Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$165K - $194K *

Pioneer impactful scientific exchanges as a Senior Medical Science Liaison, fostering relationships with healthcare providers and key opinion leaders in hematology/oncology while supporting Rigel's in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $258K *

Unlock your potential as a Senior Engagement Manager, leading complex consulting projects for pharmaceutical clients. Drive strategic medical initiatives, foster client relationships, and mentor teams...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $250K *

Shape the future of neurology by building partnerships with Medical Experts, generating insights, and collaborating across teams to enhance patient care and drive innovation in a dynamic healthcare la...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in labeling and nutrition compliance, overseeing the source-to-label process, ensuring regulatory adherence, and managing cross-functional deliverables to maintain product integrity an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$141K - $204K *

Drive strategic growth for DSD by leveraging data, analytics, and tools to enhance operational performance and achieve expansion goals. Collaborate with leadership to support initiatives that elevate...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $155K *

Empower individuals by providing evidence-based mental health support to patients aged 13+. Collaborate with a dedicated clinical team in a fully remote environment, enhancing patient care and profess...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $110K *

Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$67K - $100K *

Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$153K - $268K *

Join a team that's advancing regulatory strategies for drug substance manufacturing. Lead the charge in selecting and justifying Regulatory Starting Materials, ensuring compliance with global guidelin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Champion patient care by performing interventional radiology procedures under supervision. Collaborate with a multidisciplinary team to assess, diagnose, and manage health concerns, ensuring optimal o...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$98K - $132K *

Transform healthcare by leading Risk Adjustment strategies and educational initiatives. Collaborate with teams to enhance coding accuracy and documentation, ensuring compliance and delivering impactfu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$190K - $220K *

Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$111K - $159K *

Lead clinical operations in review of medical certifications for leave requests. Build and manage a dedicated team, standardize workflows, and ensure compliance while driving continuous improvements i...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $170K *

Join a team that's dedicated to advancing tuberculosis (TB) prevention and care. As a senior technical advisor, you'll lead innovative strategies, collaborate with global partners, and enhance TB prog...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$64K - $96K *

Deliver exceptional nursing care by utilizing the nursing process to assess, plan, implement, and evaluate patient outcomes in home and facility settings, ensuring adherence to clinical standards and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $250K *

Unlock potential by leading innovative clinical documentation initiatives that enhance quality, compliance, and revenue cycle outcomes. Collaborate with cross-functional teams to redefine workflows an...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $240K *

Optimize coding workflows by leveraging your 10+ years of leadership in coding, compliance, and revenue cycle management. Collaborate with AI and engineering teams to drive innovation and enhance oper...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $130K *

Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $101K *

Unlock potential by delivering comprehensive clinical care management services, enhancing health outcomes for diverse populations through assessment, care planning, and coordination across multiple he...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$190K - $220K *

Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $220K *

Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $169K *

Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$116K *

Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.