Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Healthcare Jobs in Iowa

Average Salary in USD

Average Salary: $109,865

Sort By: Relevance

$100K - $120K *

Transform healthcare delivery by leading operations for a growing telehealth practice. Collaborate with clinical teams to enhance patient care through innovative solutions and efficient workflows, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $104K *

Inspire efficient EHR system performance by leading applications analysis and optimization. Drive project management and collaboration while mentoring team members and enhancing patient care through e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $113K *

Join us to lead the Professional Coding Operations team, ensuring accurate coding practices and compliance. Collaborate with stakeholders, mentor staff, and drive improvements in coding efficiency and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$204K - $340K *

Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$69K - $125K *

Join a dynamic team to oversee quality of care investigations and improvement initiatives, ensuring compliance with regulatory standards while enhancing patient outcomes and organizational efficiency...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Innovate clinical system implementations by ensuring seamless integration of technologies and workflows. Collaborate with clinical and technical teams to enhance patient care and operational efficienc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $133K *

Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$247K - $309K *

Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive enterprise clinical performance initiatives, translating executive priorities into actionable plans. Lead cross-functional teams, establish governance structures, and ensure accountability for s...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Advance healthcare quality by implementing utilization management strategies. Analyze data for provider enhancement and member satisfaction, while promoting efficient care delivery through collaborati...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Join a team that's dedicated to delivering impactful medical communications. As a Senior Account Manager, you'll lead strategic projects for pharmaceutical clients, ensuring quality and timely executi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Champion patient care by evaluating and managing chronic pain conditions, collaborating with healthcare teams to create tailored treatment plans that enhance quality of life and optimize outcomes for...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $235K *

Unlock potential by driving scientific excellence as a strategic partner, educating healthcare professionals on Immuno-Oncology and fostering relationships that support cancer therapeutic initiatives...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$65K - $105K *

Contribute to transformative care for underserved women by analyzing assessments, providing counseling, and collaborating with healthcare professionals in a fully remote setting. Your expertise will e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Transform patient care by evaluating and managing chronic pain conditions. Collaborate with healthcare teams to create tailored treatment plans that enhance quality of life and optimize patient outcom...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$119K *

Join a dynamic team to oversee Epic applications, ensuring seamless integration and optimization across clinical services. Drive improvements in workflows and enhance patient care through effective ma...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$119K *

Join us in optimizing Epic applications to enhance clinical workflows and patient care. Lead a team of analysts, ensuring seamless integration and functionality across departments while driving contin...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$57K - $105K *

Join a team that's dedicated to providing exceptional pre and post-operative care. As a Staff Nurse, you'll assess patient needs, deliver quality nursing care, and lead a collaborative healthcare team...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Champion clinical performance management by leading cross-functional initiatives, translating executive priorities into actionable plans, and ensuring accountability across the organization to drive s...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$185K - $230K *

Shape the future of community access by developing strategies to optimize reimbursement processes, collaborating with stakeholders, and ensuring compliance with healthcare regulations while enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock your potential as a Clinical Manager, overseeing Anesthesia operations. Lead teams, manage budgets, and ensure quality patient care in a dynamic healthcare environment while fostering positive...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$210K - $250K *

Drive the translational strategy for immunology therapies, focusing on biomarker development and clinical pharmacology. Collaborate cross-functionally to advance pipeline assets and support regulatory...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $165K *

Join a team that's dedicated to enhancing clinical education and customer experience. In this role, you'll drive training strategies and support ultrasound product implementation, impacting patient ca...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.