Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Occupational Therapy | Rehabilitation | Shift 5x8 Days
$115K *
Join us in providing exceptional occupational therapy services, evaluating patients, and developing tailored treatment plans to enhance daily living skills. Collaborate with care teams to ensure compl...
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PTA | Rehabilitation | Shift 5x8 Days
$87K *
Contribute to patient recovery by delivering physical therapy services under supervision, enhancing mobility and function while adhering to safety and compliance standards. Collaborate with healthcare...
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Advanced Practice Provider - Same Day, Spearfish
$90K - $110K *
Support patient care by managing complex cases in collaboration with healthcare teams. Utilize critical thinking and clinical skills to assess, diagnose, and treat patients in an outpatient urgent car...
Reposted today
Senior Site Management Associate
$80K - $95K *
Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...
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$85K - $100K *
Develop high-quality, scientifically accurate content for medical affairs and promotional education. Collaborate with teams to ensure clarity and compliance while translating complex data into engagin...
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Medical Physicist | Radiation Oncology Cancer Care Institute
$187K - $234K *
Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...
Reposted today
Certified Registered Nurse Anesthetist | Spearfish Hospital
$160K - $190K *
Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...
Reposted today
Senior Implementations Product Specialist
$110K - $130K *
Optimize customer adoption by leading product training and engagement, ensuring successful go-live and sustained usage. Act as a trusted radiology workflow consultant, driving deep product knowledge a...
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Global Study Management Associate
$72K - $97K *
Join a dynamic team to support global clinical study delivery, ensuring quality and compliance in clinical operations. Collaborate with cross-functional teams to manage study logistics, data tracking...
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$120K - $145K *
Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...
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Sr. Manager, Health Outcomes Accreditation
$67K - $199K *
Lead NCQA Health Outcomes and Community-Focused Care Accreditation initiatives, driving quality improvement and compliance across health plans. Collaborate with teams to enhance equitable health outco...
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Network Management Consultant - Provider Performance - DFW and East TX
$63K - $114K *
Engage with healthcare providers to enhance performance in HEDIS, STARS, and value-based care. Develop contracts and foster partnerships while leveraging data analytics. Travel within territory requir...
Reposted today
Certified Registered Nurse Anesthetist | Rapid City Hospital
$160K - $190K *
Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...
Reposted today
Director - Professional Coding (Remote)
$190K - $252K *
Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...
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Asset Lead Medical Director - Obesity and Related Conditions
$217K - $294K *
Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...
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$74K - $91K *
Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...
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$100K - $120K *
Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...
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Clinical Documentation Integrity Supervisor
$110K - $159K *
Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...
Reposted today
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
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$72K - $90K *
Join a team that's dedicated to delivering high-quality MRI examinations, utilizing advanced imaging techniques while ensuring patient comfort and safety. Collaborate in a professional environment foc...
Reposted today
Field Pharmacy Account Manager
$90K - $150K *
Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...
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Senior Consultant - HHS Collaboratives
$90K - $150K *
Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...
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Payment Integrity Program Development Senior Manager
$110K - $150K *
Lead the charge in optimizing payment integrity programs, ensuring effective execution and performance monitoring. Collaborate across functions to drive improvements in operational efficiency and prov...
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Director of Clinical Operations, Strategy, and Innovation
$182K - $247K *
Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...
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$61K - $104K *
Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...
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What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.