Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Supervisory Pharmacist (Clinical)
$100K - $120K *
Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...
Reposted 3 days ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
$95K - $115K *
Optimize patient access workflows by aligning registration with revenue cycle needs. Collaborate with stakeholders to enhance eligibility processes and improve patient estimates, while mentoring IS st...
3 days ago
Virtual Utilization Review Supervisor
$84K - $126K *
Lead the charge in enhancing patient care through effective utilization review, ensuring quality and compliance while collaborating with healthcare teams to optimize clinical outcomes and financial pe...
3 days ago
$80K - $95K *
Drive revenue cycle operations by managing processes from entry to adjudication. Lead teams, implement efficiencies, and ensure compliance while optimizing cash collections and performance metrics for...
Reposted 3 days ago
RN/Medical Services Coordinator
$81K - $87K *
Join us to lead and support a dedicated team in delivering exceptional medical services. Oversee case management, coordinate healthcare access, and empower individuals to achieve their health goals wh...
3 days ago
Physician (Diagnostic Radiologist)
$210K - $250K *
Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...
3 days ago
Product Quality Complaints Manager
$112K - $140K *
Transform product quality management by leading complaint intake, investigation, and resolution processes. Collaborate with cross-functional teams to ensure compliance and enhance patient safety while...
3 days ago
Associate Optometrist ( Sioux Falls, SD) Lenscrafters
$80K - $95K *
Drive exceptional patient care by leading practices while collaborating with your team to exceed performance metrics and establish a reputation as the leading optical provider in the community. Inspir...
Reposted 3 days ago
Clinical Territory Manager, Diabetes (Arlington, VA)
$76K - $128K *
Empower healthcare professionals and patients by providing expert education on diabetes management. Collaborate with sales teams to enhance territory growth and ensure optimal patient experiences whil...
3 days ago
Manager, Quality Assurance - Western U.S. (West of the Mississippi) & Florida
$123K - $160K *
Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...
3 days ago
Managed Care Contracting and Performance Advisor
$113K - $188K *
Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...
3 days ago
Clinical Research Associate II
$90K - $110K *
Unlock potential by overseeing clinical trials, ensuring compliance with protocols and regulations. Collaborate with investigators and coordinators to protect participant rights and verify data integr...
3 days ago
Medical Science Liaison /Senior Medical Science Liaison - Specialty - Northeast Region
$162K - $203K *
Transform your career by engaging with key opinion leaders in Urology and Women's Health. Leverage your scientific expertise to drive medical strategies and foster relationships that enhance product u...
3 days ago
Lead Consultant CDH Implementation
$105K - $149K *
Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...
3 days ago
$81K - $110K *
Lead the transformation of patient care by enhancing utilization review processes, ensuring quality documentation, and collaborating with healthcare teams to optimize clinical outcomes and financial p...
3 days ago
Senior Manager / Associate Director, Medical Information
$165K - $210K *
Drive the Medical Information strategy for infigratinib, ensuring high-quality, compliant content delivery. Collaborate cross-functionally to support scientific exchange and operational excellence in...
3 days ago
Executive Director Access Services - Immunology
$255K - $424K *
Lead the development and execution of Immunology access services strategy, ensuring seamless patient and provider experiences. Collaborate cross-functionally to enhance reimbursement initiatives and d...
3 days ago
Patient Access Liaison - Remote
$110K - $130K *
Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...
3 days ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
Registered Nurse (RN) | OR | Surgery
$64K - $96K *
Join a dedicated team providing compassionate nursing care, developing tailored patient care plans, and collaborating with healthcare professionals to ensure positive health outcomes in a dynamic oper...
Reposted 3 days ago
Strategic ABA Practice Partner
$100K - $120K *
Unlock potential by partnering with ABA practice owners to enhance operations, drive growth, and improve performance. Collaborate closely with providers to navigate challenges and implement strategic...
3 days ago
Medical Science Liaison - Senior Medical Liaison - Mid Atlantic Region
$162K - $203K *
Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...
3 days ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 3 days ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.