Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$130K - $145K *
Champion data privacy across jurisdictions by providing expert advice, managing compliance, and supporting initiatives within a global team. Collaborate with colleagues to ensure lawful handling of pe...
5 days ago
Associate Medical Director (RadScience)
$110K - $130K *
Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...
2 weeks ago
Clinical Trial Liaison (Oncology)
$100K - $120K *
Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...
1 week ago
Director of Clinical Reimbursement, Skilled Nursing
$125K - $150K *
Champion the integration of clinical reimbursement expertise into product development, ensuring compliance and accuracy in skilled nursing assessments. Collaborate with teams to enhance client outcome...
Today
UM Operations Strategy Implementation Lead
$83K - $132K *
Champion operational excellence by leading compliance and process improvements in Utilization Management. Collaborate across teams to identify gaps, drive change, and ensure adherence to regulatory st...
4 days ago
Licensed Therapist (LCSW, LPC, LMFT)
$80K - $101K *
Transform your career with a role that offers flexible schedules, competitive pay, and a supportive team environment. Enjoy 100% outpatient care with hybrid options, focusing on patient excellence and...
Yesterday
Licensed Therapist (LCSW, LPC, LMFT)
$80K - $101K *
Elevate patient care by providing expert therapy services in a flexible, supportive environment. Enjoy autonomy over your schedule while collaborating with a dedicated team to enhance mental health ou...
Yesterday
Senior Director, Fair Lending Solutions
$160K - $190K *
Join us in shaping the future of Fair Lending solutions. Drive product strategy, deliver expert analysis, and enhance client outcomes while navigating complex regulatory landscapes. Your expertise wil...
6 days ago
Nurse Practitioner or Physician Assistant - F/T or P/T - Phoenix FM - Washington MO
$90K - $110K *
Collaborate to deliver exceptional primary care in a supportive environment. Engage with patients through comprehensive evaluations and treatment plans while emphasizing wellness. Enjoy flexible sched...
Reposted 2 days ago
Healthcare Senior Project Manager- Construction
$110K - $130K *
Optimize project delivery in healthcare construction by leading teams, managing risks, and ensuring compliance with regulatory standards. Drive client relationships and mentor junior staff while achie...
Reposted 4 days ago
Senior / Global Regulatory Labeling Strategist
$125K - $150K *
Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...
2 weeks ago
Quarterly Planning and Operations Analyst
$75K - $90K *
Drive execution and optimization of analytics strategies, collaborating with diverse teams to enhance product development and operational performance using AI and data insights. Be a key partner in co...
Reposted 1 week ago
Senior Insider Threat Investigator
$80K - $165K *
Elevate insider threat investigation capabilities by leveraging advanced analytics and risk assessment skills to support complex investigations and enhance organizational security posture against insi...
1 week ago
Senior Business Systems Analyst
$107K - $180K *
Lead the resolution of complex integration issues, collaborating with cross-functional teams to enhance reliability and support. Develop documentation and tools that empower partners and improve opera...
2 weeks ago
Auditor Technical Trainer (Outpatient/Specialty Audits)
$107K - $119K *
Advance the effectiveness of clinical audit teams by designing and delivering targeted training programs. Collaborate with experts to enhance workflows and improve audit productivity, ensuring high st...
2 days ago
$80K - $95K *
Join a team that's dedicated to managing chronic conditions through telephonic care. Utilize your clinical expertise to assess, develop, and implement personalized care plans while collaborating with...
Today
Manager, Predictive Modeling and Machine Learning
$158K - $170K *
Lead the development of predictive models integrating advanced ML techniques to drive strategic decision-making across credit risk, collections, and business operations while mentoring data scientists...
Reposted 4 weeks ago
$125K - $150K *
Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...
2 weeks ago
Enterprise Account Executive, Apromore
$141K - $214K *
Engage with enterprise clients to drive Agentic AI adoption, leveraging your expertise in process intelligence to deliver bespoke B2B solutions that enhance operational efficiency and foster lasting r...
Reposted 2 weeks ago
Senior Site Management Associate
$80K - $95K *
Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...
5 days ago
Associate Director, Innovation Strategy and Execution
$110K - $130K *
Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...
1 week ago
$100K - $140K *
Discover your potential as you design and develop impactful web experiences, collaborating across teams to create engaging landing pages and brand sites that drive conversions and enhance user interac...
5 days ago
$120K - $145K *
Empower clinical trial design by architecting robust data infrastructures that streamline insights extraction from diverse clinical documents, enhancing decision-making through advanced data pipelines...
1 week ago
Director, Operations Readiness
$117K - $176K *
Drive the development and governance of enterprise processes, ensuring alignment across operations and technology. Lead initiatives that enhance operational excellence and foster adoption of standardi...
Today
Senior Cyber Security Consultant
$110K - $130K *
Shape the future of cybersecurity in higher education by delivering expert assessments, advisory services, and tailored remediation plans that empower institutions to enhance their security posture an...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.