Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Dialysis Home Therapies Nurse (RN)
$74K - $99K *
Elevate your nursing career by coordinating home dialysis programs, ensuring top-notch patient care through collaboration and education. Join a dedicated team focused on improving lives with innovativ...
1 week ago
Section Chief, Abdominal / Body Imaging
$300K - $350K *
Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...
1 week ago
Clinical Success Manager, Dosimetrist
$135K - $155K *
Join a team that's dedicated to enhancing clinical workflows in Radiation Oncology. As a Clinical Success Manager, you'll train clinics, solve problems, and foster relationships to ensure customer sat...
1 week ago
$77K - $85K *
Join a dedicated team to enhance clients' independence and quality of life through tailored occupational therapy interventions. Collaborate in a supportive environment, focusing on daily living skills...
1 week ago
$100K - $120K *
Join a dynamic team to provide expert pharmacy consulting, educate patients on medications, and deliver clinical healthcare services while ensuring safety and compliance. Mentor colleagues and enhance...
1 week ago
Senior Clinical Research Associate/Clinical Research Associate II - US Any Region - FSP
$95K - $115K *
Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...
1 week ago
Director, Medical Affairs - Emerging Therapies
$175K - $210K *
Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...
1 week ago
Quality Control Specialist, Medical Writing
$74K - $99K *
Shape the future of regulatory submissions by ensuring high-quality QC reviews of clinical documents. Collaborate with global teams to meet project timelines while maintaining compliance with industry...
Reposted 1 week ago
Healthcare Regulatory Assurance Lead
$119K - $175K *
Optimize healthcare compliance by leading regulatory assurance efforts, ensuring adherence to HIPAA, HITECH, and HITRUST standards while collaborating with clinical leadership to maintain a defensible...
1 week ago
$90K - $141K *
Champion patient care by leading a dedicated team in an outpatient clinic. Drive operational excellence, enhance patient relationships, and foster a culture of growth while managing clinic performance...
1 week ago
$105K - $125K *
Transform coding quality and efficiency as a senior expert in radiology coding. Collaborate with cross-functional teams to enhance processes, provide guidance, and drive best practices, ensuring excep...
1 week ago
Associate Director, Field Medical Affairs Cutaneous Oncology (Pacific Northwest)
$176K - $287K *
Shape the future of oncology by cultivating relationships with KOLs, providing critical insights, and supporting research initiatives. Drive awareness and education while ensuring compliance and integ...
1 week ago
$210K - $250K *
Empower oncology research by leveraging real-world evidence and clinical expertise. Collaborate with cross-functional teams to develop innovative solutions that enhance cancer treatment and support bi...
1 week ago
Field Medical Excellence & Operations
$210K - $255K *
Shape the future of cancer treatment by leading Field Medical Excellence initiatives. Drive operational improvements, strategic planning, and cross-functional collaboration to enhance the impact of ou...
1 week ago
Senior Regional Pharmacy Consultant
$95K - $115K *
Join a dynamic team as a Senior Regional Pharmacy Consultant, driving client growth and retention through strategic pharmacy benefits expertise. Collaborate with market leaders and provide consultativ...
1 week ago
$175K - $250K *
Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...
1 week ago
Manager, AI & Workflow Operations - Licensed (RN, NP, PA, or MD, RPh, PharmD)
$100K - $120K *
Transform healthcare delivery by leading operations for a growing telehealth practice. Collaborate with clinical teams to enhance patient care through innovative solutions and efficient workflows, ens...
1 week ago
EHR Application Analyst - Senior
$78K - $104K *
Inspire efficient EHR system performance by leading applications analysis and optimization. Drive project management and collaboration while mentoring team members and enhancing patient care through e...
Reposted 1 week ago
Manager Professional Billing Coding Operations - Remote
$78K - $113K *
Join us to lead the Professional Coding Operations team, ensuring accurate coding practices and compliance. Collaborate with stakeholders, mentor staff, and drive improvements in coding efficiency and...
1 week ago
Director, Global Real-World Evidence & Health Outcomes Scientist, Oncology
$204K - $340K *
Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...
1 week ago
Quality of Care and Clinical Review Nurse
$69K - $125K *
Join a dynamic team to oversee quality of care investigations and improvement initiatives, ensuring compliance with regulatory standards while enhancing patient outcomes and organizational efficiency...
1 week ago
$130K - $150K *
Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...
1 week ago
Specialist, Clinical Implementations (Clinical Licensure Required) - REMOTE
$80K - $95K *
Innovate clinical system implementations by ensuring seamless integration of technologies and workflows. Collaborate with clinical and technical teams to enhance patient care and operational efficienc...
1 week ago
$210K - $250K *
Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...
1 week ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.