Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Virtual Oncology Nurse Navigator
$85K - $100K *
Support the oncology care journey by delivering high-quality virtual patient care, coordinating services, and providing clinical support while building strong relationships with patients and clinical...
Reposted today
$120K - $140K *
Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...
2 weeks ago
Senior Customer Succes Manager
$110K - $130K *
Pioneer customer success by nurturing strategic relationships, driving product adoption, and ensuring satisfaction. Leverage your expertise to mentor junior team members and shape customer success str...
4 weeks ago
$80K - $95K *
Unlock potential by supporting SAP system readiness for new data center launches. Collaborate with cross-functional teams to ensure accurate inventory tracking, troubleshoot system issues, and train e...
2 weeks ago
Dashboard Developer (Medicare/Medicaid)
$72K - $97K *
Drive impactful data visualization by designing and maintaining interactive dashboards. Collaborate with analysts to convert complex data into actionable insights, enhancing decision-making for Medica...
1 week ago
Nurse Practitioner (NP) - Kansas City, MO
$100K - $120K *
Transform your career with a flexible Nurse Practitioner role focused on wound care. Collaborate with expert physicians, utilize advanced technologies, and prioritize patient care in a supportive envi...
3 weeks ago
Senior Director - BDM - Life Insurance & Annuities
$170K - $200K *
Join us to drive client relationships and business growth, managing complex accounts while ensuring delivery excellence. Collaborate with stakeholders to create strategic account plans and lead new bu...
1 week ago
Enterprise Integration Architect
$110K - $130K *
Contribute to the design and governance of enterprise integration solutions, ensuring seamless connectivity across applications and data services. Lead strategic initiatives, evaluate technologies, an...
3 weeks ago
Portfolio Consultant- Private Wealth
$95K - $115K *
Empower high-net-worth clients by delivering tailored investment strategies and consultative support. Collaborate with financial advisors to enhance portfolio management and drive personalized wealth...
3 weeks ago
Manager, Endpoint Security Engineering
$102K - $190K *
Pioneer the future of endpoint security by leading a dynamic engineering team, ensuring operational excellence, and driving innovative capabilities to protect enterprise assets while aligning with bus...
1 week ago
$120K - $145K *
Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...
Today
Program Manager, Implementation (Launch)
$100K - $120K *
Transform healthcare delivery by leading program initiatives that drive partner success in value-based care. Utilize data-driven strategies to manage launch processes, ensuring alignment across teams...
2 weeks ago
Senior Sales Engineer, Data Products
$125K - $160K *
Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...
1 week ago
Senior Business Development Manager, Health Systems and PACE
$125K - $150K *
Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...
1 week ago
Lead Bioinformatics Scientist (Oncology)
$130K - $163K *
Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...
5 days ago
$86K - $112K *
Deliver innovative Salesforce solutions by leading design, development, and integration efforts. Collaborate with cross-functional teams to enhance operational efficiency and drive business value thro...
4 weeks ago
Senior Director, Specialty Network Development
$139K - $176K *
Unlock potential by leading the strategy and growth of specialty healthcare networks. Drive multi-year vision, manage complex programs, and cultivate strategic relationships to enhance access and savi...
3 weeks ago
Account Executive, Midwest ECM
$80K - $95K *
Unlock potential by driving growth in our Enterprise Content Management business. Engage with diverse stakeholders, navigate complex sales cycles, and expand client relationships across the Midwest wh...
1 week ago
$225K - $275K *
Lead the Consultant Relations strategy by fostering deep relationships with major consulting firms, ensuring proactive engagement in live deals, and driving business growth through effective account m...
3 weeks ago
Director Service Coordination and Long-Term Services and Supports, Geisinger Health Plan
$110K - $130K *
Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...
1 week ago
$72K - $90K *
Help us provide compassionate, skilled nursing care in patients' homes, guiding their care plans and ensuring dignity and support throughout their healthcare journey. Join a team that values quality a...
1 week ago
Senior Analyst, Marketing Strategy & Operations
$111K - $167K *
Drive impactful marketing strategies by leveraging data analysis and AI tools. Collaborate cross-functionally to enhance funnel performance, ROI modeling, and operational efficiency, ensuring alignmen...
4 days ago
Senior Account Manager, Med Affairs
$90K - $105K *
Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...
Reposted 2 weeks ago
Associate Director, Global Value & Access, Hematology
$153K - $203K *
Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...
3 weeks ago
Software Engineer II - Java, Spring, AWS, CI/CD
$121K - $191K *
Join the team to design and develop scalable software solutions for healthcare supply chain transactions. Collaborate with cross-functional partners to enhance the rules engine and deliver high-qualit...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.