Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Lead Business Strategy Analyst - Underwriting Measurement Strategist
$127K - $243K *
Elevate our underwriting strategy by leveraging data analytics to drive decision-making. Collaborate with cross-functional teams to develop metrics that enhance operational efficiency and optimize per...
6 days ago
$160K - $190K *
Empower your career by partnering with the Science Leadership Team to drive strategic initiatives, enhance operational effectiveness, and translate scientific vision into impactful outcomes across div...
2 weeks ago
Radiation Oncologist - Missouri Cancer Associates Osage Beach
$300K - $350K *
Join a team that's dedicated to providing exceptional cancer care while enjoying a vibrant lifestyle in a premier resort destination. Collaborate with a skilled group of oncologists and contribute to...
Yesterday
Associate Director, Industry Technology Strategist - Enterprise
$201K - $239K *
Lead the charge in driving high-value sales pursuits, orchestrating teams and resources to shape winning strategies. Influence market offerings and account growth while championing excellence in clien...
3 weeks ago
$110K - $130K *
Join a dynamic team as a Dynatrace Administrator, optimizing environments and automating incident responses. Leverage your expertise to enhance performance monitoring and ensure seamless integration w...
1 week ago
$90K - $110K *
Drive growth in digital therapeutics by engaging medical practices, guiding them from initial interest to consistent orders. Collaborate with sales and clinical teams to shape the onboarding process a...
1 week ago
Senior Security Analyst – Cloud Security
$95K - $120K *
Transform cloud security operations by enhancing AWS and Azure environments. Lead initiatives to secure cloud-native capabilities, manage incident responses, and collaborate with engineering teams to...
3 weeks ago
Configuration Lead, Compensation
$117K - $161K *
Drive your career with this strategic role, leading Workday Compensation solutions. Collaborate with cross-functional teams to optimize compensation processes, ensuring alignment with business goals a...
5 days ago
Senior Business Analyst (MMIS Finance)
$85K - $111K *
Unlock your potential by leading business and functional requirements for Medicaid financial management. Collaborate with diverse teams to enhance payment operations and ensure compliance while drivin...
1 month ago
Senior Clinical Database Programmer - eCOA
$110K - $140K *
Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...
6 days ago
Senior ML Data Scientist - Women's Health
$172K - $203K *
Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...
2 weeks ago
$170K - $195K *
Engage in strategic account acquisition for our Legal Technologies sector, focusing on sourcing, qualifying, and closing new enterprise accounts. Drive revenue growth through complex sales cycles whil...
2 weeks ago
$130K - $150K *
Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...
2 weeks ago
$95K - $115K *
Lead compliance excellence by conducting quality reviews, enhancing processes, and providing expert guidance to ensure timely, accurate client service and adherence to regulatory standards in a dynami...
2 weeks ago
Account Executive, Enterprise Suite - Financial Services
$124K - $171K *
Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...
Reposted 1 week ago
$110K - $130K *
Champion client success by managing key relationships and driving strategic initiatives. Lead cross-functional teams to deliver high-quality work while ensuring financial performance and growth for as...
Reposted 1 week ago
$175K - $210K *
Accelerate progress at joint ventures with health systems, leading complex transactions from engagement to execution. Drive growth through partnerships, leveraging strategic relationships and operatio...
Today
$110K - $130K *
Shape the future of revenue operations by building analytical frameworks that connect business goals to actionable plans. Collaborate with cross-functional teams to drive strategic decisions and optim...
Yesterday
IT Administrator, Business Applications
$115K - $151K *
Administer and enhance collaboration platforms, ensuring seamless integration and automation across teams. Collaborate with cross-functional departments to optimize workflows and improve operational e...
1 week ago
Senior Scientist - Analytical Chemist
$88K - $105K *
Empower innovation in analytical chemistry by developing LC-MS methods, mentoring junior scientists, and enhancing lab operations. Drive project success through method validation and troubleshooting i...
4 days ago
Senior Specialist, Federal Data Engineer
$110K - $130K *
Drive innovation by developing scalable data pipelines and analytics solutions. Collaborate with teams to translate complex business problems into actionable insights across diverse domains, ensuring...
2 weeks ago
RCM Implementation Consultant - EHR/SaaS/Healthcare IT/PT
$80K - $95K *
Manage the implementation process for clients in Revenue Cycle Management, ensuring efficient setup and optimization of billing workflows. Serve as the primary expert, guiding healthcare organizations...
1 week ago
Senior Cost Estimator, Enterprise Project Management
$148K - $160K *
Partner with us to drive effective cost management for global construction projects. Leverage your expertise to support project managers, optimize budgets, and mitigate risks, ensuring successful proj...
3 weeks ago
Sr. Manager, Central Monitoring, Data Analysis
$120K - $145K *
Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...
1 week ago
$104K - $174K *
Unlock your potential by developing and implementing advanced analytics and AI solutions. Collaborate with cross-functional teams to translate complex data into actionable insights, driving business a...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.