Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$114K *

Advance clinical documentation quality by conducting thorough reviews and facilitating physician interactions to enhance accuracy and compliance in medical records, ensuring optimal patient care and r...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$63K - $114K *

Unlock your potential by supporting strategic projects and planning in health care. Collaborate with diverse teams to drive business goals, enhance analytical capabilities, and develop innovative solu...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $132K *

Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform clinical research practices by guiding study design and analysis. Collaborate with cross-functional teams to deliver key insights and evidence that drive product innovation in the healthcare...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $105K *

Elevate Medicaid program effectiveness by analyzing DSH payments, ensuring compliance, and collaborating with hospitals and government stakeholders to deliver precise, timely results that enhance heal...

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $149K *

Drive strategic payer partnerships and enhance revenue cycle performance through oversight, mentorship, and data analysis. Collaborate across teams to resolve complex issues and improve operational ef...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $112K *

Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $120K *

Elevate clinical trial execution by supporting the development team in data review, safety tracking, and cross-functional collaboration to advance innovative clinical programs in ophthalmology...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$141K - $211K *

Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$153K - $268K *

Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$101K - $152K *

Unlock your potential by supporting reimbursement operations and strategic initiatives that enhance patient access across diverse therapies. Collaborate with cross-functional teams to drive process im...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $206K *

Advance health outcomes by providing in-home evaluations, fostering trust and personalized care. Engage with patients to bridge gaps in health services, ensuring comprehensive support tailored to indi...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$93K - $123K *

Join a team that's dedicated to enhancing patient safety and compliance through effective case management. This role involves coordinating complex healthcare cases, collaborating with stakeholders, an...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$67K - $108K *

Transform patient care by performing echocardiography tests and procedures, ensuring adherence to industry standards. Collaborate with healthcare professionals while providing exceptional service in a...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Elevate patient care by administering anesthesia and collaborating with healthcare teams. Develop pre-anesthetic plans, monitor patients, and ensure safety during procedures while communicating effect...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Administer anesthesia and sedation for diverse procedures, develop pre-anesthetic plans, collaborate with healthcare teams, and monitor patient responses to ensure optimal care and safety throughout s...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $99K *

Accelerate progress at delivering patient-focused care in a dynamic 43-bed unit. Collaborate with an interdisciplinary team to provide specialized nursing services across various medical and surgical...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $91K *

Lead compassionate patient care as a Registered Nurse, collaborating with interdisciplinary teams to enhance health outcomes. Thrive in a supportive environment that values teamwork, professionalism...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $91K *

Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise to enhance health outcomes. Collaborate with interdisciplinary teams in a dynamic environment, ensuring quality and...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $96K *

Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading a remote pharmacy program focused on medication adherence. Collaborate with a specialized team to enhance patient care through data-driven strategies and operational suppor...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team providing empathetic pharmacy consulting and clinical services. Oversee pharmacy operations, enhance patient experiences, and manage staff performance while ensuring compliance wit...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.