Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$105K - $135K *
Partner with us to lead comprehensive RFP and proposal processes, crafting persuasive technical content and collaborating with cross-functional teams to enhance our credibility in the healthcare secto...
1 week ago
Director, Patient Financial Services (PFS) - Healthcare CBO
$106K - $176K *
Join a team that's transforming healthcare finance by leading patient financial services operations. Drive revenue cycle improvements, manage billing processes, and enhance compliance while fostering...
1 week ago
$120K - $145K *
Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...
1 week ago
Director, Patient Intelligence Strategy & Governance
$185K - $344K *
Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...
1 week ago
Principal, Exposure Analysis & Coordination
$96K - $207K *
Lead the charge in enhancing cybersecurity response capabilities by managing urgent exposure assessments and coordinating enterprise-wide efforts against emerging threats, ensuring alignment with risk...
3 weeks ago
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
1 week ago
$80K - $95K *
Join a dynamic Infrastructure team to design, implement, and manage secure, reliable networks. Enhance connectivity and performance across local and wide area networks while troubleshooting and optimi...
1 week ago
$120K - $145K *
Join a team that's dedicated to enhancing client operations and driving revenue cycle success. Lead initiatives, foster relationships, and ensure performance excellence while collaborating with stakeh...
Today
NP or PA for Primary Care Cassville
$85K - $100K *
Partner with us to deliver exceptional patient care as you collaborate with physicians, manage cases, and provide advanced nursing services, including examinations, diagnostics, and treatment plans in...
6 days ago
Senior Principal Consultant, Medicaid Programs
$158K - $185K *
Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...
1 week ago
$93K - $120K *
Join a dynamic team as you manage clinical data throughout study lifecycles, ensuring compliance and quality. Collaborate with cross-functional teams to drive data strategy and support innovative solu...
3 weeks ago
Senior Project Engineer - Healthcare Construction
$80K - $95K *
Unlock your potential as a Senior Project Engineer, managing healthcare construction projects that enhance patient care. Collaborate with diverse teams, ensure quality and safety, and drive project su...
Reposted 1 week ago
Compensation Analyst II (Programs & Partnerships)
$101K - $165K *
Deliver impactful compensation programs by leading project management, conducting analyses, and collaborating with cross-functional teams to enhance employee rewards and drive organizational success...
4 days ago
Account Executive, Audit Manager
$100K - $170K *
Champion the growth of Audit Manager by driving sales in the healthcare sector. Leverage your expertise in medical billing and coding to engage revenue cycle leaders, manage the sales pipeline, and de...
1 week ago
$155K - $185K *
Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...
6 days ago
$155K - $160K *
Shape the future of data solutions by designing scalable architectures that drive AI and analytics initiatives. Collaborate with cross-functional teams to implement innovative strategies that enhance...
1 week ago
Manager, Reputation and Consumer Insights
$120K - $150K *
Drive reputation management and consumer insights initiatives, enhancing brand trust and informing strategic decisions. Collaborate across teams to analyze data, identify trends, and improve consumer...
3 weeks ago
Nurse Navigator - South Providence Pediatrics
$75K - $109K *
Champion coordinated care across disease processes, ensuring timely access and quality management. Serve as a resource for patients and healthcare teams, driving best practices and improving outcomes...
5 days ago
Senior Manager, Microsoft Technology Account Lead, Healthcare
$135K - $160K *
Join a team that's driving strategic growth by managing key client relationships, leading Microsoft-focused initiatives, and delivering tailored solutions that enhance business value across multiple a...
Reposted today
Hospice Director of Clinical Services - RN
$80K - $95K *
Join a compassionate team as you lead quality care in hospice services, ensuring patient-centered approaches and regulatory compliance while fostering interdisciplinary collaboration and professional...
Reposted 4 days ago
Associate Director, Clinical Science
$172K - $215K *
Drive clinical development strategies for early cancer detection, overseeing rigorous study design and execution. Collaborate with stakeholders to ensure high-quality data delivery that impacts patien...
Yesterday
Medical Strategy Associate Director
$191K - $238K *
Shape the future of oncology by leading medical strategy for prostate cancer projects. Collaborate with cross-functional teams to drive scientific communication and strategic initiatives, ensuring ali...
6 days ago
$95K - $115K *
Join a team that's dedicated to optimizing software systems and applications. Leverage your expertise in application administration to enhance performance, ensure security, and support users across mu...
2 weeks ago
$125K - $150K *
Drive enterprise growth by strategically engaging high-value accounts, orchestrating complex sales processes, and leveraging AI capabilities to enhance compliance workflows. Build executive relationsh...
6 days ago
$100K - $122K *
Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.