Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted 1 week ago
MGR, Contracting - Health Plan Relations (West Region)
$95K - $115K *
Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...
1 week ago
Manager of Provider Network and Pricing Strategy
$95K - $115K *
Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...
1 week ago
$110K - $130K *
Lead the charge in optimizing drug library implementations for smart infusion pumps, collaborating with healthcare teams to enhance medication safety and workflow efficiency across mid- to large-sized...
1 week ago
Field Reimbursement Manager-Southeast
$185K - $230K *
Unlock potential by leading reimbursement strategies for rare disease therapies, integrating provider education with patient support. Collaborate cross-functionally to enhance access and navigate comp...
2 weeks ago
IBR Policy and Content Development Analyst
$85K - $110K *
Shape the future of healthcare payment integrity by developing and enhancing clinical and coding solutions. Collaborate with cross-functional teams to ensure compliance with coding standards and optim...
2 weeks ago
Manager-Clinical Informatics - Policy, Quality & Safety
$54K - $159K *
Shape the future of healthcare by leading enterprise EHR policy development and workflow standardization. Collaborate across teams to enhance patient safety and operational efficiency while assessing...
Reposted 2 weeks ago
Field Reimbursement Manager-Northeast
$185K - $230K *
Elevate patient access by managing reimbursement strategies for rare diseases. Collaborate with healthcare providers and internal teams to ensure compliance and support patient journeys through comple...
2 weeks ago
Head of Data Science & Analytics
$150K - $180K *
Inspire data-driven decision-making as you lead analytics and predictive modeling efforts. Collaborate across teams to enhance patient engagement, forecast demand, and measure impact, driving strategi...
2 weeks ago
Ultrasound Technologist- Women's Health Reproductive Clinic- FT
$66K - $102K *
Transform patient care by performing diagnostic ultrasounds in a dynamic reproductive medicine clinic. Collaborate with a skilled team to deliver high-quality imaging and support fertility treatments...
Reposted 2 weeks ago
Director of Insurance Plan Management
$120K - $150K *
Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...
2 weeks ago
Medical Director (Publications)
$130K - $150K *
Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...
Reposted 2 weeks ago
Field Clinical Manager (Remote)
$175K - $230K *
Empower healthcare innovation by leading a team of Field Clinical Specialists. Drive the successful launch of the Globe Pulsed Field System through training, support, and relationship-building with he...
2 weeks ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
2 weeks ago
Remote Body Radiologist - Days - Radiology Partners Indiana (Tort Reform State)
$500K+*
Unlock your potential in a fully remote role focusing on body and general radiology. Join a dynamic team, enjoy competitive compensation, and benefit from advanced technology in a supportive environme...
2 weeks ago
Vice President, CMC Development and Drug Delivery Innovation
$272K - $340K *
Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...
2 weeks ago
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
2 weeks ago
Senior Clinical Advisor, Age-Friendly Health Systems
$250K - $325K *
Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...
2 weeks ago
Supervising Physician - Dermatology (Remote)
$210K - $250K *
Lead the charge in providing remote clinical oversight for Dermatology PAs, ensuring high-quality patient care and compliance with regulations. Collaborate with a dedicated team to foster clinical exc...
2 weeks ago
Revenue Cycle Managed Services - Billing Manager (Hospital System)
$100K - $120K *
Transform billing operations by leading a team to optimize healthcare revenue cycle processes, ensuring timely and accurate claims submission while driving performance improvements and fostering stron...
2 weeks ago
Associate Medical Director (Promotional Medical Education)
$100K - $125K *
Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...
Reposted 2 weeks ago
Virtual Telehealth Nurse Practitioner
$100K - $120K *
Elevate patient care by delivering virtual health services, ensuring compliance with regulations, and fostering teamwork in a dynamic environment. Utilize your expertise to provide accurate diagnoses...
2 weeks ago
Patient Programming / Ambassador Manager
$205K - $228K *
Champion patient-focused initiatives by leading strategy and execution of ambassador programs. Build relationships with patients and advocacy groups to enhance engagement and ensure their voices shape...
2 weeks ago
21GRAMS- VP, Medical Strategy Director
$180K - $195K *
Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...
Reposted 2 weeks ago
Field Reimbursement Manager-Atlantic
$185K - $230K *
Shape the future of patient access by leading reimbursement strategies and support for rare disease therapies. Collaborate cross-functionally to enhance provider education and patient understanding, e...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.