Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
6 days ago
$75K - $113K *
Empower patients by coordinating personalized hospice care, assessing needs, and collaborating with a dedicated care team to enhance quality of life and ensure compassionate support throughout the car...
1 week ago
Senior Clinical Research Associate, Medical Device
$110K - $138K *
Lead the charge in clinical trial monitoring, ensuring adherence to protocols and regulatory standards while fostering collaboration and quality improvement across teams and sites...
Reposted 1 week ago
Sr Advisor Recruiting Specialist
$100K - $120K *
Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...
2 weeks ago
Group Hospital Services Administrator
$112K - $163K *
Empower your leadership skills to enhance patient care across multiple hemodialysis facilities. Oversee operations, manage teams, and ensure quality standards while driving financial performance and t...
5 days ago
Project Manager II, dermatology and rheumatology CRO,USA
$95K - $115K *
Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...
6 days ago
CGI OpenGrid Implementation Analyst, Sr. Associate
$77K - $202K *
Lead the charge in implementing CGI OpenGrid solutions, analyzing client needs, and guiding junior team members while enhancing operational efficiency through innovative business software solutions...
4 days ago
$110K - $130K *
Advance your career by leading consultancy projects, managing workstreams, and enhancing client relationships. Contribute to business growth through strategic development and deliver impactful client...
Reposted yesterday
$131K - $237K *
Empower mission success by transforming complex data into actionable insights. Lead the design and operationalization of advanced data science capabilities, collaborating with cross-functional teams t...
2 weeks ago
Inpatient Neurosurgery - Physician Assistant Specialty Care III (Dual Posted with Job ID: 61343)
$108K - $177K *
Elevate patient care by providing expert support in a multidisciplinary neurosurgery practice. Collaborate with surgeons to diagnose, treat, and assist in procedures for adult patients, while particip...
3 weeks ago
$90K - $108K *
Analyze and optimize enterprise data workflows, ensuring stakeholders access accurate data. Collaborate on analytics development, support data transformation in Microsoft Fabric, and enhance reporting...
1 week ago
Executive Vice President Inpatient Services
$210K - $250K *
Elevate healthcare delivery by leading inpatient services, driving strategic growth, and ensuring clinical excellence. Collaborate with senior leadership to optimize performance and foster a culture o...
1 week ago
$69K - $101K *
Grow your career with a dynamic team providing holistic clinical care management services. Collaborate with diverse populations to enhance health outcomes through assessment, care planning, and coordi...
1 week ago
Physician/Deputy ACOS Primary Care Service
$180K - $220K *
Join a team that's dedicated to enhancing primary care for Veterans. Lead clinical initiatives, supervise staff, and engage in quality improvement projects while providing comprehensive patient care i...
2 weeks ago
Manager of Clinical Engagement
$115K - $130K *
Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...
Reposted yesterday
AEC Healthcare Project Manager
$110K - $130K *
Shape the future of healthcare by leading complex architectural and facility projects, ensuring optimal client service and regulatory compliance throughout all project phases while guiding multidiscip...
Reposted 1 week ago
Research Data Analysis Supervisor 2 - Remote - 141980
$111K - $211K *
Advance your career by leading impactful research in public health and family planning. Drive data analysis and quality assurance efforts across low- and middle-income countries, collaborating with di...
6 days ago
Actuarial AI Transformation Consulting Director
$155K - $220K *
Drive innovation in actuarial functions by leveraging AI and advanced analytics. Lead high-impact initiatives that transform insights into actionable business strategies, enhancing decision-making and...
3 weeks ago
Senior Director, Clinical Risk & Insights
$204K - $276K *
Unlock potential by leading Clinical Risk & Insights, driving systemic investigations and RCA methodologies to enhance clinical execution and decision-making across portfolios, ensuring sustained impr...
Yesterday
Manager Pricing - Retail, Technology, Healthcare
$105K - $115K *
Lead financial pricing strategies and support sales operations through analytical insights, forecasting, and continuous improvement initiatives. Collaborate with cross-functional teams to optimize mar...
2 weeks ago
AVP of Underwriting - Great American Employer Health Solutions
$150K - $180K *
Lead the charge in underwriting operations and strategy, developing a high-performing team while enhancing practices to support profitable growth in the medical stop loss and level-funded business. Bu...
Yesterday
Strategic Advisor IV (Remote/Hybrid)
$119K - $144K *
Shape the future of organizational consulting by leading complex client engagements, transforming data into actionable insights, and influencing C-suite decisions while fostering team development and...
4 days ago
Facilities Management Director
$100K - $120K *
Shape the future of healthcare facilities by ensuring compliance, safety, and comfort in rehabilitation environments. Lead maintenance programs and foster an inclusive culture while enhancing patient...
3 weeks ago
$72K - $104K *
Lead the charge in enhancing customer care quality through effective monitoring, collaboration, and continuous improvement initiatives. Drive actionable insights and training to elevate service standa...
2 days ago
Enterprise Account Executive, Home-Based Care Sales
$128K - $150K *
Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...
Reposted 1 month ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.