Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
RN Nurse Clinical Documentation Improvement Specialist
$114K *
Advance clinical documentation quality by conducting thorough reviews and facilitating physician interactions to enhance accuracy and compliance in medical records, ensuring optimal patient care and r...
5 days ago
Early Careers New Grad - Leadership Development Program (REMOTE)
$63K - $114K *
Unlock your potential by supporting strategic projects and planning in health care. Collaborate with diverse teams to drive business goals, enhance analytical capabilities, and develop innovative solu...
Reposted 5 days ago
$60K - $132K *
Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...
Reposted 5 days ago
$150K - $180K *
Transform clinical research practices by guiding study design and analysis. Collaborate with cross-functional teams to deliver key insights and evidence that drive product innovation in the healthcare...
Reposted 5 days ago
$120K - $145K *
Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...
Reposted 5 days ago
Medicaid DSH Payment Analysis Specialist
$95K - $105K *
Elevate Medicaid program effectiveness by analyzing DSH payments, ensuring compliance, and collaborating with hospitals and government stakeholders to deliver precise, timely results that enhance heal...
5 days ago
Director Service Coordination and Long-Term Services and Supports, Geisinger Health Plan
$110K - $130K *
Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...
5 days ago
Physical Medicine and Rehabilitation Medical Director
$206K - $413K *
Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...
Reposted 5 days ago
$115K - $149K *
Drive strategic payer partnerships and enhance revenue cycle performance through oversight, mentorship, and data analysis. Collaborate across teams to resolve complex issues and improve operational ef...
Reposted 5 days ago
Case Manager - Healthcare Appeals & Patient Access Advocate
$83K - $112K *
Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...
Reposted 5 days ago
Clinical Development Associate
$92K - $120K *
Elevate clinical trial execution by supporting the development team in data review, safety tracking, and cross-functional collaboration to advance innovative clinical programs in ophthalmology...
5 days ago
Dir, EHR Revenue Cycle Applications
$141K - $211K *
Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...
5 days ago
Advisor, Bio Sample Operations - DMPK
$153K - $268K *
Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...
5 days ago
Sr. Reimbursement Analyst (Ops) - Remote
$101K - $152K *
Unlock your potential by supporting reimbursement operations and strategic initiatives that enhance patient access across diverse therapies. Collaborate with cross-functional teams to drive process im...
Reposted 5 days ago
In-Home Health - Nurse Practitioner or Physician Assistant (Full Time) - Onondaga, NY
$95K - $206K *
Advance health outcomes by providing in-home evaluations, fostering trust and personalized care. Engage with patients to bridge gaps in health services, ensuring comprehensive support tailored to indi...
5 days ago
$93K - $123K *
Join a team that's dedicated to enhancing patient safety and compliance through effective case management. This role involves coordinating complex healthcare cases, collaborating with stakeholders, an...
5 days ago
$67K - $108K *
Transform patient care by performing echocardiography tests and procedures, ensuring adherence to industry standards. Collaborate with healthcare professionals while providing exceptional service in a...
6 days ago
$160K - $200K *
Elevate patient care by administering anesthesia and collaborating with healthcare teams. Develop pre-anesthetic plans, monitor patients, and ensure safety during procedures while communicating effect...
6 days ago
$160K - $200K *
Administer anesthesia and sedation for diverse procedures, develop pre-anesthetic plans, collaborate with healthcare teams, and monitor patient responses to ensure optimal care and safety throughout s...
6 days ago
RN - Registered Nurse - Medical Oncology - Rotating
$66K - $99K *
Accelerate progress at delivering patient-focused care in a dynamic 43-bed unit. Collaborate with an interdisciplinary team to provide specialized nursing services across various medical and surgical...
6 days ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, collaborating with interdisciplinary teams to enhance health outcomes. Thrive in a supportive environment that values teamwork, professionalism...
6 days ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise to enhance health outcomes. Collaborate with interdisciplinary teams in a dynamic environment, ensuring quality and...
6 days ago
$76K - $96K *
Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...
6 days ago
Clinical Pharmacist - Value Based Care
$110K - $130K *
Unlock potential by leading a remote pharmacy program focused on medication adherence. Collaborate with a specialized team to enhance patient care through data-driven strategies and operational suppor...
6 days ago
$110K - $130K *
Join a dynamic team providing empathetic pharmacy consulting and clinical services. Oversee pharmacy operations, enhance patient experiences, and manage staff performance while ensuring compliance wit...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.