Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$145K - $165K *

Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$72K - $90K *

Join a team that's dedicated to delivering high-quality MRI examinations, utilizing advanced imaging techniques while ensuring patient comfort and safety. Collaborate in a professional environment foc...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the charge in optimizing payment integrity programs, ensuring effective execution and performance monitoring. Collaborate across functions to drive improvements in operational efficiency and prov...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$182K - $247K *

Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$61K - $104K *

Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$78K - $113K *

Innovate healthcare fraud prevention by leading complex investigations, evaluating medical necessity, and collaborating with regulatory agencies to ensure quality member care and safeguard plan assets...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$78K - $113K *

Unlock potential by leading complex investigations into healthcare fraud, waste, and abuse. Collaborate with regulatory agencies and internal teams to ensure compliance and safeguard member care while...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$93K - $134K *

Drive impactful data mining initiatives by analyzing complex claims across Medicare, Medicaid, and Commercial sectors. Leverage your expertise to identify anomalies and enhance recovery opportunities...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in directing clinical rehabilitation operations across multiple practices, ensuring quality patient care and achieving financial and operational objectives through effective management...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Accelerate progress at the forefront of clinical research by managing site operations, ensuring compliance, and fostering strong relationships throughout study phases. Your expertise will drive site p...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $153K *

Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform community health by providing comprehensive dental care in a supportive, team-oriented environment. Enjoy a fulfilling role with no weekends or call, fostering long-lasting patient relations...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$76K - $106K *

Elevate patient care by supervising nursing operations and enhancing clinical processes. Collaborate with a dedicated team to ensure quality outcomes and maintain effective relationships within a dyna...

Today

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$64K - $96K *

Join a team that's dedicated to delivering exceptional nursing care by developing personalized care plans, providing comprehensive support, and collaborating with healthcare professionals to enhance p...

Today

  •   Less than 5 years exp.  •   Healthcare

$73K - $98K *

Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$144K - $240K *

Transform healthcare delivery by leading strategic initiatives and optimizing infusion services. Drive client success through expert guidance, operational excellence, and innovative solutions, ensurin...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in ensuring food safety through comprehensive audits, collaborating with teams to uphold certification standards, and providing expert recommendations for compliance and improvement in...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Shape the future of dental care by joining a dedicated team to provide comprehensive services, build lasting patient relationships, and enhance community health in a supportive, mission-driven environ...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$114K - $210K *

Champion the development of regulatory documents for global submissions, managing timelines and cross-functional collaboration to ensure quality and compliance with industry standards while mentoring...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Transform community health by providing comprehensive dental care in a supportive environment. Collaborate with a dedicated team to enhance patient relationships and deliver high-quality services, all...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.