Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$87K - $151K *
Unlock potential by providing expert remote clinical applications support for advanced molecular imaging. Leverage your clinical knowledge and customer service skills to enhance productivity and deliv...
2 days ago
Senior Consultant - Regulatory
$110K - $130K *
Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...
Reposted 2 days ago
Clinical Research Associate II - FSP
$91K - $137K *
Shape the future of clinical research by managing site operations, ensuring patient safety, and maintaining data integrity. Collaborate with study teams to oversee monitoring activities and drive succ...
2 days ago
Clinical Research Associate II - FSP
$91K - $137K *
Empower your career by managing clinical research sites, ensuring patient safety, and maintaining data integrity. Collaborate with teams to oversee study implementation and monitoring, while enhancing...
2 days ago
$80K - $95K *
Join us to lead a dynamic team in optimizing revenue cycle operations for multiple clients. Drive continuous improvement and ensure client satisfaction while managing performance metrics and fostering...
2 days ago
Clinical Specialist Western Canada
$80K - $111K *
Partner with us to transform patient care in advanced cochlear implant solutions. Build trusted relationships, execute strategic plans, and improve outcomes by leveraging clinical expertise and consul...
Reposted 2 days ago
Director, Clinical Development
$165K - $215K *
Empower innovation in ophthalmic device development by leading global clinical strategies for surgical programs, from feasibility to regulatory submissions. Collaborate cross-functionally to drive pro...
Reposted 2 days ago
Manager, Clinical Stewardship Operations (RN)
$150K - $165K *
Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...
2 days ago
Director Commercial Execution USA - Digital Health (Silent Cloud)
$162K - $203K *
Join a team that's transforming digital tinnitus care in the U.S. by leading commercial execution across healthcare sectors. Drive adoption and optimize partnerships to enhance patient engagement and...
Reposted 2 days ago
Senior Manager, Physical Therapy
$110K - $130K *
Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...
2 days ago
$190K - $240K *
Lead the end-to-end revenue cycle operations, driving improvements in eligibility, coding, and claims management. Collaborate with teams to enhance workflows and ensure accountability, while evaluatin...
2 days ago
$72K - $97K *
Empower individuals by coordinating personalized care plans for seniors and members with disabilities. Collaborate with healthcare providers and manage caseloads while enjoying a flexible, remote work...
2 days ago
Medical Review Nurse II - SNF/MDS Auditor
$90K - $105K *
Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...
2 days ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 2 days ago
Public Health Analyst I (Vaccines)
$100K - $108K *
Join a dynamic team to provide essential data management and help desk support for public health initiatives, ensuring effective communication and technical assistance for healthcare facilities and us...
3 days ago
Public Health Analyst I (Vaccines)
$100K - $108K *
Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...
3 days ago
$113K - $133K *
Shape global health initiatives by managing HIV programs, coordinating with stakeholders, and ensuring timely reporting. This role offers hands-on experience in public health, ideal for detail-oriente...
3 days ago
Sr. Director, Industry and Payor Strategy
$174K - $217K *
Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...
3 days ago
DRG Validation Auditor - Off Hours Work (2nd, 3rd, or weekend shift work)
$95K *
Lead the charge in auditing inpatient claims, ensuring coding accuracy and clinical validation. Utilize advanced coding expertise to analyze claims independently, while meeting productivity and qualit...
3 days ago
$80K - $95K *
Engage with patients as a Virtually Integrated Care RN, providing essential remote support and care coordination. Utilize advanced clinical skills to assess needs, develop care plans, and enhance pati...
3 days ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
Director Global Safety- Global Periodic Aggregate Safety Reports
$191K - $258K *
Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...
3 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...
Reposted 3 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Join a dynamic team as you oversee pharmacy operations, ensuring compliance and excellence in clinical care. Lead a diverse staff, manage performance, and collaborate effectively for optimal patient o...
Reposted 3 days ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.