Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$193K - $340K *

Lead analytics initiatives to empower strategic decisions in a fast-growing agent business. Drive insights, build foundational data systems, and foster a high-performing team to enhance user experienc...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$76K - $199K *

Elevate sales and customer relationships by engaging effectively with healthcare providers. Utilize analytical skills and digital tools to drive strategic business development and promote breakthrough...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $129K *

Unlock potential by providing advanced support for Momentum Financials, collaborating with stakeholders to resolve issues, and enhancing system functionality in a dynamic environment. Bring your analy...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Transform healthcare technology by owning core products, driving architectural decisions, and ensuring high-quality code. Collaborate across teams to deliver impactful solutions that enhance patient c...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Lead the charge in managing complex Life Sciences programs, ensuring alignment with customer commitments. Drive delivery across teams, proactively addressing risks and building a PMO as the business s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Unlock potential by leading product marketing initiatives that empower healthcare teams. Drive sales enablement, module marketing, and customer expansion, while shaping messaging and content that reso...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$61K - $113K *

Unlock potential by conducting comprehensive behavioral health assessments, providing evidence-based interventions, and collaborating with a multidisciplinary team to enhance patient care and treatmen...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $207K *

Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$170K - $200K *

Pioneer innovative solutions by leading client engagements with top firms. Drive discovery, connect needs to data insights, and collaborate across teams to deliver impactful results in a dynamic, remo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $190K *

Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $120K *

Elevate clinical trial success by providing expert oversight and guidance. Collaborate with cross-functional teams to ensure compliance, quality, and timely execution of monitoring activities while fo...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's transforming healthcare by driving enterprise sales and partnerships with leading health systems. Leverage your expertise to educate executives on innovative solutions that enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K *

Drive the future of project controls by providing expert EVM, cost, and schedule analysis for federal programs. Collaborate with cross-functional teams to enhance decision-making and ensure program co...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$130K - $135K *

Join a team that's dedicated to enhancing federal cybersecurity compliance through advanced risk management and governance. Leverage your expertise to conduct assessments, manage authorizations, and e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$94K - $164K *

Champion cost reporting processes by ensuring data accuracy, preparing detailed reports, and analyzing financial information. Collaborate across departments to enhance reporting systems and support st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in AI innovation within our Insurance portfolio, overseeing the full lifecycle of solutions from ideation to production. Shape strategy, manage multidisciplinary teams, and build new c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Elevate your career by leveraging your expertise in business analysis to enhance Momentum Financials and Acquisitions. Collaborate with stakeholders to drive process improvements and ensure effective...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$171K - $190K *

Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$84K - $126K *

Join a team that's driving growth in the cardiovascular ASC market by developing strategic partnerships and executing innovative market strategies across the U.S. Collaborate with diverse stakeholders...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$200K - $250K *

Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$250K - $300K *

Help us provide compassionate, patient-centered care to homebound seniors, managing chronic and acute conditions while collaborating with interdisciplinary teams to enhance health outcomes and ensure...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in optimizing business processes and technology solutions, serving as the primary liaison between stakeholders and technical teams to enhance operational efficiency and customer experi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Join a dynamic team as a data analyst, focusing on credit risk and loan portfolio analytics. Leverage data science methodologies to ensure data integrity and support management reporting while collabo...

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $132K *

Join a team that's dedicated to enhancing cybersecurity measures across cloud environments. Lead initiatives in data protection, compliance, and security awareness while mentoring peers and implementi...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.