Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
People Systems and Solutions Manager
$188K - $235K *
Unlock potential by shaping and driving the People Systems roadmap, translating business needs into scalable processes, and managing technology vendors to enhance the employee lifecycle through innova...
3 weeks ago
Non-Human Identity Solution Architect
$120K - $145K *
Shape the future of non-human identity management by designing secure, scalable solutions that integrate with enterprise platforms, ensuring compliance and minimizing risk while collaborating with cro...
Reposted today
Revenue Cycle Business Partner II
$78K - $113K *
Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...
1 week ago
$80K - $95K *
Transform the admissions process by leading a dedicated team, implementing strategic initiatives, and ensuring quality management in a dynamic healthcare environment focused on mental health services...
1 week ago
Senior Consultant - Grants Lifecyle Process Improvement
$98K - $163K *
Optimize federal grants management operations by assessing processes, identifying inefficiencies, and delivering actionable recommendations. Collaborate with stakeholders to enhance program outcomes a...
3 weeks ago
Quality & Commissioning Manager
$95K - $115K *
Reimagine quality assurance in electrical construction by leading project teams to ensure compliance with standards, enhance performance, and deliver excellence in service. Collaborate effectively wit...
Reposted 2 weeks ago
Senior Manager, Solutions Consulting
$230K - $280K *
Lead a high-performing team to enhance Solutions Consulting, drive cross-functional collaboration and ensure the success of strategic accounts through innovative, accountable deal execution and contin...
Reposted 3 weeks ago
EHRM Operations Support Analyst (Remote Opportunity)
$80K - $95K *
Join a supportive team to enhance healthcare operations through HL7 interface monitoring, troubleshooting integration issues, and assisting with deployments in a remote environment, while ensuring sys...
Reposted 4 days ago
Director, Advanced Analytics and Modeling - Key Drivers & Actions (KDA)
$194K - $361K *
Reimagine your career by leading advanced analytics initiatives that drive enterprise performance. Collaborate across functions to translate insights into strategic actions, enhancing growth and marke...
4 days ago
$110K - $130K *
Lead the charge in enhancing our business continuity and resilience program. Collaborate with teams to identify recovery priorities, assess risks, and implement actionable solutions that ensure operat...
3 weeks ago
$100K - $120K *
Join a dynamic team that delivers quality pharmaceutical care by managing medication orders, inventory, and technician oversight to ensure compliance and patient satisfaction while demonstrating exper...
Reposted yesterday
Founding Enterprise Account Executive, Health Plans
$270K - $340K *
Unlock potential by driving sales for innovative healthcare compliance solutions. Own the full sales cycle with health plans, transforming initial conversations into lasting partnerships while shaping...
Today
$105K - $177K *
Join a dynamic team as a Senior Price-to-Win Analyst, leveraging your analytical skills to drive strategic pricing recommendations and enhance competitive positioning in high-stakes federal pursuits...
Today
$150K - $180K *
Build and lead a scalable U.S. service organization for battery energy storage systems, ensuring customer satisfaction and operational excellence throughout the post-sale lifecycle, from commissioning...
4 weeks ago
Sr Epic Bridges Integration Engineer
$110K - $130K *
Champion seamless data integration across IT systems by leading complex projects, troubleshooting issues, and optimizing performance. Leverage your expertise in integration technologies to ensure data...
1 month ago
Sr. Clinical Project Research Manager - Oncology Phase 3 Study
$110K - $130K *
Deliver impactful project leadership by guiding cross-functional teams through all phases of clinical research, ensuring compliance, effective communication, and timely project milestones that enhance...
Reposted yesterday
NP or PA for Pulm/Sleep Medicine (Springfield and Branson)
$90K - $110K *
Deliver advanced nursing care by collaborating with physicians to enhance patient outcomes, manage cases, and evaluate performance. Engage in physical examinations, diagnostic testing, and treatment p...
2 weeks ago
$71K - $106K *
Lead the charge in delivering exceptional patient care as a Charge Nurse in a high-acuity Emergency Services department, ensuring safety, quality, and effective communication among healthcare teams wh...
Reposted 1 week ago
Product Expansion Lead at AIOS - Remote, $200k-$400k/yr + 0.15%-0.50% equity
$200K - $400K *
Champion product expansion by launching and scaling non-GLP-1 offerings. Drive growth strategies, analyze market opportunities, and collaborate across teams to ensure successful product launches and r...
Yesterday
$80K - $95K *
Lead advanced troubleshooting and repair of medical equipment, ensuring customer satisfaction through service excellence. Collaborate with teams, mentor junior engineers, and drive initiatives to enha...
3 weeks ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
3 weeks ago
$98K - $163K *
Join a team that's dedicated to enhancing fraud risk assessments for digital services. You'll evaluate risks, identify fraud controls, and support ongoing assessments, ensuring timely delivery and eff...
Today
Staff Attorney - St. Louis Metro Region
$74K - $90K *
Join a team that's dedicated to advancing child welfare through active litigation. As a Staff Attorney, you'll provide legal counsel, manage diverse cases, and advocate for families in juvenile court...
6 days ago
$90K *
Transform the efficiency of distribution operations by optimizing processes, implementing continuous improvement initiatives, and leveraging advanced technologies to enhance productivity and service l...
Reposted today
Manager of Utilization Management
$108K - $147K *
Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.