Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Regional Health Physicist - South Central US
$110K - $151K *
Champion operational excellence by ensuring radiation safety and EHS compliance across cyclotron manufacturing and PET nuclear pharmacy facilities in the South Central US, while collaborating with cro...
2 weeks ago
Bank Data Analyst II - CECL & Credit Risk
$80K - $95K *
Innovate within a dynamic team to enhance credit risk data analytics, ensuring data integrity and supporting strategic initiatives through advanced analysis and automation. Collaborate with stakeholde...
3 weeks ago
$155K - $258K *
Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...
1 week ago
Senior Technical Product Manager - Insurance Products & Benefits
$104K - $143K *
Lead the charge in developing and delivering innovative technology solutions for managing Medicare/Medicaid plans. Collaborate with cross-functional teams to drive product vision, strategy, and execut...
Reposted 1 week ago
ITS Epic Willow Inpatient Pharmacist Analyst II - Remote
$104K - $190K *
Shape the future of pharmacy IT by mentoring staff and enhancing application functionality. Collaborate on planning, development, and support while ensuring quality through effective testing and evalu...
2 days ago
Deputy Associate General Counsel for Program Review Division (CMS)
$150K - $180K *
Lead a dynamic legal team providing strategic counsel on Medicare, Medicaid, and healthcare policy initiatives. Drive high-quality legal advice, manage complex regulatory issues, and engage with senio...
Today
Pediatric Advanced Practice Provider - Hospitalist
$95K - $115K *
Join a team that's dedicated to delivering high-quality inpatient care for pediatric patients. Utilize advanced skills to assess, diagnose, and treat children in a collaborative environment, ensuring...
Today
$77K - $135K *
Grow your career with us by developing high-quality software solutions as part of a dynamic team. Collaborate on complex projects, enhance your skills, and contribute to innovative software developmen...
1 week ago
Sr Life Underwriting Business Systems Analyst
$85K - $100K *
Champion life underwriting transformation initiatives by analyzing requirements, facilitating project lifecycles, and collaborating with cross-functional teams to enhance operational excellence and im...
1 week ago
Account Executive - Government
$80K - $95K *
Grow your career by developing and maintaining key customer relationships, driving sales success, and collaborating with teams to exceed goals. Leverage your expertise in account management and sales...
3 weeks ago
Managing Engineer, Data Engineering
$120K - $193K *
Drive innovation in data engineering by leading teams to design and deliver scalable data solutions. Collaborate with cross-functional partners to enhance analytics and decision-making, ensuring high...
4 weeks ago
Senior Consultant - Clinical Operations
$89K - $148K *
Drive your career with impactful consulting in healthcare, enhancing operational efficiency and financial performance for provider organizations through data analysis and project management...
1 week ago
$80K - $95K *
Optimize coding education and compliance for healthcare providers. Lead a team to enhance clinical documentation, develop training plans, and ensure adherence to regulations, driving improvements in b...
2 weeks ago
Health Industry – Payer Utilization Management Consulting Manager
$87K - $253K *
Engage in leading client engagements and drive successful project delivery, fostering trust-based relationships and harnessing a high-performing team environment while developing tailored solutions fo...
Reposted yesterday
Senior Cybersecurity Analyst (Service Recovery)
$125K - $130K *
Join a dynamic team as a Senior Cybersecurity Analyst, focusing on IT service recovery and business continuity. Collaborate with federal staff to develop strategies that ensure operational resilience...
4 days ago
Pharmacy & Clinical Systems Engineer
$100K - $120K *
Pioneer seamless pharmacy integrations by managing e-prescribing workflows, ensuring compliance, and optimizing operations. Become the go-to expert for pharmacy software, enhancing patient medication...
Today
$110K - $130K *
Join a team that's dedicated to enhancing enterprise IAM governance. You'll oversee access reviews, ensure compliance, and collaborate with cross-functional teams to strengthen security controls and d...
6 days ago
$137K - $171K *
Engage healthcare providers as a scientific expert, delivering education and insights on oncology products. Collaborate with teams to support Medical Affairs initiatives while maintaining compliance a...
Yesterday
Clinical & Financial Performance Manager
$87K - $253K *
Lead the charge in aligning clinical performance with financial outcomes, optimizing cost of care and enhancing quality. Collaborate with cross-functional teams to drive improvements in care standards...
Reposted yesterday
Transitions of Care Advanced Practice Provider (NP or PA)
$120K - $150K *
Join a team that's dedicated to enhancing patient care through comprehensive post-discharge support. As an Advanced Practice Provider, you'll manage complex cases, collaborate with interdisciplinary t...
4 weeks ago
Analyst (Energy and Climate Modeling)
$80K - $100K *
Unlock insights through quantitative analysis and research, shaping energy policy scenarios while collaborating with stakeholders to enhance philanthropic grantmaking efforts and present findings thro...
Reposted 2 weeks ago
Sr Director, Analyst - Data Management and AI Readiness
$172K - $202K *
Lead the charge in delivering innovative insights and strategies for clients, leveraging in-depth market analysis and research expertise to address complex challenges and drive actionable results for...
Reposted 5 days ago
Payment Integrity Clinical Readmission Manager
$73K - $125K *
Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...
3 weeks ago
Program Analyst – Organizational Change Management (OCM)
$73K - $132K *
Drive organizational change by analyzing processes, engaging stakeholders, and implementing effective strategies. Collaborate with teams to enhance operational efficiency and ensure successful adoptio...
3 weeks ago
Administrative Director of BEHAVIORAL HEALTH SERVICE LINE
$140K - $160K *
Drive operational excellence and strategic growth in behavioral health services, ensuring patient-centered care and compliance. Collaborate with leadership to enhance quality, access, and financial pe...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.