Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$72K - $99K *
Engage in life-saving patient care as a Registered Nurse in outpatient dialysis. Collaborate with a dedicated team, monitor treatment plans, and educate patients on kidney health. Flexible shifts and...
Yesterday
$87K - $122K *
Join a dedicated outpatient dialysis team to provide compassionate care for patients with kidney conditions. Collaborate with clinical staff, educate families, and manage treatment plans in a fast-pac...
1 week ago
$91K - $124K *
Join a team that's dedicated to delivering compassionate dialysis care. In this role, you'll monitor patient health, educate individuals, and collaborate with a skilled team in a fast-paced outpatient...
1 week ago
$83K - $114K *
Champion patient care by delivering dialysis treatments and monitoring health in a collaborative outpatient setting. Utilize critical thinking and strong communication skills to ensure safety and comf...
Reposted 2 weeks ago
$87K - $118K *
Contribute to exceptional patient care by delivering dialysis treatments, monitoring patient status, and collaborating with a dedicated clinical team in a fast-paced outpatient environment. Utilize cr...
Reposted 3 weeks ago
YM New Provider Auditor and Educator
$82K - $131K *
Join a team that's dedicated to enhancing compliance programs and policies. In this role, you'll monitor regulatory activities, conduct audits, and collaborate with leaders to ensure adherence to comp...
4 days ago
Implementation Manager, Financial Services
$100K - $120K *
Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...
6 days ago
$95K - $115K *
Champion the delivery of IT projects by leading teams, managing risks, and ensuring alignment with business goals. Collaborate with stakeholders to drive innovation and optimize resources for successf...
6 days ago
$120K - $145K *
Unlock AI-driven engineering transformation by collaborating with clients to enhance SDLC processes. Drive measurable improvements in delivery speed and quality through innovative solutions and hands...
2 weeks ago
Principal Product Manager, Member Experience
$200K - $230K *
Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...
2 weeks ago
$71K - $125K *
Transform client relationships by supporting sales and credit functions, managing lending processes under $10M, and ensuring data integrity. Collaborate with teams to create impactful pitch materials...
Yesterday
Associate Director, Advisor Relations
$145K - $175K *
Champion EPAM's growth by leading Advisor Relations strategy across North America. Build trusted relationships with sourcing advisors to drive commercial opportunities and enhance market perception, a...
6 days ago
Human Resource Business Partner
$58K - $110K *
Transform the employee experience by aligning HR strategies with business goals. As a key HR Business Partner, you'll drive engagement, performance excellence, and support a diverse workforce in a dyn...
6 days ago
$95K - $115K *
Elevate project outcomes by managing complex initiatives, leading teams, and ensuring stakeholder alignment. Drive quality improvement and change management while fostering collaboration to achieve st...
Today
$80K - $95K *
Champion comprehensive pediatric nephrology care by collaborating with an interdisciplinary team to manage chronic and acute renal conditions, ensuring high-quality support throughout the patient care...
2 weeks ago
$120K - $140K *
Lead the charge in transforming legacy data into streamlined, AI-driven migrations. Own end-to-end processes, automate validation, and enhance efficiency while ensuring data integrity and accuracy for...
Today
Clinical Development Medical Director, Obesity/Cardiovascular
$274K - $371K *
Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...
Reposted 2 weeks ago
Program Manager - Federal Financial / Regulatory Service
$105K - $150K *
Inspire impactful change by leading complex federal digital services programs. Oversee strategy, execution, and customer relationships while managing multidisciplinary teams to deliver high-quality te...
Reposted 1 week ago
Director - IT Planning & Performance Management
$129K - $215K *
Transform enterprise IT planning and performance management, aligning technology priorities and investments to drive informed executive decisions and enhance organizational effectiveness across multip...
5 days ago
$75K - $158K *
Champion operational excellence by managing the Avantra platform for SAP, ensuring secure, efficient monitoring and automation across diverse environments while collaborating with cross-functional tea...
Reposted 2 weeks ago
Program Administration Director
$130K - $216K *
Transform program administration for a large federal services initiative, overseeing workforce planning, financial operations, and compliance. Collaborate with diverse teams to enhance operational eff...
2 weeks ago
Registered Nurse (Renal Nurse Manager)
$80K - $95K *
Empower healthcare excellence by leading a dedicated nursing team, ensuring high-quality patient care, and fostering professional development in a dynamic clinic environment. Drive initiatives that en...
4 days ago
$95K - $115K *
Empower our finance team by overseeing accounting operations, ensuring compliance, and enhancing financial reporting. Lead month-end close activities and mentor team members in a dynamic, multi-entity...
1 week ago
Solutions Engineer, API Integration
$107K - $180K *
Join a team that's redefining API integration! Leverage your technical expertise to guide partners through the integration lifecycle, ensuring seamless onboarding and successful implementations while...
1 month ago
Senior Clinical Research Associate/Clinical Research Associate II - US Any Region - FSP
$95K - $115K *
Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.