Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$108K - $147K *

Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$113K - $155K *

Champion quality excellence by executing business programs across manufacturing sites, collaborating with cross-functional teams to enhance product standards, manage consumer insights, and drive conti...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Food & Beverages

$145K - $218K *

Transform your career by driving clinical trial success through strategic site engagement and collaboration with key opinion leaders in Neuroscience and Oncology, enhancing patient enrollment and rete...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$67K - $111K *

Lead the charge in delivering compassionate, expert behavioral health care across diverse populations, ensuring continuity and support throughout each member's wellness journey while leveraging clinic...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$73K - $91K *

Join a dedicated team of Registered Nurses committed to delivering compassionate, high-quality patient care in a fast-paced environment. Collaborate with interdisciplinary teams to enhance health outc...

Today

  •   5 - 7 years exp.  •   Healthcare

$72K - $90K *

Unlock vital support for patients as a Social Worker, applying therapeutic techniques and assessments to enhance emotional well-being in a collaborative healthcare environment. Impact lives through ps...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$76K - $93K *

Transform patient care by assisting with invasive cardiovascular procedures. Collaborate with physicians, operate advanced equipment, and ensure accurate documentation while maintaining a sterile envi...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$79K - $99K *

Shape the future of patient care by providing evaluation and treatment as an Occupational Therapist. Collaborate with a dedicated team to enhance patient independence and function, supporting a cultur...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower patient health by using your clinical expertise to oversee medication management and collaborate with healthcare professionals, ensuring optimal therapeutic outcomes across care settings for d...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$115K *

Join us in providing exceptional occupational therapy services, evaluating patients, and developing tailored treatment plans to enhance daily living skills. Collaborate with care teams to ensure compl...

Today

  •   Less than 5 years exp.  •   Staffing

$87K *

Contribute to patient recovery by delivering physical therapy services under supervision, enhancing mobility and function while adhering to safety and compliance standards. Collaborate with healthcare...

Today

  •   Less than 5 years exp.  •   Staffing

$90K - $110K *

Support patient care by managing complex cases in collaboration with healthcare teams. Utilize critical thinking and clinical skills to assess, diagnose, and treat patients in an outpatient urgent car...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Develop high-quality, scientifically accurate content for medical affairs and promotional education. Collaborate with teams to ensure clarity and compliance while translating complex data into engagin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$187K - $234K *

Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Optimize customer adoption by leading product training and engagement, ensuring successful go-live and sustained usage. Act as a trusted radiology workflow consultant, driving deep product knowledge a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$72K - $97K *

Join a dynamic team to support global clinical study delivery, ensuring quality and compliance in clinical operations. Collaborate with cross-functional teams to manage study logistics, data tracking...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$67K - $199K *

Lead NCQA Health Outcomes and Community-Focused Care Accreditation initiatives, driving quality improvement and compliance across health plans. Collaborate with teams to enhance equitable health outco...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $114K *

Engage with healthcare providers to enhance performance in HEDIS, STARS, and value-based care. Develop contracts and foster partnerships while leveraging data analytics. Travel within territory requir...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$190K - $252K *

Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $91K *

Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.