Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$73K - $125K *

Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $132K *

Drive organizational change by analyzing processes, engaging stakeholders, and implementing effective strategies. Collaborate with teams to enhance operational efficiency and ensure successful adoptio...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$140K - $160K *

Drive operational excellence and strategic growth in behavioral health services, ensuring patient-centered care and compliance. Collaborate with leadership to enhance quality, access, and financial pe...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $127K *

Empower finance teams by bridging systems and analysis, enhancing budgeting, forecasting, and reporting processes. Collaborate with stakeholders to translate needs into effective solutions, driving im...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$210K - $250K *

Elevate healthcare delivery by providing remote GI services to Veterans. Collaborate with facility leaders to establish clinics, manage patient panels, and ensure timely access to care while adhering...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$143K - $179K *

Analyze customer experiences to drive retention strategies and enhance satisfaction. Collaborate across teams to shape data-driven decisions, develop metrics, and prioritize analytics initiatives that...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $105K *

Lead the charge in enhancing quality assurance and performance oversight by analyzing requirements and deliverables, ensuring alignment with contractual standards, and driving process improvements for...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$116K - $155K *

Shape the future of HR technology by leading strategy, governance, and optimization of HRIS. Drive operational excellence, enhance user experience, and ensure compliance while managing a high-performi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$122K *

Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $140K *

Lead transformative healthcare initiatives by fostering client relationships, driving impactful research, and developing high-performance teams to achieve strategic goals and business growth...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$70K - $115K *

Empower your career by joining a dynamic team focused on healthcare compliance auditing. Utilize your analytical skills to drive impactful audits and contribute to client deliverables while receiving...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join a team that's dedicated to providing personalized primary care to seniors in their homes. As a Nurse Practitioner, you'll deliver comprehensive medical services, collaborate with healthcare teams...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $140K *

Reimagine client success by managing relationships and ensuring seamless communication across teams. Drive operational excellence and enhance client satisfaction through proactive updates, coordinatio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $110K *

Contribute to impactful education research by designing and conducting rigorous quantitative studies, synthesizing evidence, and translating findings into actionable insights for policy and practice...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Engage with senior stakeholders to enhance R&D efficiency in life sciences. Drive proposals, develop strategies, and ensure quality oversight while building networks to support business development an...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$193K - $256K *

Transform client success by leading a large team to enhance service delivery, drive strategic initiatives, and leverage technology for improved client outcomes across diverse segments in a dynamic env...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $136K *

Join a team that's redefining customer experience by translating complex business needs into actionable technical requirements, ensuring seamless integration across platforms and delivering innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$83K *

Drive quality improvement initiatives that enhance service delivery and client satisfaction. Oversee program standards, assess needs, and lead a dedicated team to ensure compliance and excellence in c...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate patient care by joining a dynamic Orthopedic Trauma team, providing critical support through consults, reductions, and traction. Collaborate with physicians and staff to enhance outcomes in a...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Join a team that's redefining data solutions by leading the Data Products & Engineering department, shaping cutting-edge data architectures and innovative client-facing analytics solutions that drive...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$88K - $105K *

Transform clinical trials by leading monitoring efforts, ensuring compliance with protocols and regulations while fostering collaboration and quality improvement across teams and sites...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Engage with leading U.S. healthcare providers to strengthen relationships, enhance performance, and drive revenue growth through proactive client management and consultative support in a dynamic team...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.