Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Healthcare Jobs in Iowa

Average Salary in USD

Average Salary: $109,865

Sort By: Relevance

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $259K *

Lead the charge in optimizing global drug safety operations, ensuring compliance and excellence in pharmacovigilance. Drive strategic initiatives, manage vendor relationships, and enhance processes to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $149K *

Unlock potential by leading healthcare data analytics to enhance hospital quality performance and rankings. Collaborate with teams to design dashboards, mentor analysts, and present insights to execut...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$65K - $108K *

Lead the charge in ensuring coding accuracy and compliance by reviewing medical records and documentation. Utilize ICD-10 and CPT systems to uphold quality standards while responding to coder inquirie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$210K - $250K *

Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $176K *

Inspire operational excellence as a strategic leader overseeing 8-10 pharmacies. Drive compliance, enhance patient care, and develop talent while ensuring consistent performance across multiple locati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$291K *

Engage with a dynamic team as a CRNA in a floating role, providing regional anesthesia across multiple facilities. Enjoy autonomy, diverse cases, and a supportive environment with competitive compensa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$142K - $177K *

Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Lead and oversee daily operations of the Operating Room, championing patient care and staff development while fostering a collaborative environment focused on quality and safety in surgical services...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$300K - $350K *

Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $155K *

Join a team that's dedicated to enhancing clinical workflows in Radiation Oncology. As a Clinical Success Manager, you'll train clinics, solve problems, and foster relationships to ensure customer sat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Transform the landscape of emerging therapies by leading strategic clinical innovation, guiding development, and ensuring regulatory readiness for novel therapeutic solutions across early- and mid-sta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$74K - $99K *

Shape the future of regulatory submissions by ensuring high-quality QC reviews of clinical documents. Collaborate with global teams to meet project timelines while maintaining compliance with industry...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$119K - $175K *

Optimize healthcare compliance by leading regulatory assurance efforts, ensuring adherence to HIPAA, HITECH, and HITRUST standards while collaborating with clinical leadership to maintain a defensible...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$121K - $141K *

Champion patient-centered care as a Nurse Practitioner or Physician Assistant, building lasting relationships while providing comprehensive outpatient services in a supportive, collaborative environme...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$105K - $125K *

Transform coding quality and efficiency as a senior expert in radiology coding. Collaborate with cross-functional teams to enhance processes, provide guidance, and drive best practices, ensuring excep...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $287K *

Shape the future of oncology by cultivating relationships with KOLs, providing critical insights, and supporting research initiatives. Drive awareness and education while ensuring compliance and integ...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $114K *

Lead the Nursing department by planning and directing operations to ensure exceptional care, fostering a supportive environment, and guiding clinical practices while meeting regulatory standards and c...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $96K *

Support nursing leadership by overseeing MDS processes, ensuring compliance, and enhancing clinical practices. Collaborate with healthcare teams to deliver high-quality care and maintain accurate medi...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K - $250K *

Empower oncology research by leveraging real-world evidence and clinical expertise. Collaborate with cross-functional teams to develop innovative solutions that enhance cancer treatment and support bi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $255K *

Shape the future of cancer treatment by leading Field Medical Excellence initiatives. Drive operational improvements, strategic planning, and cross-functional collaboration to enhance the impact of ou...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Manage comprehensive evaluations and treatment plans for chronic pain patients, collaborating with healthcare teams to enhance patient outcomes and quality of life through evidence-based practices and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $250K *

Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.