Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$175K - $200K *

Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$142K - $186K *

Deliver trusted, governed product data by designing scalable ELT pipelines and analytics models. Collaborate across teams to ensure data quality and compliance, empowering stakeholders with self-servi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$107K - $199K *

Unlock potential by leading financial modeling and risk assessment for value-based care arrangements. Collaborate with teams to analyze vendor performance and drive strategic insights, ensuring contra...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $147K *

Drive proactive analysis of the cyber threat landscape, translating insights into actionable strategies for information security. Collaborate with teams to enhance preparedness and countermeasures, le...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $90K *

Drive impactful analytics solutions by leading customer engagement workstreams, optimizing digital communications, and mentoring junior analysts. Leverage data to enhance government program performanc...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $158K *

Join a team that's dedicated to optimizing operations in a fast-paced environment. Support technical and functional stakeholders while ensuring seamless processing and troubleshooting across systems...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $231K *

Advance your career by leading healthcare analytics initiatives that transform data into impactful insights, drive performance, and enhance decision-making across departments while fostering innovatio...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $104K *

Champion financial performance analysis for specialty pharmacy, collaborating with cross-functional teams to enhance revenue integrity and profitability through actionable insights and strategic recom...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $170K *

Join us to lead healthcare data and cloud transformation initiatives, guiding organizations through modernization efforts. Leverage your expertise in cloud architecture and data analytics to drive str...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $90K *

Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$69K - $125K *

Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$72K - $120K *

Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $250K *

Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join a team that's dedicated to driving financial excellence through detailed analysis, reporting, and strategic recommendations. Collaborate with leadership to enhance financial performance and suppo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $125K *

Join a team that's dedicated to delivering accurate sales reporting and data maintenance. This role supports sales leaders and partners by managing reporting queues, ensuring data integrity, and enhan...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $131K *

Contribute to the development and administration of competitive compensation programs, ensuring alignment with organizational strategy. Lead projects and provide consultation to HR partners while main...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$141K - $234K *

Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$103K - $121K *

Champion project success by building pacing trackers and forecasting models, collaborating with Finance to enhance capacity planning and resource allocation, while providing leadership with real-time...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $128K *

Drive impactful actuarial analyses and modeling to enhance healthcare services, collaborating with teams to ensure accurate financial forecasting and decision support that shapes health program strate...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.