Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$115K *

Join us in providing exceptional occupational therapy services, evaluating patients, and developing tailored treatment plans to enhance daily living skills. Collaborate with care teams to ensure compl...

Today

  •   Less than 5 years exp.  •   Staffing

$87K *

Contribute to patient recovery by delivering physical therapy services under supervision, enhancing mobility and function while adhering to safety and compliance standards. Collaborate with healthcare...

Today

  •   Less than 5 years exp.  •   Staffing

$90K - $110K *

Support patient care by managing complex cases in collaboration with healthcare teams. Utilize critical thinking and clinical skills to assess, diagnose, and treat patients in an outpatient urgent car...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Develop high-quality, scientifically accurate content for medical affairs and promotional education. Collaborate with teams to ensure clarity and compliance while translating complex data into engagin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$187K - $234K *

Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Optimize customer adoption by leading product training and engagement, ensuring successful go-live and sustained usage. Act as a trusted radiology workflow consultant, driving deep product knowledge a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$72K - $97K *

Join a dynamic team to support global clinical study delivery, ensuring quality and compliance in clinical operations. Collaborate with cross-functional teams to manage study logistics, data tracking...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$67K - $199K *

Lead NCQA Health Outcomes and Community-Focused Care Accreditation initiatives, driving quality improvement and compliance across health plans. Collaborate with teams to enhance equitable health outco...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $114K *

Engage with healthcare providers to enhance performance in HEDIS, STARS, and value-based care. Develop contracts and foster partnerships while leveraging data analytics. Travel within territory requir...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$190K - $252K *

Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $91K *

Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $159K *

Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$145K - $165K *

Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$72K - $90K *

Join a team that's dedicated to delivering high-quality MRI examinations, utilizing advanced imaging techniques while ensuring patient comfort and safety. Collaborate in a professional environment foc...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Lead the charge in optimizing payment integrity programs, ensuring effective execution and performance monitoring. Collaborate across functions to drive improvements in operational efficiency and prov...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$182K - $247K *

Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$61K - $104K *

Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.