Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$65K - $98K *

Reimagine service excellence by diagnosing and repairing complex biomedical equipment, ensuring safety and compliance, and fostering strong relationships with customers and teams to drive overall sati...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Business Services

$207K - $225K *

Drive business growth and customer satisfaction by leading a high-performing Cardiovascular Clinical Solutions Consultant team, collaborating across sales and clinical operations to enhance customer e...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $160K *

Contribute to malaria programming by providing technical leadership and support to country teams, ensuring quality interventions, compliance, and strategic resource investments across health facilitie...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$74K - $87K *

Unlock patient access by managing the insurance verification process, addressing barriers to care, and ensuring seamless coordination among stakeholders to facilitate timely therapy access and support...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$133K - $237K *

Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$67K - $100K *

Elevate patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal heal...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $169K *

Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$152K - $254K *

Shape the future of behavioral health by leading clinical programs, driving strategic initiatives, and fostering cross-functional partnerships to enhance member outcomes and operational excellence...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$79K - $127K *

Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$240K - $300K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $92K *

Engage in impactful virtual counseling for patients with acute mental health conditions. Develop treatment plans, exercise clinical judgment, and collaborate with multidisciplinary teams to enhance be...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$120K - $130K *

Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Technical Services

$250K - $300K *

Explore a rewarding career as a Diagnostic Radiologist, supporting growth in Wilkes-Barre and Scranton. Join a respected practice with modern technology, excellent procedural volume, and opportunities...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $200K *

Join a dynamic team to conduct comprehensive eye exams and diagnose ocular conditions using innovative technology. Educate patients on eye care and develop personalized treatment plans in a hybrid wor...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$203K - $253K *

Strategize and lead patient advocacy and medical education initiatives, fostering collaboration with stakeholders to enhance patient engagement and inform Medical Affairs strategies. Drive impactful i...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$126K - $153K *

Lead the charge in transforming healthcare safety cultures by applying High Reliability Organization principles, enhancing patient trust, and driving data-driven process improvements across clinical s...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$216K - $243K *

Pioneer advancements in vaccine research and development, driving global immunization efforts. Collaborate across teams to ensure compliance and effective delivery of safe vaccines, enhancing public h...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the execution of clinical trials by monitoring site activities, ensuring compliance with regulations, and collaborating with teams to achieve study objectives. Play a key role in training site st...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K *

Empower patients by delivering exceptional eye care solutions. Conduct comprehensive exams, diagnose conditions, and create personalized treatment plans in a dynamic, patient-centered environment that...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$260K - $270K *

Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$145K - $155K *

Join a team that's dedicated to providing virtual behavioral health services to military personnel. Utilize your expertise in clinical psychology to deliver evidence-based treatments and support patie...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $120K *

Transform healthcare delivery by providing emergency and primary care at remote worksites. Collaborate with clinical teams to ensure quality assurance and support field staff while maintaining essenti...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $153K *

Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.