Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$210K *

Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $83K *

Help us advance hearing solutions by providing clinical and sales support across North and Central Virginia. Join a dedicated team and develop expertise in cochlear implants while building strong cust...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $180K *

Drive impactful healthcare technology solutions through data-driven strategies, optimize customer engagements with compelling insights, and foster long-term partnerships for strategic growth...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $113K *

Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Analyze provider network data to ensure accuracy and compliance. Collaborate with teams to maintain critical information, generate reports, and support quality improvement initiatives in provider admi...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Champion quality performance initiatives by leading complex data analysis and project management efforts. Collaborate with cross-functional teams to enhance healthcare quality, ensuring compliance wit...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $92K *

Join our team to enhance healthcare quality through precise coding audits, mentoring coders, and driving process improvements. Your expertise will help shape compliance and accuracy in outpatient serv...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$79K - $91K *

Transform healthcare delivery by leading the RN UM Team, ensuring timely care decisions and maintaining documentation quality while fostering a culture of clinical excellence and accountability...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $135K *

Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$202K - $250K *

Elevate the Personal Care department by driving strategic billing and claims initiatives, optimizing processes for accuracy and compliance, and leading a high-performing team to achieve operational ex...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $115K *

Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $81K *

Transform healthcare delivery by guiding nursing teams and ensuring compliance with regulations. Leverage your expertise to enhance clinical practices, train staff, and implement policies that elevate...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$114K *

Advance clinical documentation quality by conducting thorough reviews and facilitating physician interactions to enhance accuracy and compliance in medical records, ensuring optimal patient care and r...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$63K - $114K *

Unlock your potential by supporting strategic projects and planning in health care. Collaborate with diverse teams to drive business goals, enhance analytical capabilities, and develop innovative solu...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $132K *

Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform clinical research practices by guiding study design and analysis. Collaborate with cross-functional teams to deliver key insights and evidence that drive product innovation in the healthcare...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $105K *

Elevate Medicaid program effectiveness by analyzing DSH payments, ensuring compliance, and collaborating with hospitals and government stakeholders to deliver precise, timely results that enhance heal...

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.