Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Engineering, Data Products
$223K - $290K *
Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...
Reposted yesterday
$150K - $251K *
Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...
2 weeks ago
$170K - $200K *
Elevate patient care by joining a collaborative anesthesia team, providing outpatient anesthesia services with high autonomy and flexible scheduling, while enjoying competitive pay and a supportive wo...
Today
SENIOR TECHNOLOGY CONTROLS AND COMPLIANCE ANALYST- REMOTE
$115K - $130K *
Join a team that's committed to enhancing regulatory compliance through strategic initiatives, robust IT control design, and effective collaboration across business units to ensure adherence to indust...
Reposted 6 days ago
Clinical Trials Medical Writer
$77K - $92K *
Join a dynamic team as a Medical Writer, where you'll interpret complex clinical protocols and create essential documentation for clinical studies, ensuring high-quality standards and regulatory compl...
2 weeks ago
$118K - $132K *
Drive customer success by managing partnerships and optimizing solutions for enterprise clients. Leverage your consulting expertise to engage C-level executives and enhance value in the healthcare sec...
3 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- Midwest
$76K - $114K *
Shape the future of healthcare by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and ensure...
3 weeks ago
$91K - $118K *
Lead the development and enhancement of critical software applications, ensuring performance and stability while collaborating with cross-functional teams to deliver market-driven solutions and suppor...
2 days ago
$100K - $120K *
Join a team that's dedicated to enhancing data integrity and governance. In this role, you'll manage data stewardship for investor profiles, ensuring compliance and quality across multiple domains whi...
2 weeks ago
Senior Financial Analyst (Operations)
$66K - $105K *
Help us optimize financial performance through advanced analysis and modeling. Collaborate with business leaders on budgeting, forecasting, and strategic initiatives, providing insights to drive reven...
Reposted 1 week ago
Enterprise Account Executive, Georgia
$300K - $350K *
Drive sales growth in the cybersecurity sector by acquiring new accounts, building relationships, and ensuring customer satisfaction. Leverage your expertise to exceed quotas and manage Channel Partne...
5 days ago
$272K - $408K *
Unlock enterprise growth by leading innovation strategies, managing a diverse portfolio, and fostering partnerships to create scalable business opportunities that drive long-term value and address eme...
2 weeks ago
Regulatory Affairs Consultant - Regulatory Generalist
$100K - $120K *
Take ownership of regulatory support for pharmaceutical programs, managing IND and NDA submissions, health authority interactions, and lifecycle maintenance. Collaborate with cross-functional teams to...
3 weeks ago
Client Success Manager - Law Firms
$85K - $95K *
Lead the charge in client engagement and lifecycle management, driving retention and organic growth within legal accounts. Build relationships, identify cross-sell opportunities, and ensure high clien...
2 weeks ago
Healthcare Marketing Strategy Manager
$163K - $322K *
Transform health care marketing through strategy consulting, leading teams to enhance client engagements and optimize performance across the CMO's agenda, driving measurable results in a dynamic envir...
Reposted today
Senior Manager, Health Plan Operations
$110K - $150K *
Champion operational excellence by leading Payment Integrity initiatives, ensuring accurate claims processing, optimizing workflows, and driving cross-functional collaboration to enhance performance a...
Today
Sr Director Analyst, Data Management for AI Enablement
$172K - $202K *
Champion innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients globally. Engage with stakeholders to deliver actionable advice and elevate...
1 week ago
ADON/Nurse 8:30a-5p with On-Call (Full-Time)
$86K - $87K *
Transform the care experience by leading a dedicated team, managing personalized care plans, and ensuring compliance with regulations while fostering a supportive community culture for residents and f...
3 weeks ago
ADON/Nurse 8:30a-5p with On-Call (Full-Time)
$86K - $87K *
Advance your career by coordinating exceptional care for residents, fostering a supportive community culture, and ensuring compliance with care standards while collaborating with families and staff to...
3 weeks ago
Analyst I, Falcon Complete GovCloud (Hybrid, St. Louis)
$85K - $120K *
Drive global security initiatives by leveraging hands-on technical skills in incident response and threat analysis. Collaborate with like-minded professionals to protect organizations from advanced cy...
Reposted 2 weeks ago
Director of Psychiatric Clinical Operations
$175K - $210K *
Champion operational excellence in psychiatric care by leading a dynamic team focused on quality, compliance, and innovation. Drive improvements in provider operations and enhance mental healthcare de...
4 days ago
Lead Solutions Architect - HR Technology & AI
$106K - $284K *
Transform your career by leading the design and development of innovative HR Technology solutions. Drive architectural vision and collaborate with stakeholders to ensure alignment with business object...
Yesterday
$80K - $95K *
Champion integrated psychological services for transplant patients, conducting evaluations and delivering therapy across inpatient and outpatient settings. Collaborate with multidisciplinary teams to...
5 days ago
$100K - $160K *
Lead the charge in driving security business growth by identifying opportunities, engaging prospects, and leveraging expertise to close deals. Collaborate with sales teams to enhance customer adoption...
Today
$88K - $154K *
Lead the charge in enhancing safety and quality standards; administer the Risk Program and conduct audits, assessments, and training. Collaborate with various stakeholders to ensure compliance and imp...
Reposted 4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.