Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$87K - $151K *

Unlock potential by providing expert remote clinical applications support for advanced molecular imaging. Leverage your clinical knowledge and customer service skills to enhance productivity and deliv...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$91K - $137K *

Shape the future of clinical research by managing site operations, ensuring patient safety, and maintaining data integrity. Collaborate with study teams to oversee monitoring activities and drive succ...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$91K - $137K *

Empower your career by managing clinical research sites, ensuring patient safety, and maintaining data integrity. Collaborate with teams to oversee study implementation and monitoring, while enhancing...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join us to lead a dynamic team in optimizing revenue cycle operations for multiple clients. Drive continuous improvement and ensure client satisfaction while managing performance metrics and fostering...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $111K *

Partner with us to transform patient care in advanced cochlear implant solutions. Build trusted relationships, execute strategic plans, and improve outcomes by leveraging clinical expertise and consul...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $215K *

Empower innovation in ophthalmic device development by leading global clinical strategies for surgical programs, from feasibility to regulatory submissions. Collaborate cross-functionally to drive pro...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $165K *

Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $203K *

Join a team that's transforming digital tinnitus care in the U.S. by leading commercial execution across healthcare sectors. Drive adoption and optimize partnerships to enhance patient engagement and...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$190K - $240K *

Lead the end-to-end revenue cycle operations, driving improvements in eligibility, coding, and claims management. Collaborate with teams to enhance workflows and ensure accountability, while evaluatin...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $97K *

Empower individuals by coordinating personalized care plans for seniors and members with disabilities. Collaborate with healthcare providers and manage caseloads while enjoying a flexible, remote work...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $105K *

Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $200K *

Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $108K *

Join a dynamic team to provide essential data management and help desk support for public health initiatives, ensuring effective communication and technical assistance for healthcare facilities and us...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $108K *

Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$113K - $133K *

Shape global health initiatives by managing HIV programs, coordinating with stakeholders, and ensuring timely reporting. This role offers hands-on experience in public health, ideal for detail-oriente...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$174K - $217K *

Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K *

Lead the charge in auditing inpatient claims, ensuring coding accuracy and clinical validation. Utilize advanced coding expertise to analyze claims independently, while meeting productivity and qualit...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Engage with patients as a Virtually Integrated Care RN, providing essential remote support and care coordination. Utilize advanced clinical skills to assess needs, develop care plans, and enhance pati...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$199K - $269K *

Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$191K - $258K *

Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.