Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$90K - $100K *
Join a team that's passionate about transforming complex scientific data into engaging communications. Collaborate with cross-functional experts to deliver high-quality medical content and strategies...
Reposted 2 weeks ago
Senior Clinical Operations Manager, Canada/USA, remote
$110K - $130K *
Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...
2 weeks ago
Senior Network Development Contractor
$100K - $120K *
Drive network expansion by engaging providers and negotiating contracts to enhance Medicare services. Collaborate with a remote team to ensure network adequacy and build strong relationships with heal...
2 weeks ago
Senior Medical Science Liaisons (MSL) - Cardiovascular, Florida
$190K - $225K *
Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...
2 weeks ago
$80K - $95K *
Join a team that's dedicated to enhancing customer education and satisfaction through expert training on ultrasound products. This hybrid role involves travel and collaboration with healthcare profess...
2 weeks ago
Senior Medical Science Liaisons (MSL) - Cardiovascular, Arizona
$190K - $225K *
Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...
2 weeks ago
Field Application Specialist (Chrom/TFF) -Western Region
$90K - $116K *
Engage with customers to implement and optimize downstream processing technologies, providing technical expertise and support. Collaborate with stakeholders to enhance workflows and ensure successful...
2 weeks ago
Director, Medical Digital Solutions
$192K - $252K *
Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...
2 weeks ago
Healthcare IT Technical Operations Lead (Edifecs)
$90K - $120K *
Optimize operational excellence in healthcare IT by managing production support, driving issue resolution, and ensuring timely reporting for customer-facing technology delivery...
2 weeks ago
$100K - $120K *
Unlock potential by delivering comprehensive health assessments in patients' homes. This role requires extensive travel within a region, ensuring quality care and education while collaborating with he...
2 weeks ago
$100K - $120K *
Drive comprehensive health assessments by traveling to patients' homes, ensuring accurate documentation and patient education. Collaborate with healthcare teams to enhance care continuity while managi...
2 weeks ago
Manager, Credentialing & Medical Staff Services
$110K - $125K *
Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...
2 weeks ago
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
$78K - $206K *
Unlock potential by leading clinical performance improvement projects for Medicare Provider Collaboration groups. Collaborate with teams to enhance population health outcomes, focusing on Stars qualit...
2 weeks ago
Associate Medical Director, Renal Cancer Theranostics
$175K - $210K *
Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...
2 weeks ago
Field Reimbursement Specialist
$94K - $148K *
Optimize patient access by educating healthcare providers on reimbursement processes. As a Field Reimbursement Specialist, you'll navigate complex insurance challenges, ensuring patients receive speci...
2 weeks ago
Senior Director, Head of Clinical Pharmacology
$235K - $329K *
Lead clinical pharmacology initiatives, overseeing drug development across infectious disease and oncology programs. Collaborate with cross-functional teams to drive strategic advancements and ensure...
2 weeks ago
Director / Senior Director, Quality
$200K - $270K *
Lead the development and execution of GxP quality systems, ensuring compliance and oversight for clinical and CMC quality. Drive vendor qualification, audits, and training while fostering a culture of...
2 weeks ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
2 weeks ago
RN - Registered Nurse - Ava's Hospice House - Nights
$66K - $99K *
Elevate patient care by providing compassionate, individualized nursing in a collaborative hospice environment. Utilize your skills to manage symptoms and support families during critical times, ensur...
Reposted 2 weeks ago
$80K - $95K *
Optimize coding education and compliance for healthcare providers. Lead a team to enhance clinical documentation, develop training plans, and ensure adherence to regulations, driving improvements in b...
2 weeks ago
Manager, Coding Hospital & Physician Services
$80K - $95K *
Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...
2 weeks ago
Senior Manager, Precision Medicine - Clinical Diagnostics
$150K - $245K *
Drive the execution of companion diagnostics strategy, managing cross-functional teams and partnerships to ensure successful assay development and regulatory compliance, ultimately enhancing patient o...
2 weeks ago
Clinical Trials Medical Writer
$77K - $92K *
Join a dynamic team as a Medical Writer, where you'll interpret complex clinical protocols and create essential documentation for clinical studies, ensuring high-quality standards and regulatory compl...
2 weeks ago
Senior Manager, Payment Integrity and Provider Escalation
$110K - $150K *
Elevate payment integrity operations by leading a team focused on dispute resolution, compliance, and provider education. Drive data analysis and operational excellence to enhance collaborative relati...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.