Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Consultant, Healthcare Finance (Healthcare & Medicaid Finance and Analysis)
$95K - $130K *
Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...
1 week ago
$69K - $101K *
Unlock potential by delivering comprehensive clinical care management services, enhancing health outcomes for diverse populations through assessment, care planning, and coordination across multiple he...
1 week ago
Senior Medical Science Liaison, West (Multiple Territories)
$190K - $220K *
Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...
1 week ago
Senior Medical Science Liaison, Southeast (Multiple Territories)
$190K - $220K *
Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...
1 week ago
Clinical Applications Specialist - Dosimetrist (Travelling position)
$123K - $169K *
Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...
1 week ago
Clinical Lead - Senior Site Activation Lead
$116K *
Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...
1 week ago
Clinical Lead - Site Activation Lead
$116K *
Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...
1 week ago
Manager, Payment Integrity - REMOTE
$95K - $115K *
Transform payment integrity operations by leading a dedicated team to enhance recovery processes, ensure compliance, and drive continuous improvement while achieving optimal performance and quality st...
1 week ago
$95K - $115K *
Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...
Reposted 1 week ago
Pharmacy Operations Optimization Manager - KitCheck
$110K - $125K *
Shape the future of pharmacy operations by optimizing customer engagement and operational performance across a national portfolio. Drive proactive interventions and enhance workflow efficiency to ensu...
1 week ago
Privacy Program Optimization Manager - PrivacyPro
$110K - $125K *
Elevate customer engagement by optimizing privacy program performance across a diverse portfolio. Ensure proactive intervention and support for healthcare privacy teams, driving compliance and enhanci...
1 week ago
Senior Medical Science Liaison, South (Multiple Territories)
$190K - $220K *
Engage with key stakeholders as a Senior Medical Science Liaison, driving prelaunch and launch strategies. Build trusted relationships, deliver scientific insights, and influence adoption in a dynamic...
1 week ago
Sr. Manager, Provider Data Operations & Attribution Integrity
$67K - $199K *
Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...
1 week ago
Epic Application Analyst - Beacon
$80K - $95K *
Drive the design, build, testing, and support of applications, ensuring optimal functionality and user satisfaction while collaborating with interdisciplinary teams to enhance workflows and resolve co...
1 week ago
Registered Nurse (RN) | Emergency Unit
$67K - $100K *
Transform patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure optimal health outcomes while providing emotional and spir...
1 week ago
Manager, Patient Services - Client Program Mgmt, Patient Access
$102K - $130K *
Lead the charge in optimizing patient services through effective team management, strategic collaboration, and continuous improvement initiatives. Drive operational efficiencies while ensuring high-qu...
1 week ago
$110K - $130K *
Drive medication therapy management services by conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient care through...
1 week ago
RCM Implementation Consultant - EHR/SaaS/Healthcare IT/PT
$80K - $95K *
Manage the implementation process for clients in Revenue Cycle Management, ensuring efficient setup and optimization of billing workflows. Serve as the primary expert, guiding healthcare organizations...
1 week ago
Director, Medical Science Liaison (East)
$148K - $222K *
Drive clinical adoption and enhance partnerships by leading a high-performing Medical Science Liaison team. Collaborate with sales and medical teams to educate stakeholders, influence decision-making...
1 week ago
Remote Breast Radiologist - RP Eagle
$250K - $300K *
Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...
1 week ago
$66K - $99K *
Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...
1 week ago
Director, Nursing and Clinical Services
$100K - $120K *
Lead the charge in delivering high-quality rural healthcare by overseeing nursing and clinical operations. Engage with staff and patients to ensure compliance and enhance patient care standards in a d...
1 week ago
Customer Care Veterinary Technician
$72K - $104K *
Unlock your potential by delivering exceptional customer support in veterinary care. Engage with clients, resolve inquiries, and ensure compliance with industry standards while collaborating with inte...
1 week ago
Patient and Site Engagement Lead (US/UK)
$90K - $178K *
Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...
Reposted 1 week ago
Risk and Central Monitoring Associate Manager
$65K - $130K *
Contribute to clinical trial success by leading risk management and central monitoring activities. Collaborate with cross-functional teams to ensure compliance with ICH GCP guidelines and enhance qual...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.