Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$100K - $120K *
Drive comprehensive health assessments by traveling to patients' homes, ensuring accurate documentation and patient education. Collaborate with healthcare teams to enhance care continuity while managi...
2 weeks ago
Vice President, Revenue Operations
$150K - $175K *
Transform revenue operations by leading systems, data, and processes that unify Sales, Marketing, and Customer Success into a streamlined revenue engine, driving growth and efficiency across the organ...
3 weeks ago
Regional Vice President, Health Plan Growth
$180K - $215K *
Empower strategic growth by managing health plan partnerships, driving revenue, and enhancing client relationships. Utilize your expertise in managed care to deliver impactful solutions and ensure cli...
4 weeks ago
Senior Project Management (Rare/Renal)
$128K - $254K *
Oversee and manage large-scale, multi-national projects, ensuring successful delivery through direct team leadership and cross-functional collaboration, while maintaining high quality and financial pe...
Reposted 1 week ago
Clinical Research Associate/Sr. Clinical Research Associate - Western US - FSP
$85K - $100K *
Optimize clinical trial execution by managing site relationships, ensuring compliance, and safeguarding patient safety. Play a key role in monitoring, training, and resolving issues to enhance study q...
Today
Business Excellence Program Manager
$101K - $152K *
Join a team that's driving organizational change and fostering continuous improvement. As a key player, you'll enhance operational efficiency and implement strategic initiatives across departments, en...
Yesterday
Associate / Analyst, Strategic Initiatives
$90K - $120K *
Advance strategic initiatives by collaborating across teams to launch innovative data tools and insurance programs. Drive project management efforts and contribute to executive presentations that shap...
6 days ago
Lead Actuarial Predictive Modeler
$110K - $130K *
Optimize predictive modeling initiatives by designing and implementing advanced actuarial pricing models. Collaborate with cross-functional teams to ensure compliance and drive strategic pricing solut...
1 week ago
Data and Analytics Integration Specialist II
$80K - $95K *
Unlock the potential of data by designing integrations and analytics solutions that empower businesses to make informed decisions. Collaborate with clients and leverage modern technologies to transfor...
2 weeks ago
Sr. Account Manager - Health Plans
$180K - $205K *
Champion client success by managing strategic accounts, driving growth, and enhancing relationships with health plans. Collaborate cross-functionally to deliver tailored solutions and ensure seamless...
2 weeks ago
Procurement Operations Analyst
$115K - $150K *
Elevate procurement operations by managing vendor coordination, documentation, and process consistency. This role focuses on execution and queue management, ensuring timely and organized procurement s...
1 week ago
Senior Director, Head of Analytical Development
$250K - $275K *
Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...
3 weeks ago
Lead Product Manager, Channels
$126K - $173K *
Shape the future of enterprise decisioning by leading cross-functional product initiatives that enhance customer experiences and drive operational readiness across multiple business channels...
1 week ago
IT Info Security Analyst III - 992398 **Internal to Department Only **
$88K - $105K *
Drive risk assessments and vulnerability testing to enhance application security. Collaborate with IT teams to implement security solutions, prepare reports, and ensure compliance with regulations whi...
Today
$87K - $108K *
Elevate your career with a rewarding role in speech therapy, providing patient-centered care in a supportive environment. Join a dedicated team focused on making a meaningful impact in skilled nursing...
4 weeks ago
Senior Director - Payroll and HR Services
$179K - $190K *
Shape the future of payroll and HR services by leading strategic initiatives, optimizing operations, and ensuring compliance across the employee lifecycle. Drive excellence in service delivery while f...
Today
Senior Actuarial Predictive Modeler
$95K - $115K *
Drive impactful pricing strategies by developing predictive models that enhance segmentation and lifetime value. Collaborate with cross-functional teams to ensure compliance and deliver high-quality a...
1 week ago
$95K - $115K *
Unlock your potential as a Data Engineer, driving innovative data solutions and optimizing data pipelines. Collaborate with cross-functional teams to enhance data quality and support analytics initiat...
Today
Senior Manager, Performance and Quality
$67K - $182K *
Unlock your potential as you lead proposal development and client audit responses, ensuring clarity and compliance in complex healthcare contracts. Drive project management for implementations while c...
Today
Account Executive, Life Sciences & Medtech
$147K - $220K *
Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...
3 weeks ago
Senior Project Manager, Implementation
$112K - $126K *
Join a team that's driving impactful healthcare solutions by managing complex projects from initiation to stabilization. Collaborate with cross-functional teams to ensure timely delivery and high-qual...
Reposted today
$100K - $118K *
Optimize information systems integrity and compliance through comprehensive audits. Collaborate with stakeholders to ensure timely responses and effective documentation, while enhancing IT controls an...
4 days ago
Medical Director - Inpatient Review
$223K - $313K *
Join a distinguished team of physicians to enhance inpatient care quality through expert clinical reviews and utilization management, impacting patient outcomes while enjoying a structured, collaborat...
Today
Manager, People Analytics & Data Science
$128K - $252K *
Drive the evolution of people analytics by building data pipelines, dashboards, and insights that empower leaders with decision-ready information. Collaborate across teams to enhance data usability an...
2 weeks ago
Senior Risk Management Associate
$123K - $142K *
Lead the execution of Enterprise Risk Management programs, collaborating across teams to enhance risk governance and training initiatives. Drive project management efforts, ensuring timely delivery an...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.