - $145K *
Elevate your career by leading the development of high-quality clinical documents for global regulatory submissions. Collaborate with cross-functional teams to ensure data-driven messaging aligns with...
Today
Medical Education Content Manager
$85K - $115K *
Elevate healthcare education by developing evidence-based content for clinicians. Collaborate with experts to create innovative learning materials that address practice gaps and enhance professional s...
Today
Licensed Practical Nurse (LPN)
$83K - $87K *
Join a team that's dedicated to providing exceptional care in various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives as a Licensed Practical Nurse...
Today
$93K - $104K *
Unlock potential by joining our team of dedicated Registered Nurses, providing essential care in diverse settings. Enjoy flexible scheduling, competitive pay, and the opportunity to make a meaningful...
Today
Manager, Clinical Trials Start-up & Quality
$93K *
Lead clinical research initiatives, ensuring compliance and operational excellence across multisite trials. Collaborate with diverse teams to streamline processes, manage budgets, and enhance research...
Today
Director - Medical - Clinical Research Physician
$201K - $393K *
Lead the development and execution of global clinical trials for women's health compounds, collaborating with cross-functional teams to shape clinical strategies and ensure compliance with regulatory...
Reposted today
$92K - $110K *
Deliver high-quality patient-centered care as a clinical lead in mobile settings, enhancing primary care services and public health outreach within the community. Join a dedicated team focused on impr...
Today
Clinical Specialist, Philadelphia
$80K - $95K *
Empower clinical excellence by delivering expert technical support for neurovascular products. Collaborate with healthcare professionals to enhance patient care, drive product adoption, and ensure suc...
Today
$80K - $90K *
Elevate your career by building and maintaining a network of specialist consultants and physicians. Drive business growth and enhance clinical trial delivery through strong relationships and strategic...
Today
Associate Medical Director, Global Safety Physician
$184K - $253K *
Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...
Today
Utilization Management Clinician Behavioral Health Night Shift - 4 Days
$54K - $142K *
Empower your career by joining a dynamic Utilization Management team, where you'll leverage your clinical expertise to ensure timely access to behavioral health services, coordinate care, and make a m...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.