Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Director, Observational Research, CPSO
$204K - $276K *
Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...
5 days ago
Senior Case Manager RN - Transplant RN (Remote)
$79K - $127K *
Optimize member health outcomes by managing complex care plans, coordinating services, and advocating for quality, cost-effective healthcare. Collaborate with healthcare teams to assess needs and moni...
Reposted 2 weeks ago
$153K - $210K *
Strategize and enhance data integrity across extensive systems, ensuring all operational data is accurate and reliable for key clinical and financial workflows while enabling self-serve analytics for...
Reposted 1 week ago
Senior Audit Remediation Analyst
$98K - $163K *
Support audit remediation initiatives by coordinating with stakeholders, analyzing findings, and developing strategies to enhance audit readiness and internal controls, ensuring effective communicatio...
6 days ago
Enterprise Risk Management Data Analytics Lead
$156K - $181K *
Elevate enterprise risk management by designing and executing data analytics solutions. Collaborate with stakeholders to enhance reporting processes and deliver insights that drive strategic decision...
2 days ago
$110K - $130K *
Empower value-based contracting initiatives by negotiating and operationalizing arrangements. Ensure effective communication with stakeholders while upholding organizational values and service standar...
4 weeks ago
$80K - $95K *
Lead the end-to-end recruiting process, enhancing strategies and partnerships across departments. Drive high-volume hiring with autonomy, ensuring a seamless candidate experience while collaborating c...
2 weeks ago
$110K - $130K *
Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...
Reposted 2 days ago
Nurse Practitioner or Physician Assistant - Oncology - Springfield, MO
$95K - $115K *
Champion quality patient care by collaborating with a dedicated team of physicians and advanced practitioners in a supportive environment focused on oncology services and patient outcomes...
Reposted 5 days ago
Senior Product Manager, Value-Based Care Platforms
$130K *
Drive innovation in healthcare technology by leading product management efforts, connecting cross-functional teams, and shaping the product roadmap to enhance value-based care solutions. Engage hands...
4 days ago
Cybersecurity Senior Incident Response Analyst - Remote based in the US
$103K - $140K *
Engage in advanced cybersecurity incident response, leading investigations and recovery efforts. Collaborate with cross-functional teams to enhance security posture and document findings, ensuring org...
4 weeks ago
$200K - $225K *
Transform healthcare data into actionable insights by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercia...
Today
Analytics Engineer, Semantic Layer
$80K - $95K *
Champion the creation of semantic models on our Snowflake platform, ensuring accuracy and clarity in financial reporting. Collaborate across teams to translate complex business logic into reliable dat...
2 weeks ago
$80K - $95K *
Shape the future of patient care by leveraging your nursing expertise and informatics. Optimize clinical information systems while collaborating with interdisciplinary teams to enhance the overall hea...
Reposted yesterday
Associate Director, Methods and Data Standards
$125K - $145K *
Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...
1 week ago
Insurance - Industry & Function AI Decision Science Manager
$87K - $293K *
Lead and manage end-to-end data science projects, leveraging AI and analytics to drive efficiency and growth. Collaborate with teams and stakeholders to deliver innovative solutions that align with st...
2 weeks ago
Senior Compliance Administrator - Auditing & Monitoring
$87K - $157K *
Shape the future of compliance by designing and implementing programs that ensure regulatory alignment, mitigate risks, and foster a culture of accountability across diverse business operations...
Reposted yesterday
$83K - $114K *
Join us to provide exceptional preventive dental care, educate patients, and enhance smiles. Collaborate with a dedicated team focused on patient comfort and continuous improvement in a supportive env...
1 week ago
Executive Director of Human Resources
$110K - $130K *
Transform the Human Resources landscape by leading strategic initiatives that enhance colleague engagement, optimize workforce planning, and ensure operational excellence in a healthcare setting, all...
4 days ago
Software Engineer - ML Ops (R37)
$140K - $270K *
Unlock your potential by managing ML systems at scale, ensuring uptime and observability. Collaborate on deploying and scaling models, while enhancing platform reliability through advanced engineering...
3 weeks ago
Senior Product Manager, Epic Optimization
$101K - $152K *
Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...
2 weeks ago
Senior Director, Data Architecture
$150K - $180K *
Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...
3 weeks ago
Senior Director, Partnerships Analytics
$193K - $340K *
Lead analytics initiatives to empower strategic decisions in a fast-growing agent business. Drive insights, build foundational data systems, and foster a high-performing team to enhance user experienc...
Reposted today
Cardiovascular Specialist, Health and Science Professional - Columbia, MO
$76K - $199K *
Elevate sales and customer relationships by engaging effectively with healthcare providers. Utilize analytical skills and digital tools to drive strategic business development and promote breakthrough...
2 weeks ago
$63K - $129K *
Unlock potential by providing advanced support for Momentum Financials, collaborating with stakeholders to resolve issues, and enhancing system functionality in a dynamic environment. Bring your analy...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.